Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Concerning the role of endogenous copper in the acute inflammatory process (1979)
    Springer
    Inflammation research 9 (1979), S. 581-588 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The development of two models of acute inflammation (carrageenan-induced foot oedema and pleurisy) was studied in rats after 1 month of a 0.2 p.p.m. copper-deficient diet and after 5 months of a 0.6–0.8 p.p.m. copper-deficient diet. A ‘pro-inflammatory’ effect of copper deficiency was observed with the 0.2 p.p.m. diet, whilst no effect was evident following the 0.6–0.8 p.p.m. copper-deficient diet. These results are briefly commented upon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968131
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Indomethacin induced hepatic alterations in mono-oxygenase system and faecal clostridium perfringens enterotoxin in the rat (1990)
    Springer
    Inflammation research 31 (1990), S. 313-316 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The administration of indomethacin to rats, at the dose of 10 mg/kg once daily for three days, caused a loss of microsomal cytochrome P-450 and cytochrome b5 in the liver, and a fall in drug-metabolizing enzyme activities (i.e. aminopyrine N-demethylase, NADP cyt. c. reductase). Indomethacin also induced intestinal lesions and a significant increase in Clostridium perfringens enterotoxin levels in the feces at 24 hours after both the second and third day of treatment. The above findings suggest that the development of intestinal lesion and the accompanying release of Clostridium perfringens enterotoxin, as well as hepatic enzyme alterations in the rat, result from indomethacin administration. Some of the data in this paper were presented at the Meeting of British Pharmacological Society in Ireland, July 6th–8th, 1988.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997625
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Multisystem toxicity of indomethacin: Effects on kidney, liver and intestine in the rat (1987)
    Springer
    Inflammation research 22 (1987), S. 310-313 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Some studies on the relationships among toxic effects in rat liver, kidney and intestine have been carried out. Indomethacin caused a marked reduction in microsomal enzymes, such as cytochrome P450, cytochrome b5 and aminopyrine N-demethylase in the kidney and the liver, greater in the former and for a shorter time than in the latter. Indomethacin induced intestinal lesions and marked overgrowth of intestinal bacteria, mainly of aerobic bacteria in the first 24 hours after its administration and anaerobic bacteria such as Clostridii in the second day. These findings enable us to suggest that the drug induces multisystem lesions through different mechanisms involving either a direct effect on the tissue or other microbiological or pharmacological factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02009061
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Influence of glutathione administration on the disposition of free and total platinum in patients after administration of cisplatin (1992)
    Springer
    Cancer chemotherapy and pharmacology 29 (1992), S. 385-390 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kinetics of platinum (Pt) was studied in 12 patients suffering from non-small-cell lung cancer or pleural mesothelioma. Each subject received an infusion of cisplatin (CDDP, 80 mg/m2), and six patients were pretreated with glutathione (GSH, 2.5 g given i.v.) at 15 min prior to the cisplatin infusion. After a 3- to 4-week interval, all patients were given a second course of treatment on the same schedule. A biexponential model was fitted to plasma concentrations of total and ultrafilterable Pt. The excretion of Pt in urine was evaluated during the first 48 h after the CDDP infusion. Following the administration of CDDP alone or with GSH pretreatment, the pharmacokinetic parameters of Pt did not significantly differ between the treatments. Also, the unbound fraction determined at each sampling time did not vary significantly between the treatments. However, it is noteworthy that the mean values obtained for the terminal half0life, the volume of distribution, the renal clearance, the percentage of the dose excreted in the urine, and the mean residence time of total Pt were higher in patients who had been pretreated with GSH, suggesting that SGH might increase both the rate of Pt elimination and the extent of Pt distribution and, as a consequence of the latter, might prolong the residence time of Pt in the body. In addition, the unbound fraction of Pt from the 4th to the 48th h was higher following the first dose of CDDP+GSH than after treatment with CDDP alone. Because of the rather high variability in the values of the parameters obtained, further work is planned using a larger number of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686008
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Metabolic interaction between n-hexane and toluene in vivo and in vitro (1982)
    Springer
    International archives of occupational and environmental health 50 (1982), S. 351-358 
    Details
    ISSN: 1432-1246
    Keywords: Metabolic interference ; n-Hexane ; Toluene ; Urinary metabolites ; Microsomal biotransformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Metabolic interference between n-hexane and toluene was studied both in vivo and in vitro. In in vivo experiments the urinary excretion of n-hexane and toluene metabolites was tested in rats treated with the two solvents separately or in combination. The same experimental program was repeated in rats pretreated with phenobarbital (PB). The urinary excretion of n-hexane metabolites in rats treated with the two solvents showed a significantly decreased excretion of all n-hexane metabolites in comparison with those treated with n-hexane alone. In rats pretreated with PB the excretion of n-hexane metabolites was significantly higher compared with that of unpretreated rats; the combined administration of the two solvents showed in this case, too, that n-hexane metabolite excretion was less than that found in rats treated with n-hexane alone. The biotransformation of toluene to o-cresol and hippuric acid studied in the urine of rats treated with or without n-hexane and pretreated or not with PB did not show any difference. The in vitro metabolic interference was studied by measuring the disappearance of solvents from rat's incubated liver microsomes. The maximum velocity (Vmax) of n-hexane was 2.8 nmol/g/min when incubated alone, 1.9 and 0.9 nmol/g/min when incubated with 5 and 20 μM of toluene respectively. The Vmax of toluene was 14.9 nmol/g/min when incubated alone and 13.1 and 10.5 nmol/g/min when incubated with 10.4 and 20.9 μM of n-hexane respectively. The inhibition constant (Ki) of toluene on n-hexane biotransformation was 7.5 μM and that of n-hexane on toluene was 30 μM. The data show that a mutual non-competitive interference exists in vitro betweeen n-hexane and toluene. The interference of toluene on n-hexane biotransformation was detectable also in vivo experiments, while n-hexane did not modify the biotransformation of toluene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00377831
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...