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  • 1
    Electronic Resource
    Electronic Resource
    Positron Emission Tomography Study of the Alterations in Brain Distribution of [11C]Methamphetamine in Methamphetamine-Sensitized Dog (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 801 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: We newly prepared a MAP-sensitized dog by repeated MAP treatment and studied the brain distribution of [11C]MAP in the normal and the MAP-sensitized dog using PET. The maximal level of accumulation of [11C]MAP in the sensitized dog brain was 1.4 times higher than that in the control. No difference was found in the metabolism of MAP between the two conditions. The significant increase of [11C]MAP in the MAP-sensitized brain indicates that subchronic MAP administration causes some functional change in the uptake site of MAP. The pharmacokinetic change may, in part, account for behavioral sensitization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb17462.x
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  • 2
    Electronic Resource
    Electronic Resource
    Assessment of radiotherapeutic effects on experimental tumors using 18F-2-fluoro-2-deoxy-D-glucose (1986)
    Springer
    European journal of nuclear medicine 12 (1986), S. 325-328 
    Details
    ISSN: 1619-7089
    Keywords: 18F-fluorodeoxyglucose ; Tumor glucose uptake ; Assessment of radiotherapeutic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study is to evaluation the effect of tumor volume and radiotherapy on the uptake of 18F-2-fluoro-2-deoxy-D-glucose (18FDG). The tumor models used were mouse mammary carcinoma MM48, FM3A, and rat hepatoma AH109A. Results were expressed as an 18FDG uptake ratio. This was the ratio of irradiated tumor uptake of 18FDG to unirradiated tumor uptake. The total tumor uptake was expressed as 18FDG uptake ratio multiplied by relative tumor volume. Following 20 Gy irradiation of the radioresistant tumor (MM48), the 18FDG uptake ratio was found to be unchanged, whereas in radiosensitive tumors (FM3A) the 18FDG uptake ratio was 0.37, the relative tumor volume was 0.31, and the calculated total tumor uptake was 0.11 on the eighth day after irradiation. The total tumor uptake was lower than the relative tumor volume. AH109A began to regrow after ten Gy irradiation, accompanied by elevated uptake of 18FDG on the seventh day. These results suggest that the 18FDG uptake by tumor is a good marker of radiotherapeutic effects as well as relapses of cancers and is more sensitive than morphological methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263812
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  • 3
    Electronic Resource
    Electronic Resource
    Evaluation of the treatment response of lung cancer with positron emission tomography and l-[methyl-11C]methionine: a preliminary study (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 495-501 
    Details
    ISSN: 1619-7089
    Keywords: Positron emission tomography ; Lung cancer ; Computed tomography ; Carbon-11 methionine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We carried out a study to evaluate treatment response and residual mass in lung cancer with positron emission tomography (PET), using l-[methyl-11C]methionine (MET). MET tumour uptake and tumour volume measured by computed tomography (CT) before and within 2 weeks after radiotherapy or chemoradiotherapy were compared in 43 studies of 21 patients. Ten patients with local control (no recurrence) of tumour showed a larger decrease in MET uptake (65.2%±12.2%) than in tumour volume (50.8%±9.6%, P〈0.01). Five patients with early recurrence (from 1 to 4 months) showed smaller decreases in both MET uptake (22.2%±13.5%) and tumour volume (28.6%±20.0%) than those in the no-recurrence group (P〈0.01). Four patients with late recurrence (after 11 months or more) showed a similar decrease to the no-recurrence group in MET uptake (72.8%±14.8%) but little change in tumour volume (18.5%±19.0%), the latter result corresponding to that in the early-recurrence group. Using tumour volume only, the no-recurrence group was differentiated from both the early- and the late-recurrence group (P 〈 0.01), but the early-recurrence group was not differentiated from the late-recurrence group. Using the MET uptake data, the early-recurrence group was clearly distinguished from the late-recurrence group (P〈0.01), but the late-recurrence group was indistinguishable from the no-recurrence group. CT was useful in distinguishing the no-recurrence group from the groups in which there was ultimate recurrence, whether early or late. When a residual mass is seen on CT, PET seems to be helpful in evaluating tumour viability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175162
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  • 4
    Electronic Resource
    Electronic Resource
    Regional coupling of blood flow and methionine uptake in an experimental tumor assessed with autoradiography (1988)
    Springer
    European journal of nuclear medicine 14 (1988), S. 388-392 
    Details
    ISSN: 1619-7089
    Keywords: Blood flow ; Methionine uptake ; Rat Tumor ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Regional distribution of L-[methyl-14C] methionine (14C-MET) and 4-[18F] fluoro-antipyrine was compared using experimental rat tumors (AH109A) and a computerized autoradiogram image processor. Tissue distributions of the two tracers were found to be inhomogeneous in the tumor with nearly identical image patterns. Analysis of tissue radioactivities revealed that 82% of 14C-MET was derived from the acid insoluble fraction at 60 min after injection. The present study showed that 14C-MET uptake closely relates to tissue blood flow and may depend on its blood to tissue transport. Rapid incorporation of MET in the acid insoluble fraction implies that it is rapidly metabolized after transport into tumor tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254390
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  • 5
    Electronic Resource
    Electronic Resource
    Estimation of absorbed dose for 2-[F-18]fluoro-2-deoxy-d- glucose using whole-body positron emission tomography and magnetic resonance imaging (1998)
    Springer
    European journal of nuclear medicine 25 (1998), S. 565-574 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Absorbed Dose ; S-value ; MIRD phantom ; Whole-body positron emission tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to measure the cumulated activity and absorbed dose in organs after intravenous administration of 2-[F-18]fluoro-2-deoxy-d-glucose (18F-FDG) using whole-body positron emission tomography (PET) and magnetic resonance imaging (MRI). Whole-body dynamic emission scans for 18F-FDG were performed in six normal volunteers after transmission scans. The total activity of a source organ was obtained from the activity concentration of the organ measured by whole-body PET and the volume of that organ measured by whole-body T1-weighted MRI. The cumulated activity of each source organ was calculated from the time-activity curve. Absorbed doses to the individuals were estimated by the MIRD (medical internal radiation dosimetry) method using S-values adjusted to the individuals. Another calculation of cumulated activities and absorbed doses was performed using the organ volumes from the MIRD phantom and the ”Japanese reference man” to investigate the discrepancy of actual individual results against the phantom results. The cumulated activities of 18 source organs were calculated, and absorbed doses of 27 target organs estimated. Among the target organs, bladder wall, brain and kidney received the highest doses for the above three sets of organ volumes. Using measured individual organ volumes, the average absorbed doses for those organs were found to be 3.1×10–1, 3.7×10–2 and 2.8×10–2 mGy/MBq, respectively. The mean effective doses in this study for individuals of average body weight (64.5 kg) and the MIRD phantom of 70 kg were the same, i.e. 2.9×10–2 mSv/MBq, while for the Japanese reference man of 60 kg the effective dose was 2.1×10–2 mSv/MBq. The results for measured organ volumes derived from MRI were comparable to those obtained for organ volumes from the MIRD phantom. Although this study considered 18F-FDG, combined use of whole-body PET and MRI might be quite effective for improving the accuracy of estimations of the cumulated activity and absorbed dose of positron-labelled radiopharmaceuticals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050257
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  • 6
    Electronic Resource
    Electronic Resource
    Estimation of internal absorbed dose of l-[methyl-11C]methionine using whole-body positron emission tomography (1998)
    Springer
    European journal of nuclear medicine 25 (1998), S. 629-633 
    Details
    ISSN: 1619-7089
    Keywords: Key words:l-[Methyl-11C]methionine ; Whole-body positron emission tomography ; Cumulated activity ; Absorbed dose ; MIRD method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. l-[Methyl-11C]-methionine (11C-methionine) is proposed as a useful radiotracer for tumour diagnosis. Human biodistribution data of cumulated activities and absorbed doses estimated by the MIRD (medical internal radiation dosimetry) method for 11C-methionine are not available in the literature. In this study we measured the organ activity for 11C-methionine by using whole-body positron emission tomography (PET) and estimated the absorbed doses to 25 organs by the MIRD method. Whole-body dynamic PET scans were performed on five normal volunteers to measure the time course of the organ activity concentration (activity/volume) after intravenous administration of 11C-methionine. Cumulated activities of the ten source organs were calculated from the time-activity curves, obtained from the dynamic PET data. Absorbed dose estimates were performed by the MIRD method for the Caucasian reference man and for the Japanese reference man. The organs which received the highest absorbed doses for the Caucasian reference man were found to be the bladder wall (2.7×10–2 mGy/MBq), the pancreas (1.9×10–2 mGy/ MBq), the liver (1.8× 10–2 mGy/MBq) and the kidney (1.1×10–2 mGy/MBq). The effective doses for the Caucasian reference man and the Japanese reference man were calculated as 5.2×10–3 and 5.0×10–3 mSv/MBq, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050265
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  • 7
    Electronic Resource
    Electronic Resource
    Experimental pancreas imaging study with 13N-glutamate using positron computer tomography (1983)
    Springer
    European journal of nuclear medicine 8 (1983), S. 528-530 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Accumulation of 13N-l-glutamate in the pancreas was experimentally evaluated by tissue distribution studies and by positron computer tomography imaging studies. The pancreas and salivary gland of Donryu rats exhibited a high rate of 13N-glutamate uptake. The percent administered dose/g of pancreas was 3.8 at 20 min, 4.4 at 30 min after injection, and the pancreas to liver ratio was 1.9 and 2.5, respectively. The same results were obtained with Golden hamsters. The role of the feeding protocols was studied to optimize the technique. The fasting group showed a significantly higher uptake in the pancreas than in the free feeding group. The uptake in the fasting followed by a high protein meal group was higher than fasting only group, but the difference was not significant. Positron emission tomography of a miniature-pig with 13N-glutamate showed a clear image of the pancreas with the highest activity. It was concluded that 13N-glutamate was quite useful in positron imaging of the pancreas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251614
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  • 8
    Electronic Resource
    Electronic Resource
    Tumor detection with carbon-11-labelled amino acids (1984)
    Springer
    European journal of nuclear medicine 9 (1984), S. 136-140 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A comparative study of tumor detection with ten 11C-labeled amino acids including four newly synthesized amino acids was carried out to find the most valuable 11C-labeled amino acid for the diagnosis of cancer. 11C-l-methionine showed the highest uptake by the experimental rat hepatoma AH109A (2.7% administered dose/g at 20 min, tumor to blood ratio; 11.4). The second highest uptake was of 11C-aminocyclopentane-carboxylic acid (ACPC). The newly synthesized 11C-dl-methyl-ACPC characteristically showed higher accumulation in tumor than in liver and the tumor to liver ratio reached 3.0 at 60 min after injection. It is suggested that 11C-l-methionine and 11C-dl-methyl-ACPC are useful amino acids for the diagnosis of cancer using positron emission tomography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253516
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