ISSN:
1432-1041
Keywords:
ANF-(99–126)
;
autonomic nervous system
;
nitroprusside
;
healting volunteers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary To delineate a possible interaction of atrial natriuretic peptide ANF-(99–126) with autonomic nervous system function in humans, a spectrum of indices were assessed in 10 healthy young men during a 90 min iv administration of a) synthetic ANF-(99–126) 50 μg bolus followed by 0.025 μg·kg−1·min−1, b) the potent vasodilator sodium nitroprusside (SNP) 0.35 μg·kg−1·min−1, or c) vehicle 0.9% NaCl 40 ml and 20% albumin 5 ml, in random sequence. Plasma immunoreactive ANF (irANF) rose from 32 to 1700 pg·ml−1 during the ANF-(99–126) infusion and was stable during SNP or vehicle. Infusion of ANF-(99–126) and SNP, but not vehicle, decreased diastolic blood pressure (BP) on average by −9 and −7.5%, respectively; systolic BP was largely unchanged. Heart rate (HR, +15 and 12%) or plasma norepinephrine (NE) rose similarly during ANF-(99–126) and SNP infusions, and the systolic BP response to orthostasis was similar (−18 mm Hg). The following autonomic indices did not differ significantly after the 3 infusions: responses of HR and NE to orthrostasis; reflex bradycardic response to phenylephrine (PE)-induced rise in systolic BP (+20 mm Hg); responses of BP to hyperventilation, PE, or 3 min of sustained handgrip; and beat-to-beat variation (R-R interval) during deep breathing. The immediate orthostatic HR response (30/15 R-R interval ratio) fell similarly during infusion of ANF-(99–126) or nitroprusside. The findings indicate that in healthy men the function of the autonomic nervous system is not notably impaired by high circulating ANF levels. ANF-(99–126) infused in moderate dosage seems to lower BP largely by non-autonomic mechanisms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00314798
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