ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Enantioseparation
;
Chiralcel OD
;
γ-Lactams
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A high-performance liquid chromatographic method is reported for the resolution of the enantiomers of a series of fused γ-lactams (2,7-diaza-3-oxo[3.3.0]octan-6-ones) with probable anti-HIV and anticancer activity. Resolution was achieved on a Chiralcel® OD column, cellulose tris-(3,5-dimethylphenyl carbamate) adsorbed on macroporous silica gel; mixtures ofn-hexane and isopropyl alcohol in different proportions were used as the mobile phase. The analysis was studied at different temperatures.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02271012
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