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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: HLA-DPB1 allele frequencies in 181 unrelated control individuals and 70 rheumatoid factor-positive RA patients from Seville (Spain) were determined using oligonucleotide typing methods. All frequencies shown concern the percentage of individuals positive for a certain allele. HLA-DPB1*0401 was the most common DPB1 allele in the healthy individuals, possessed by 65.7% of them. In addition to HLA-DPB1 *0401, only the following alleles were found in normal subjects at frequencies greater than 10%: DPB1*0101 (15.5%), DPB1*0201 (12.2%), DPB1*0301 (16.6), and DPB1*0402 (29.3%). When HLA-DPB1 allelic frequencies were compared between seropositive RA patients and controls, a negative association for DPB1*0301 and DPB1*0401 was found in RA patients, although it failed to reach statistical significance after correction for the number of comparisons made. The other DPB1 alleles exhibited almost identical frequencies in both groups. However, when only DR4+ patients and controls were considered, the decrease in the frequency of the DPB1*0301 and DPB1*0401 alleles lacked statistical significance. On the other hand, when DR4- RA patients and controls were compared, the frequency of DPB1*0301 was found decreased significantly again, even more than in the whole group of patients.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 12 (1997), S. 261-266 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Nous décrivons une technique personnelle de procto-colectomie avec rétablissement de la continuité au moyen d'une anastomose iléo-anale complétée de multiples myotomies (SIAM) réalisées chez 15 patients dont 9 sont affectés d'une polypose familiale et 6 (femmes) d'une colite ulcéreuse (UC). Technique chirurgicale: Huit à dix myotomies de 3 à 4 cm de longueur sont réalisées sur 3 emplacements longitudinaux distincts de l'iléon terminal, sur une longueur totale de 12 à 14 cm. Résultats cliniques: A 44 mois en moyenne (3 à 84 mois) après la fermeture de l'iléostomie, une continence diurne est achevée chez tous les patients avec une fréquence d'exonération par 24 heures (±SD) de 4,1±1,8 chez les patients atteints de FAP et 5,8±1,6 chez les patients porteurs de UC; les exonérations nocturnes sont de 1,0±0,5 en cas de FAP et 1,2±0,8 en cas de UC. Les pertes nocturnes sont pré-sentes chez 2/5 des patients atteints de UC et chez 3/9 des patients atteints de FAP. La SIAM échoué chez un patient porteur de UC chez lequel l'anastomose a dûêtre convertie en réservoir iléo-anal en raison du mauvais résultat fonctionnel. Nous n'avons jamais observé d'inflammation de la muqueuse iléale à l'endocospie. L'examen histologique n'a pas montré d'iléite terminale aiguë. Constatations manométriques: une diminution significative de la pression de repos a été observée après SIAM. Ni l'absence de réflexe ano-inhibiteur ni la présence d'ondes de haute pression produites dans l'iléon terminal par l'insufflation d'air n'a pu être mise en relation avec un soiling. La fermeture de l'iléostomie latérale a été suivie d'une augmentation de la capacité de la distensibilité de l'iléon terminal. Les valeurs de la compliance du néo-rectum ont été analogues en cas de FAP et de UC bien que les patients porteurs de FAP aient atteint des valeurs plus élevées de seuil maximum tolérable et de pression rectale. Conclusion: Le SIAM peut être une alternative à la confection d'une poche iléo-anale pelvienne chez des patients qui ont subi une procto-colectomie chez lesquels la confection d'une poche n'est pas possible. Les résultats fonctionnels observés après SIAM sont analogues à ceux observés après poche iléo-anale.
    Notes: Abstract . An alternative technique of restorative proctocolectomy, by means of straight ileoanal anastomosis with multiple myotomies (SIAM) of the terminal ileum in 15 patients, nine with familial adenomatous polyposis (FAP) and six with ulcerative colitis (UC) is reported. Surgical technique: eight to ten longditudinal myotomies (3 – 4 cm long, on three different circumferential sites) were performed on the terminal ileum for a total length of 12 – 14 cm. Clinical results: at a mean follow up of 44 months (range 3 – 84 months) from the closure of the ileostomy, daytime continence was achieved in all the patients; stool frequency per 24 hours (±SD) was 4.1±1.8 for FAP patients and 5.8±1.7 for UC patients; nocturnal defecation was 1.0±0.5 and 1.2±0.8 for FAP and UC patients respectively; frequent nocturnal soiling was present in 2/5 of UC patients, and in 3/9 of FAP patients. SIAM failed in one UC patient that was converted to an ileoanal reservoir because of poor functional result. Signs of ileal mucosal inflammation were never observed at endoscopic examination. Histopathological assessment showed no evidence of acute terminal ileitis. Manometric findings: a significant postoperative reduction in anal resting pressure was observed after SIAM. Neither the absence of anal inhibitory reflex nor the presence of high pressure waves generated in the terminal ileum during air insufflation were related to the presence of soiling. The closure of the loop ileostomy was followed by an increased capacity and distensibility of the terminal ileum. Values of neorectal compliance were similar in FAP and UC patients although FAP patients were able to reach higher values of maximum tolerated volume and pressure. Conclusions: 1) SIAM can be an alternative to pelvic pouch in patients who have undergone restorative proctocolectomy when the construction of the pouch is not feasible. 2) The functional result observed after SIAM has been shown to be similar to that observed after pouch construction.
    Type of Medium: Electronic Resource
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