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  • 1
    Electronic Resource
    Electronic Resource
    First human hand transplantation (2000)
    Springer
    Transplant international 13 (2000), S. S521 
    Details
    ISSN: 1432-2277
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470000288
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  • 2
    Electronic Resource
    Electronic Resource
    Pathology of the pancreas after intraductal neoprene injection in dogs and diabetic patients treated by pancreatic transplantation (1983)
    Springer
    Diabetologia 25 (1983), S. 97-107 
    Details
    ISSN: 1432-0428
    Keywords: Pancreas ; transplantation ; injection of neoprene ; diabetes ; dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The injection of neoprene into the pancreatic ducts of dogs has been used to destroy exocrine function prior to pancreatic transplantation. The subsequent histological changes and the evolution of lesions over a period of 3–36 months are described. Animals were sacrified or biopsied at various intervals (3, 15 and 36 months) and the pancreases showed the disappearance of exocrine acini and changes of chronic pancreatitis. An immunoperoxidase procedure with insulin, glucagon, somatostatin and pancreatic polypeptide antisera was used to show the persistence of pancreatic endocrine cells. After the injections, sclerosis progressively increased and secondary lesions of the islets were seen, although functional islets persisted. This technique was then applied to pancreas transplantation in man. Eight transplants from seven diabetic patients were available for examination. In four cases, there were early technical failures, but four pancreatic transplants continued to function for 28–889 days until suppuration destroyed one of the grafts and the three other patients died. The persistence of endocrine cells in sclerotic tissue was observed in histological and immunopathological examinations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00250896
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  • 3
    Electronic Resource
    Electronic Resource
    Endocrine responses of type 1 (insulin-dependent) diabetic patients following successful pancreas transplantation (1983)
    Springer
    Diabetologia 24 (1983), S. 244-248 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; pancreas transplantation ; pancreas ; insulin ; glucagon ; growth hormone ; kidney transplantation ; somatostatin (cyclic)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of the present study was to evaluate the insulin and glucagon responses to various stimuli in patients following pancreatic transplantation. Four Type 1 (insulin-dependent) diabetic patients with end-stage renal failure who had received a cadaveric segmental, neoprene-injected, pancreas transplant, in association with kidney transplantation, were investigated. Free-insulin, pancreatic glucagon, and growth hormone concentrations were measured after both oral and intravenous glucose tolerance tests, and following tolbutamide, arginine and arginine plus somatostatin infusions. Tests were performed 1 month (three cases) and 30 months (one case) after surgery, when no insulin administration was required. Four non-diabetic kidney grafted patients, matched for duration of graft survival and immunosuppressive treatment (steroids, azathioprine and anti-lymphocyte-globulins), served as control subjects. Impaired glucose tolerance was present in all diabetic and control patients. This was possibly related to immunosuppressive treatment. In comparison with control subjects, insulin release was normal in response to arginine and tolbutamide but was reduced in response to oral and intravenous glucose, while glucagon and growth hormone release were similar in both groups. Somatostatin was less effective in diabetic patients than in control subjects in suppressing insulin and glucagon release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282707
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  • 4
    Electronic Resource
    Electronic Resource
    Pancreas transplantation in Lyon: overall results (1991)
    Springer
    Diabetologia 34 (1991), S. S8 
    Details
    ISSN: 1432-0428
    Keywords: Transplantation ; Pancreas ; Duct obstruction ; Enteric drainage ; Bladder drainage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 182 pancreatic transplantations were performed between 1976 and 1990. Survival of the grafts was 45% at 5 years. Major causes of graft loss have been rejection and venous thrombosis. Death occured in 24 patients and was usually related to vascular complications. The techniques of duodenopancreatic transplantation with enteric drainage, bladder drainage and the technique of segmental duct obstructed grafts were compared. A higher rate of surgical complications was observed with enteric drainage, whereas it is unclear from the data whether segmental grafts or duodenopancreatic grafts drained into the bladder lead to different results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587608
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  • 5
    Electronic Resource
    Electronic Resource
    Thirty months' experience with cyclosporin in human pancreatic transplantation (1984)
    Springer
    Diabetologia 27 (1984), S. 154-156 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; cyclosporin ; pancreatic transplantation ; renal transplantation ; immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between September 1978 and December 1983, 33 simultaneous kidney plus pancreatic transplantations were performed in Type 1 (insulin-dependent) diabetic patients with uraemia at the Herriot Hospital, Lyon. In eight patients grafted before June 1981, immunosuppressive treatment consisted of azathioprine, steroids and a temporary course with anti-lymphocyte globulins (protocol A). Since June 1981, the immunosuppressive treatment has consisted of cyclosporin administered according to two protocols: from the day of transplantation with temporary anti-lymphocyte globulins with or without steroids (protocol B, seven patients), or after an initial course with protocol A, with or without steroids (protocol C, 18 patients). Only slight differences in patient and pancreatic graft survival between the three protocols were observed at 3, 6 and 12 months, while an improved survival rate for both patients and pancreatic grafts was observed in protocols B and C at 2 years. Moreover the incidence of pancreatic rejection as a cause of loss of pancreatic function seemed to be reduced under protocols B and C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275676
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  • 6
    Electronic Resource
    Electronic Resource
    Metabolic control after kidney and pancreas transplantation: whole series results and effects of segmental duct obstruction versus whole pancreas with bladder diversion technique (1991)
    Springer
    Diabetologia 34 (1991), S. S51 
    Details
    ISSN: 1432-0428
    Keywords: Pancreas transplantation ; Bladder diversion ; Oral Glucose Tolerance Test ; Type 1 (insulin-dependent) diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From October 1976 to December 1990 181 pancreatic transplants were performed in our centre on 171 Type 1 (insulin-dependent) diabetic patients. Oral glucose tolerance test evaluated 1 year after surgery in 31 subjects showed an impaired glucose tolerance at 120 min (blood glucose 9.5±0.6 mmol/l). Similar results were obtained in seven patients 3 years after transplantation (blood glucose at 120 min 8.3±1.08 mmol/l). 24h metabolic profiles performed at the same intervals showed near normal blood glucose levels and good insulin release. Preliminary data concerning a randomized, comparative study between whole pancreas with bladder diversion and segmental pancreas transplantation, showed better metabolic control in the patients who received the whole pancreas, probably due to the greater islet mass grafted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587619
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  • 7
    Electronic Resource
    Electronic Resource
    Ophthalmological follow-up of Type 1 (insulin-dependent) diabetic patients after kidney and pancreas transplantation (1991)
    Springer
    Diabetologia 34 (1991), S. S89 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic retinopathy ; Pancreas transplantation ; Insulin-dependent diabetes mellitus ; Type 1 diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the effect of successful kidney and pancreas transplantation on visual function and diabetic retinopathy in 18 patients with long-term Type 1 (insulin-dependent) diabetes mellitus (17 to 38 years) and with advanced proliferative retinopathy. The average age of the patients was 42 years. Prior to transplantation, 5 eyes were in end-stage ophthalmic complication due to neovascular glaucoma. An ophthalmological follow-up was performed between 1–6 years post-surgery. Analysis of the results showed that the diabetic retinopathy had stabilized after transplantation in 12 cases (66 %) with a supplementary photocoagulation in the majority of cases. The proliferation continued in 4 patients (22 %) leading to blindness in 2 patients and recurrence of vitreous haemorrhages despite the photocoagulation in the other 2 cases. An improvement was observed on fluorescein angiography in a patient with pre-papillar glial proliferation without photocoagulation. Ten patients were reported to have a cataract and were operated on in two cases before transplantation; in one patient, the cataract increased following transplantation. In conclusion, the kidney and pancreas transplantation was not effective in our patients in reversing the clinical and angiographic signs of diabetic retinopathy. Moreover, a worsening of the lesions was observed in some cases; this was probably due to the irreversible microangiopathic lesions due to advanced evolution of diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587628
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  • 8
    Electronic Resource
    Electronic Resource
    Sequential electrodiagnostic evaluation of diabetic neuropathy after combined pancreatic and renal transplantation (1991)
    Springer
    Diabetologia 34 (1991), S. S100 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic polyneuropathy ; Pancreas and kidney transplantation ; Electrophysiological survey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To asses the long-term evolution of diabetic polyneuropathy after a combined kidney-pancreas transplant, an electrophysiological study was performed in 20 diabetic patients before transplant, and 1 (n=18), 2 (n=16), 3 (n=10) and 4 years (n=5) at a later date. Motor and sensory scores were calculated for conduction velocity and amplitude to determine the physiopathological process. During evolution the scores were not found to be decreasing. Motor and sensory velocity scores were significantly improved (p〈0.05) 1 and 2 years after the graft, when score values tended to stabilize. Motor and sensory amplitude scores, which are more sensitive for axonal loss assessment were slightly but not significantly improved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587631
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of the surgical technique on long-term outcome of pancreas transplantation (1998)
    Springer
    Transplant international 11 (1998), S. 295-300 
    Details
    ISSN: 1432-2277
    Keywords: Key words Pancreas transplantation ; diversion ; Enteric diversion ; pancreas transplantation ; Bladder diversion ; pancreas transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To date there is no general consensus as to the best surgical technique for pancreas transplantation. Patients with a pancreas transplant functioning for 3 years or more were retrospectively investigated to compare three surgical techniques: segmental graft with duct obstruction (DO), whole graft with bladder drainage (BD), and whole graft with enteric drainage (ED). Several parameters were studied: patient and graft survival, rejection, long-term surgical and medical complications, and endocrine function. The best results in terms of graft survival and quality of metabolic control were obtained in the group that underwent whole graft transplantation with ED. At 3 years, overall pancreas graft survival was 65 % for ED, 60 % for BD, and 47 % for DO. This surgical method has become the preferred technique in our unit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050145
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  • 10
    Electronic Resource
    Electronic Resource
    Endoscopic treatment of vesicoureteral reflux prior to renal transplantation (1992)
    Springer
    Transplant international 5 (1992), S. 231-233 
    Details
    ISSN: 1432-2277
    Keywords: Reflux, native kidney ; Kidney transplantation, reflux, native kidney ; Endoscopic treatment, ureter reflux
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endoscopic subureteral injection of Teflon was done in 34 potential renal transplant recipients to correct vesicoureteral reflux. Follow-up ranged from 6 to 24 months. After one injection reflux was corrected in 53.7% of the patients; this increased to 64.8% after a second injection. The procedure is simple, effective, without major morbidity, and avoids the risk of nephroureterectomy. However, efforts must be made to find an ideal substance with a higher biocompatibility and without risk of migration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336076
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