ISSN:
1662-8985
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) was used to make composite scaffoldsfor bone tissue engineering in our previous studies. To control the degradation rate and process ofcomposite scaffolds, PHBV was blended with poly(L-lactic acid) (PLLA), which has a much higherdegradation rate than PHBV, and PHBV/PLLA blends were used as polymer matrices for compositescaffolds. Composite scaffolds based on these blends and containing nano-sized hydroxyapatite(nHA) were fabricated using an emulsion freezing / freeze-drying technique. Non-porous films ofPHBV/PLLA blends were prepared using the solvent casting method. In vitro degradation tests ofnon-porous PHBV/PLLA blends and porous composite scaffolds were conducted by immersingsamples in phosphate buffered saline (PBS) for various periods of time. It was found that thecomposition of polymer blends affected water uptake of films and scaffolds. For PHBV/PLLA-basedscaffolds, the incorporated nHA particles also significantly increased water uptake within the initialimmersion time. Both PHBV/PLLA blends and composite scaffolds underwent rapid weight losseswithin the first few weeks. The degradation of composite scaffolds arose from the dissolution of nHAparticles and degradation of the PLLA component of polymer blends. Composite scaffolds exhibitedenhanced adsorption of bovine serum albumin (BSA), a model protein, in the current study
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.47-50.1399.pdf
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