ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Controlled release silica sol-gels are room temperature processed, porous, resorbable, andbiocompatible materials. Many molecules including drugs, proteins, and growth factors can bereleased from sol-gels, and the quantity and duration of the release can vary widely. Processingparameters render these release properties exquisitely versatile [1]. The synthesis of controlledrelease sol-gels involves several steps: an acid-catalyzed hydrolysis to form a sol with the moleculesincluded, followed by casting, aging, and drying. Additional steps such as grinding and sieving arerequired to produce sol-gel granules of a desirable size. In this study, we focus on the synthesis ofcontrolled release sol-gel microspheres by using a novel process, which involves only two steps:solformation followed by emulsification. Sol-gel microspheres containing either vancomycin(antibiotic) or bupivacaine (analgesic) were successfully synthesized via this synthesis route. Bothdrugs showed controlled, load-dependent and time-dependent release from the microspheres. The invitro release properties of sol-gel microspheres were different from those of sol-gel granulesproduced by grinding and sieving. In comparison to a fast, short-term release from the granules, therelease from the microspheres was slower and of longer duration. In addition, the degradation rate ofmicrospheres was significantly slower than that of the granules. These data enable the use of sol-gelpowders for controlled long-term release
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1025.pdf
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