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  • 1
    Electronic Resource
    Electronic Resource
    Acute widespread oedema, hypoproteinaemia and generalized morphoea (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 30 (2005), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.2005.01747.x
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  • 2
    Electronic Resource
    Electronic Resource
    The Physiology of Calcitonin Gene—Related Peptide in the Islet Compared with That of Islet Amyloid Polypeptide (Amylin) (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 657 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb22777.x
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  • 3
    Electronic Resource
    Electronic Resource
    Diabetic neuropathy in the upper limb and the effect of twelve months sorbinil treatment (1988)
    Springer
    Diabetologia 31 (1988), S. 214-220 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic neuropathy ; aldose reductase inhibitor ; clinical trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical and neurophysiological studies were undertaken, with particular reference to the arms, in 39 patients with diabetic neuropathy. The effects of an aldose reductase inhibitor, sorbinil, on neuropathy in these patients were studied in a 12 month double blind placebo controlled trial. Neurophysiological measurements, particularly of sensory amplitude, were considerably more sensitive than measurements of temperature and vibration sensation and remain of fundamental importance in measuring diabetic neuropathy at an early and potentially reversible stage. There was no significantly beneficial effect of sorbinil on clinical or neurophysiological measurements of nerve function in patients with established diabetic neuropathy. These results indicate that neurophysiological techniques are necessary, in conjunction with clinical measurements, for the assessment of ‘early’ diabetic neuropathy and that aldose reductase inhibitors are not effective in the treatment of established diabetic neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290587
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  • 4
    Electronic Resource
    Electronic Resource
    Lack of acute effect of amylin (islet associated polypeptide) on insulin sensitivity during hyperinsulinaemic euglycaemic clamp in humans (1994)
    Springer
    Diabetologia 37 (1994), S. 166-169 
    Details
    ISSN: 1432-0428
    Keywords: Key words Amylin, insulin sensitivity, euglycaemic clamp, humans.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It is suggested that amylin (islet associated polypeptide), co-secreted with insulin from the pancreatic beta cells acts as a circulating hormone which opposes the action of insulin on muscle and increases hepatic glucose production. We have tested the effect of amylin in human subjects on postabsorptive glucose homeostasis and on insulin sensitivity using the euglycaemic hyperinsulinaemic clamp. The amylin used opposed insulin-mediated glucose disposal in rat soleus muscle at concentrations of 10 nmol/l. Seven subjects were studied on two occasions and infused with either amylin or placebo for 6 h, initially when postabsorptive and then during a euglycaemic hyperinsulinaemic clamp. Mean plasma amylin concentrations during the first 3 h were 2006±327 pmol/l during amylin infusion and 20±9 pmol/l during the control infusion. Amylin infusion had no effect on postabsorptive plasma concentrations of insulin (control: 32±16 vs amylin: 25±8 pmol/l) or glucose (5.1±0.1 vs 5.3±0.1 mmol/l). During the clamp, amylin concentrations were 1636 ±422 pmol/l when it was infused and 24±6 during control infusions. Plasma glucose and insulin concentrations were well matched during the control and amylin infusions (glucose: 4.7±0.1 vs 4.8±0.1 mmol/l; insulin: 198±37 vs 195±22 pmol/l). Exogenous glucose infusion rates were a mean of 13 % lower than control values during the amylin infusion but were not statistically different (p =0.17). Therefore, an approximately 100-fold elevation of plasma amylin concentration failed to consistently alter glucose metabolism. Our data suggest that amylin does not act as a circulating hormone to influence glucose metabolism in humans. [Diabetologia (1994) 37: 166–169]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050088
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  • 5
    Electronic Resource
    Electronic Resource
    Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient (1988)
    Springer
    Diabetologia 31 (1988), S. 158-161 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; insulin ; localised amyloidosis ; amino acid sequence analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A patient with Type 1 (insulin-dependent) diabetes mellitus developed localised amyloidosis at the sites of his injections of porcine insulin. A major amyloid fibril protein was extracted and, by means of its amino acid composition and amino acid sequence, it was shown to contain intact insulin molecules. Porcine insulin is the tenth protein and the first foreign protein to be chemically identified in human amyloid fibrils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276849
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  • 6
    Electronic Resource
    Electronic Resource
    Pattern of myelinated fibre loss in the sural nerve in neuropathy related to Type 1 (insulin-dependent) diabetes (1988)
    Springer
    Diabetologia 31 (1988), S. 162-167 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic neuropathy ; hereditary motor and sensory neuropathy ; sural nerve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sural nerve biopsies were obtained from 17 diabetic patients with neuropathy. All patients except three had both a symmetric distal sensory and autonomic polyneuropathy related to Type 1 (insulin-dependent) diabetes mellitus; 3 patients had a purely sensory polyneuropathy. Mean age was 34.5 years (range 18–53 years). The biopsies were compared with specimens from an age-matched control series. Myelinated fibre loss in the diabetic nerves was found to be nonuniform. Although patchy fibre loss has been considered to favour a vascular basis, an identical pattern of nonuniform loss was observed in a series of sural nerve biopsies from patients with Type I hereditary motor and sensory neuropathy, a subgroup within the spectrum of peroneal muscular atrophy, mainly of autosomal dominant inheritance, and a condition in which a vascular causation can be discounted. Possible reasons for nonuniform fibre loss other than vascular disease are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276850
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Failure to establish islet amyloid polypeptide (amylin) as a circulating beta cell inhibiting hormone in man (1990)
    Springer
    Diabetologia 33 (1990), S. 115-117 
    Details
    ISSN: 1432-0428
    Keywords: Islet amyloid polypeptide ; man ; intravenous glucose tolerance test ; Type 2 (non-insulin-dependent) diabetes mellitus ; radioimmunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of islet amyloid polypeptide in amyloid within pancreatic islet cells in Type 2 (non-insulin-dependent) diabetes, and its reported inhibition of glucose uptake by skeletal muscle in vitro, has prompted speculation concerning its role in the pathogenesis of diabetes. We investigated the effect of infused synthetic amidated human islet amyloid polypeptide (mol. wt. 3904, confirmed by mass spectroscopy) on intravenous glucose tolerance. Seven healthy, non-obese volunteers (age±SD, 27±4 years) were infused over 50 min with normal (0.9%) saline or islet amyloid polypeptide at 50 pmol·kg−1·min−1. After 20 min, a bolus of 0.5 g/kg glucose was given within 1 min and blood sampling continued for up to 60 min. Circulating concentrations of islet amyloid polypeptide reached at steady state were 1130±90 pmol/l. The calculated half-life was 11.8±0.9 min, metabolic clearance rate 5.7±0.6 ml·kg−1·min−1 and apparent distribution space therefore 94±12 ml/kg. However, islet amyloid polypeptide was found to have no effect on the peak value reached, or the total area under the curve for plasma glucose, insulin or glucagon following intravenous glucose. This study suggests circulating islet amyloid polypeptide may not be an important influence on intravenous glucose tolerance in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401050
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