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  • 1
    Electronic Resource
    Electronic Resource
    Neutrophil gelatinase levels in plasma and synovial fluid of patients with rheumatic diseases (1995)
    Springer
    Rheumatology international 15 (1995), S. 9-14 
    Details
    ISSN: 1437-160X
    Keywords: Neutrophil gelatinase ; Rheumatic diseases ; Vasculitis ; ELISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To examine the clinical significance of neutrophil gelatinase in rheumatic diseases, plasma and synovial fluid (SF) gelatinase levels were determined in 62 patients with rheumatoid arthritis (RA), 12 patients with ankylosing spondylitis (AS), 18 patients with osteoarthritis (OA) and 17 healthy controls. The gelatinase level was measured by enzyme-linked immunoassay (ELISA). The assay had a sensitivity of 1 ng/ml and a working range of 5–25 ng/ml. Gelatinase levels were significantly higher in the plasma of patients with RA and of patients with RA complicated by amyloidsis or vasculitis as compared to those of healthy controls. Moreover, the mean value of gelatinase in the plasma of patients with RA complicated by vasculitis was found to be significantly higher than that of RA patients without vasculitis. A significant increase in gelatinase concentration was also observed in the plasma of AS patients but not in the plasma of patients with OA. The concentration of gelatinase in the RA SF samples was much higher (18-fold) than the level of the enzyme in the plasma of RA patients. There was also a higher concentration of gelatinase (fourfold) in OA SF compared with OA plasma. The results suggested that circulating gelatinase may reflect some degree of neutrophil activation in patients with inflammatory arthritis, especially in those with RA complicated by vasculitis. However, the results did not allow a differentiation between chronic and acute inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286763
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Nabumetone Induces Less Gastrointestinal Mucosal Changes Than Diclofenac Retard (1999)
    Springer
    Clinical rheumatology 18 (1999), S. 273-278 
    Details
    ISSN: 1434-9949
    Keywords: Key words:Diclofenac – Efficacy – Endoscopy – Nabumetone – Osteoarthritis – Safety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The aim of the study was to compare the efficacy and the effects on the mucosa of the gastrointestinal tract (GIT) of nabumetone and diclofenac retard in patients with osteoarthritis (OA). An open, multicentre, randomised, comparative, endoscopy-blind parallel group study included 201 patients with nabumetone and 193 patients with diclofenac retard suffering from moderate to severe OA of the knee or hip joint. Twelve clinical efficacy variables were assessed and a portion of the population underwent gastroduodenoscopy. All patients exhibited significant improvement in pain severity and pain relief (p50.001 and p50.0001, respectively) but there were no differences between the groups for all the efficacy variables. Eleven per cent of patients on nabumetone and 19% on diclofenac experienced GIT side-effects. Sixty-nine patients with nabumetone and 61 with diclofenac underwent gastroduodenoscopy. The differences in the mucosal grade for the oesophagus, stomach and duodenum at baseline were not significant. In the oesophagus there were significantly less changes after treatment with nabumetone (p = 0.007) than with diclofenac; there were similar findings in the stomach (p50.001) but the difference in the duodenum was not significant. This study indicates that nabumetone and diclofenac retard have similar efficacy in the treatment of OA, but nabumetone has significantly fewer GIT side-effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670050101
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    HLA typing and seropositivity in finnish and in polish patients with rheumatoid arthritis and amyloidosis (1992)
    Springer
    Clinical rheumatology 11 (1992), S. 265-268 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Amyloidosis ; HLA Antigens ; Rheumatoid Factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We determined HLA-A,-B,-C and-DR antigens in 83 patients with rheumatoid arthritis (RA) and reactive secondary amyloidosis (RSA), 60 in Finland and 23 in Poland, and compared the results with control RA patients and blood donors. There were no significant differences in the frequencies of HLA between the RA patients with and those without RSA in either Finland or Poland, and no significant differences between the Finnish and Polish patients with RSA. All the RSA patients from Finland and 70% of the RSA patients from Poland were seropositive. In the development of RSA, the prolonged period of inflammatory stimuli may play a more important role than genetic factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207970
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    Paper (German National Licenses)
    Fulltext
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