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  • 1
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 1075 (1991), S. 191-194 
    ISSN: 0304-4165
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Marine geophysical researches 18 (1996), S. 459-486 
    ISSN: 1573-0581
    Keywords: Acoustics ; backscattering ; sonar image ; multibeam echo sounder ; sedimentology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Since early 1991, the EM12 dual multibeam echo sounder mounted on R/V L'Atalante has been mainly used for regional mapping and more particularly for EEZ exploration. The acoustic imagery data, which is collected at the same time as the multibeam soundings, and positioned with the same accuracy, illustrates the variability of the acoustic interface. The working principles of the multibeam echo souder are at rirst presented. The backscattering phenomena are then considered, where the echo structure is interpreted in terms of insonified area, propagation loss and backscattering strength; the latter, especially important for the seafloor acoustical characterization, is described as contributions from the interface roughness and the volume inhomogeneities. Problems associated with the seafloor type interpretation from the backscattered level data are briefly evoked. Then, the various operations associated with ‘mosaic’ computations are presented, describing the transition from the original time signals to the final image usable by geologists. Three examples, selected from a large set of data collected by IFREMER for SOPAC (SOPACMAPS Project) and the Territory of New Caledonia (ZoNéCo Project), both in late 1993, show that there are well differentiated acoustic reflectivity levels. After a description of their regional geological environment, the three examples are presented with the main results. These reflectivities, not yet calibrated in terms of field truth, are tentatively related to the previous existing data on the nature of the bottom and to the basic rules of marine sedimentology.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-6822
    Keywords: animal ; kidney tubules ; renal pharmacotoxicology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Among the cellular models used in in vitro renal pharmacotoxicology, isolated kidney tubules, used as suspensions mainly of proximal tubules, offer important advantages. They can be prepared in large amounts under nonsterile conditions within 1–2 h; thus, it is possible to employ a great number of experimental conditions simultaneously and to obtain rapidly many experimental results. Kidney tubules can be prepared from the kidney of many animal species and also from the human kidney; given the very limited availability of healthy human renal tissue, it is therefore possible to choose the most appropriate species for the study of a particular problem encountered in man. Kidney tubules can be used for screening and prevention of nephrotoxic effects and to identify their mechanisms as well as to study the renal metabolism of xenobiotics. When compared with cultured renal cell, a major advantage of kidney tubules is that they remain differentiated. The main limitations of the use of kidney tubules in pharmacotoxicology are (1) the necessity to prepare them as soon as the renal tissue sample is obtained; (2) their limited viability, which is restricted to 2–3 h; (3) the inability to expose them chronically to a potential nephrotoxic drug; (4) the inability to study transepithelial transport; and (5) the uncertainty in the extrapolation to man of the results obtained using animal kidney tubules. These advantages and limitations of the use of human and animal kidney tubules in pharmacotoxicology are illustrated mainly by the results of experiments performed with valproate, an antiepileptic and moderately hyperammonemic agent. The fact that kidney tubules, unlike cultured renal cells, retain key metabolic properties is also shown to be of the utmost importance in detecting certain nephrotoxic effects.
    Type of Medium: Electronic Resource
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