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  • 1
    Electronic Resource
    Electronic Resource
    Biochemical and Autoradiographical Determination of Protein Synthesis in Experimental Brain Tumors of Rats (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 59 (1992), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The rate of leucine incorporation into brain proteins was studied in rats with experimental brain tumors produced by intracerebral transplantation of the glioma clone F98. Incorporation was measured with [14C]leucine using a controlled infusion technique for maintaining constant specific activity of [14C]leucine in plasma, followed by quantitative autoradiography and biochemical tissue analysis. After 45 min the specific activity of free [14C]leucine in plasma was 2.5–3 times higher than in brain and brain tumor, indicating that the precursor pool for protein synthesis was fueled both by exogenous (plasma-derived) and endogenous (proteolysis-derived) amino acids. Endogenous recycling of amino acids amounted to 73% of total free leucine pool in brain tumors and to 60–70% in normal brain. Taking endogenous amino acid recycling into account, leucine incorporation was 78.7 ± 16.0 nmol/g of tissue/min in brain tumor, and 17.2 ± 4.2 and 9.7 ± 3.3 nmol/g/min in normal frontal cortex and striatum, respectively. Leucine incorporation within tumor tissue was markedly heterogeneous, depending on the local pattern of tumor proliferation and necrosis. Our results demonstrate that quantitative measurement of leucine incorporation into brain proteins requires estimation of recycling of amino acids derived from proteolysis and, in consequence, biochemical determination of the free amino acid precursor pool in tissue samples. With the present approach such measurements are possible and provide the quantitative basis for the evaluation of therapeutic interventions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1992.tb08870.x
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  • 2
    Electronic Resource
    Electronic Resource
    Supratentorial ependymomas in childhood: Clinicopathological findings and prognosis (1991)
    Springer
    Acta neurochirurgica 111 (1991), S. 96-102 
    Details
    ISSN: 0942-0940
    Keywords: Ependymoma ; childhood tumour ; hemispheric tumour ; ventricular tumour ; radiation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Out of 29 supratentorial ependymomas in children under 10 years of age, operated on between 1951 and 1989, 18 were situated in the hemispheres and 11 in the midline. 15 of the 18 hemispheric tumours, but only 4 of the 11 intra- or paraventricular ependymomas allowed complete removal. The operative mortality within the observation period of nearly 40 years was 27% for tumours in the midline and 11% for those in the hemispheres. The grade of malignancy rose with increasing distance from the ventricular level. 5-year survival without recurrence was 75% in grade 2 and 31% in grade 3 ependymomas. The total rate of recurrence was 58%. New tumour growth can be delayed by postoperative irradiation, at least in grade 2 ependymomas. It can be prevented, if at all, only by total resection of the primary tumour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400495
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  • 3
    Electronic Resource
    Electronic Resource
    Ganglioside Profiles in Human Gliomas: Quantification by Microbore High Performance Liquid Chromatography and Correlation to Histomorphology and Grading (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 1339-1345 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Gangliosides; microbore HPLC; astrocytoma; glioma.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ The composition and the content of gangliosides changes during physiological growth and differentiation as well as in neoplastic cell transformation. In order to determine if ganglioside profiles correlate with brain tumour malignancy, the ganglioside distribution was determined in 31 gliomas of astrocytic origin and in non-tumour tissue by a recently developed microbore high performance liquid chromatography (HPLC) method. Glioma malignancy was graded according to the grading system proposed by the World Health Organization (WHO) in 1993. In general, an increase of GD3 and a decrease of normal brain gangliosides correlated with a higher grade of malignancy. Pilocytic astrocytomas Grade I had a distinctive ganglioside profile, histologically as well as biochemically. Although they are low-grade gliomas, the pilocytic astrocytomas exhibited a GD3 content comparable to anaplastic gliomas and could only be biochemically distinguished from other tumour grades by relatively high type “b” ganglioside levels. Thus, ganglioside composition not only reflects anaplasia but can also be used to indicate biological characteristics of tumours of different histogenetic origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050439
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  • 4
    Electronic Resource
    Electronic Resource
    Lesions of the corpus callosum in hydrocephalic patients with ventricular drainage — a CT-study (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 174-178 
    Details
    ISSN: 0942-0940
    Keywords: Corpus callosum ; ventricular drainage ; CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients with ventricular drainage may develop lesions of the corpus callosum. In order to study frequency, pathogenesis and clinical relevance of callosal lesions, 301 routine CT investigations of 79 patients with ventricular drainage were reviewed. Hypodense lesions in the anterior part of the corpus callosum were observed in 7 patients with longstanding hydrocephalus of variable origin, in 2 cases the corpus callosum was slightly swollen. All 7 patients showed signs of forced ventricular drainage. The callosal alterations were clinically inapparent and potentially reversible. Knowledge of these lesions is important to avoid misinterpretation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411357
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  • 5
    Electronic Resource
    Electronic Resource
    Histological Study of Lumbar Intervertebral Disc Herniation in Adolescents (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 1107-1110 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Disc herniation; lumbar; adolescence; histology.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ Herniated intervertebral discs are rare in children and adolescents constituting approximately 1–5% of all patients undergoing surgery for lumbar and lumbosacral intervertebral disc herniation. Preceding traumata and congenital anomalities have been reported as important factors for the pathogenesis of intervertebral disc prolapses in young patients. The present histological study is based upon 15 patients with lumbar disc herniation within an age range from 14 to 19 years. Only in one case, was adequate trauma reported. All patients exhibited degenerative changes of the disc, similiar to those observed in adults. These changes were marked in 11 patients (73%).  Thus, as known from adults, also in isolated traumatic disc herniation of adolescence, pre-existing degeneration of the disc has to be considered. If such changes are present, trauma has the significance of only transitory deterioration of the previous disc degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010070037
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  • 6
    Electronic Resource
    Electronic Resource
    Multiple injuries: Coma and thoracic injury (1989)
    Springer
    Neurosurgical review 12 (1989), S. 37-41 
    Details
    ISSN: 1437-2320
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01790621
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  • 7
    Electronic Resource
    Electronic Resource
    Lymphocytic adenohypophysitis mimicking a pituitary macroadenoma (2000)
    Springer
    Neurosurgical review 23 (2000), S. 112-116 
    Details
    ISSN: 1437-2320
    Keywords: Key words Lymphocytic adenohypophysitis ; Pituitary adenoma ; Pituitary surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A 24-year-old woman developed headache and rapidly progressive visual disturbances during the last trimester of her first pregnancy. Magnetic resonance tomography (MRI) of the brain documented an intra- and suprasellar mass lesion. For preservation of vision, transsphenoidal microsurgical decompression was performed. Immediately postoperatively, visual acuity improved and hemianopia resolved. Histological examination yielded the diagnosis of primary lymphocytic adenohypophysitis. This is a rare inflammatory pituitary disease. There are no typical clinical, laboratory, or radiological findings that allow precise preoperative diagnosis. Even though this autoimmune disorder is principally steroid-responsive, an improvement of visual disturbances under steroid therapy cannot be predicted. Therefore, surgery is justified not only to establish the diagnosis, but also to restore vision by decompression of the optic nerves and the chiasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101430050011
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