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  • 1
    Electronic Resource
    Electronic Resource
    Sulphamethoxazole/trimethoprim: Pharmacokinetic studies in patients with chronic renal failure (1972)
    Springer
    European journal of clinical pharmacology 4 (1972), S. 233-240 
    Details
    ISSN: 1432-1041
    Keywords: Sulphamethoxazole ; trimethoprim ; pharmacokinetics ; uraemia ; sulphonamides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of sulphamethoxazole (SMZ) and trimethoprim (TMP) have been investigated in four healthy volunteers, 15 patients with stable chronic renal failure and 3 patients on regular dialysis. The dosage schedule was 400 mg of SMZ and 80 mg of TMP orally every 12 h. The plasma concentrations and urinary excretion have been analysed in terms of a one compartment open model, allowing for elimination by renal excretion and metabolic processes. — At equilibrium the plasma concentrations of unchanged sulphonamide showed no significant correlation with the degree of renal impairment. The accumulation of TMP increased slightly without affecting the concentration ratio of both agents in plasma. In contrast, increasing accumulation of metabolized SMZ was demonstrated in the presence of renal insufficiency. Indirect evidence indicates that rising metabolite levels under these circumstances may lead to a displacement of unchanged sulphonamide from protein binding sites. — The cumulative urinary excretion amounted to 82.4% of the dose of sulphonamide administered, which probably corresponds to the fraction of the compound absorbed. The urinary concentration of biologically active SMZ was slightly below the plasma level, especially in advanced renal failure, but it remained above the minimum inhibitory concentrations reported in the literature. The concentration of TMP in urine was considerably higher than in plasma, it decreased with loss of renal function as did active SMZ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00635802
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  • 2
    Electronic Resource
    Electronic Resource
    Elektronenmikroskopische Befunde bei der sog. membranoproliferativen Glomerulonephritis (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 888-895 
    Details
    ISSN: 1432-1440
    Keywords: Membrano-proliferative Glomerulonephritis ; filamentous transformation of the intercellular substance ; Membrano-proliferative Glomerulonephritis ; Elektronenmikroskopie ; filamentäre Transformation der Intercellularsubstanz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 5 Patienten mit der lichtmikroskopisch gestellten Diagnose einer membranoproliferativen Glomerulonephritis wurden elektronenmikroskopische, immun-histologische und immunologische Untersuchungen angestellt. Im Ultradünnschnitt erwies sich die charakteristische Lobulierung der Glomeruli als Folge einer besonderen filamentären Transformation der Intercellularsubstanz, die Anlaß gab, eine Ablagerung von Amyloid bzw. einer amyloidähnlichen Substanz zu vermuten. Immunhistologisch imponierte eine ubiquitäre Präcipitation IgG-haltiger Immunkomplexe. Diese Befunde werden unter dem Aspekt der Amyloidentstehung aus den variablen Endketten von Immunglobulinen diskutiert. Im Anschluß an die Darstellung des klinischen Verlaufs und der morphologischen Veränderungen wird zur Frage einer möglichen therapeutischen Beeinflussung Stellung genommen.
    Notes: Summary In five patients with light microscopic diagnosis of “membrano-proliferative glomerulonephritis” electron microscopic, immunohistological, and immunological studies were performed. By ultrastructural analysis the increase of mesangial intercellular substance was characterized as deposition of amyloid or an amyloid like substance. In addition, immuno-histological data showed ubiquitary localisation of immune deposits in the glomeruli. These findings are discussed from the viewpoint of an immunoglobulin origin of amyloid. Following a report of the clinical course controversial issues regarding therapy are pointed out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468616
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibition of hepatitis B virus specific DNA polymerase by intercalating agents (1980)
    Springer
    Medical microbiology and immunology 168 (1980), S. 25-34 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intercalating agents, some of them in clinical use, were tested for their ability to inhibit the hepatitis B virus specific DNA polymerase reaction. Ethidium bromide was shown to be the strongest inhibitor among the compounds tested. Compounds in clinical use inhibited the DNA polymerase test only at high concentrations. The inhibitory activity of all compounds tested was increased when the MgCl2 content in the reaction mixture was lowered. UV absorption studies presented no evidence that this effect was due to complex formation of magnesium and the individual compounds. The therapeutic significance of these findings is not certain and needs further work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02121649
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    Paper (German National Licenses)
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