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  • 1
    Electronic Resource
    Electronic Resource
    Acute pulmonary toxicity of a commercial fluorocarbon-lipid aerosol (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 1 (1977), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The death of an adolescent after deliberate inhalation of the domestic fluorocarbon-li9pid spray, PAM, triggered an investigation of the effects of this product on mammalian lung. Some of its constituents are known to destroy the lung-surfactant system, but death from its inhalation by earlier victims was usually attrubuted to the fluorocarbon's cardiac arrhythmogenic properties. In the present study, we applied methods and experimentl models not previously used to study the effects of this aerosol material on the lung surgactant. We found morphological and functiohal acute disintegration of normal alveolar surfactant, leading to extensive alveolar collapse, with sustained and elevated surface tensions in vitro. This could result in fatal hypoxaemia at inspired concentrations of fluorocarbons insufficient to cause cardiac arrhythmias, and may explain at least partly the large number of deaths associated with inhalation of such products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1977.tb01660.x
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  • 2
    Electronic Resource
    Electronic Resource
    Numbers of nuclei in different tissue compartments of fetal ventricular myocardium from 16 to 35 weeks of gestation (1998)
    Springer
    Virchows Archiv 433 (1998), S. 167-172 
    Details
    ISSN: 1432-2307
    Keywords: Key words Ventricles ; Myocardium ; Compartments ; Nuclei ; Number
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The aim of this study was to examine mechanisms of growth in different tissue compartments of the ventricular myocardium of prenatal human hearts. To this end, stereological methods were applied in order to estimate tissue volumes and total numbers of myocyte, connective tissue and endothelial nuclei in hearts collected after death at between 16 and 35 weeks of gestation. Volumes of tissue compartments were obtained after multiplying volume densities (estimated by test-point counting) by ventricular volumes (estimated from ventricular mass and tissue density). Absolute numbers of nuclei were calculated in similar fashion from corresponding nuclear packing densities (estimated using physical disectors). The volumes of all three tissue compartments increased linearly over the period of gestation examined, and in each case, the increase in tissue volume appeared to be due entirely to proliferation. Numbers of all three types of nuclei increased linearly whilst tissue volumes per nucleus remained constant. The net rate of production of myocyte nuclei was 35×107 per week (2.1 million nuclei per hour). The net rate of production of connective tissue nuclei was 12×107 per week (0.7 million nuclei per hour) and that for endothelial cell nuclei was 5.1×107 per week (0.3 million nuclei per hour). Predictions are made about the postnatal ages at which adult ratios of different nuclear types might be attained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050232
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    Paper (German National Licenses)
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