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  • 1
    Electronic Resource
    Electronic Resource
    Interferon-alfa corrects thrombocytosis in patients with myeloproliferative disorders (1987)
    Springer
    Cancer immunology immunotherapy 25 (1987), S. 266-273 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During previous therapeutic trials with interferon, decreased levels of peripheral platelet counts have been observed. Taking advantage of this effect, we investigated the efficacy of recombinant interferon (rec-IFN) in the treatment of thrombocytosis in myeloproliferative diseases. A total of 15 patients with polycythemia vera, essential thrombocytosis, or chronic myeloid leukemia received rec-IFN-alfa at initial doses of 25–70×106 units/week; maintenance therapy following week 8 of treatment consisted of 20–35×106 units/week rec-IFN. Observation periods ranged from 24 to 48 weeks. Significant reductions in the number of platelets were noted in all cases; 12/15 patients achieved platelet counts below 440×109/1 and maintained those normal values for at least 4 weeks. The number of bone marrow megakaryocytes, which had been increased prior to treatment, diminished during rec-IFN therapy, while the previously shortened platelet half-life further decreased with rec-IFN treatment. During rec-IFN-induced remission, the plasma levels of platelet factors, the activity of natural killer cells, and platelet aggregation showed changes between slight improvement and normal values. Severe side effects were only observed with the highest rec-IFN doses; dosage adjustments were effective in improving or eliminating all treatment-related symptoms. Rec-IFN may prove to be a valuable therapeutic alternative to cytostatic treatment of thrombocytosis in myeloproliferative disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199157
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  • 2
    Electronic Resource
    Electronic Resource
    The puff-specific Drosophila protein Bj6, encoded by the gene no-on transient A, shows homology to RNA-binding proteins (1990)
    Springer
    Chromosoma 100 (1990), S. 37-47 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The DNA coding for the puff-specific protein Bj6 has been isolated by expression cloning. The gene is localized in 14C1,2 on the X chromosome and is expressed ubiquitously during embryonic development with prominent expression during the first 12 h of embryogenesis. cDNA and genomic clones have been sequenced and show a single open-reading frame of 2.1 kb length, coding for a Mr=77000 basic protein. In the aminoterminal half of the protein we detect stretches of repeated amino acids, centrally a region with homology to RNA-binding proteins containing the RNP 1 and RNP 2 consensus motif of RNA binding proteins, and the carboxyterminal part is rich in charged amino acids. The Bj6 protein is a product of the gene no-on transient A, a gene required for normal vision and courtship behaviour in Drosophila.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00337601
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Maximal androgen blockade in combination with methotrexate for treatment of metastatic prostate cancer (1996)
    Springer
    Journal of cancer research and clinical oncology 122 (1996), S. 171-176 
    Details
    ISSN: 1432-1335
    Keywords: Prostate cancer ; Maximal androgen blockade ; Methotrexate ; Randomized trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently attention has been focused on the optimal timing of chemotherapy within the treatment regimen for patients with metastatic prostate cancer, i.e., hormonal manipulation, preferably maximal androgen blockage (MAB) consisting of chemical/surgical castration followed by treatment with antiandrogens. We have conducted a randomized prospective clinical trial, investigating the efficacy and toxicity of MAB (orchiectomy followed by flutamide therapy) alone as compared to MAB combined with methotrexate (MTX, 50 mg/m2/week) in 53 patients with newly diagnosed stage IV (M1) prostatic cancer (UICC TNM Classification 1987). The observed remission rates (complete+partial) of 42.3% in the MAB+MTX arm and 29.6% in the MAB arm did not differ significantly. The response rates (complete+partial+stable disease) of 73.1% and 66.7% for MAB+MTX and MAB, respectively, also showed no significant difference. Neither progression-free survival (median: 18.5 and 23.8 months for MAB+MTX and MAB, respectively) nor overall survival (median: 37.4 and 36.1) months in the MAB+MTX and MAB arm, respectively) could be improved by the addition of MTX to MAB. Only the extent of metastatic pain reported by the patients was consistently less under MAB+MTX than under MAB alone (P〈0.1). Both treatment regimens were well-tolerated with slightly more undesirable effects in the MAB+MTX arm. Our results do not provide evidence for the achievement of marked gains by combining chemotherapy with endocrine therapy in newly diagnosed patients with stage IV (M1) prostate cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01366958
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  • 4
    Electronic Resource
    Electronic Resource
    Die Trocknung von tert-Butylhydroperoxid nach einem einfachen, erstmals gefahrlosen Verfahren (1980)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 113 (1980), S. 3662-3665 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A Simple, Non-hazardous Procedure for the Preparation of Absolute tert-Butyl Hydroperoxide from 80% Aqueous SolutionsThe preparation of absolute tert-butyl hydroperoxide (〈 0.01 mol/l H2O) from commercial 80% aqueous solutions is reduced to a simple experimental procedure by the use of 3Å molecular sieves. In contrast to the usual methods, there is no risk of explosion. A simple color test for the determination of the residual water content is described.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19801131124
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  • 5
    Electronic Resource
    Electronic Resource
    Eine einfache Synthese von TetramethyloxamidKarl Dimroth zum 70. Geburtstag gewidmet. (1981)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1981 (1981), S. 1015-1017 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: A Simple Synthesis of TetramethyloxamideTetramethyloxamide has been prepared by a new and simple procedure from dimethylformamide, iron(II) sulfate heptahydrate, and tert-butyl hydroperoxide (yield 43%) or 30% aqueous hydroperoxide (yield 77%).
    Notes: Es wird eine neue, einfache Synthese von Tetramethyloxamid aus Dimethylformamid, Eisen(II)-sulfat-heptahydrat und tert-Butylhydroperoxid (Ausb. 43%) oder 30proz. Wasserstoffperoxid (Ausb. 77%) beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198119810606
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