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  • 1
    Digitale Medien
    Digitale Medien
    Granulomatöse Endokarditis durch Streptokokken (1994)
    Springer
    Der Pathologe 15 (1994), S. 40-43 
    Details
    ISSN: 1432-1963
    Schlagwort(e): Schlüsselwörter: Granulomatöse Entzündung – Endokarditis – Streptokokken ; Key words: Granulomatous infection – Endocarditis – Streptococci
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Abstract. Two cases of granulomatous endocarditis are reported. The patients developed aortal endocarditis refractory to antibiotics. Therefore, aortal valve replacement was performed. In both cases, Streptococcus viridans was demonstrated in culture and bacterioscopically to be the cause of infection. Histological examination of the valves showed characteristic endocarditis with fibrinoid necrosis and histiocytic granulomas. Streptococci were found in the cytoplasm of macrophages. The possible causes of this special form of infectious endocarditis are discussed.
    Notizen: Zusammenfassung. Wir berichten über 2 Fälle von granulomatöser Endokarditis mit kulturellem Nachweis von vergrünenden, nicht hämolysierenden Streptokokken (Viridansgruppe). Bei beiden Patientinnen war eine Aortenklappenendokarditis mit Klappeninsuffizienz aufgetreten. Bei fehlendem Ansprechen auf die antibiotische Therapie wurde die Klappe operativ entfernt. In der Kultur und bakterioskopisch wurden Streptokokken der Viridansgruppe als Ursache der Endokarditis gesichert. Histologisch fanden sich histiozytäre Granulome im Klappenstroma mit intrazellulärem Keimwachstum. Mögliche Ursachen dieser Sonderform einer infektiösen Endokarditis werden diskutiert.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002920050023
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  • 2
    Digitale Medien
    Digitale Medien
    Immunohistochemically detected HER-2/neu-expression and prognosis in endometrial carcinoma (1997)
    Springer
    Archives of gynecology and obstetrics 259 (1997), S. 189-195 
    Details
    ISSN: 1432-0711
    Schlagwort(e): Key words: Immunohistochemistry ; HER-2/neu ; p53 ; Ki-S1 ; Endometrial carcinoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Expression of the HER-2/neu proto-oncogene product was looked for immunohistochemically in 222 endometrial carcinomas in a retrospective follow-up study. The intensity of protein expression was correlated with patient survival. Median follow-up time was 4.8 years. In 109 (49%) of 222 endometrial carcinomas there was aberrant expression of HER-2/neu. HER-2/neu-expression did not correlate with p53-expression and proliferation rate, as determined immunohistochemically by the monoclonal antibody Ki-S1. In univariate statistical analysis aberrant HER-2/neu expression was not predictive of adjusted survival (p = 0.18) and of disease-free survival (p = 0.42). In multivariate analysis HER-2/neu-expression was not found to be an independent prognosticator (p = 0.099) as compared to FIGO-stage (p = 0.0001), histologic grade (p = 0.00099) and proliferation rate (p = 0.0013). Therefore immunohistochemically detected expression of HER-2/neu seems not to be a clinical prognosticator in endometrial cancer.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004040050157
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  • 3
    Digitale Medien
    Digitale Medien
    Neurofibromatosis presenting as a severe systemic vasculopathy (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 107-109 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Key words: Neurofibromatosis – Hypertension – Bowel infarction – Aneurysm – Thrombosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. In a boy with neurofibromatosis type 1 (NF-1), hypertension, septic infection of an aneurysm in the deltoid muscle, bowel infarction, multiple arterial aneurysms and venous thrombosis occurred within a period of 6 weeks. Histologically, vascular neurofibromatosis of the small vessels of the gut was found. This unusual occurrence of a multitude of clinical features within a few weeks was caused by vascular neurofibromatosis. Awareness of this condition in patients with NF-1 may help the paediatrician to avoid unnecessary diagnostic procedures and to initiate appropriate symptomatic therapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01959219
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  • 4
    Digitale Medien
    Digitale Medien
    Neurofibromatosis presenting as a severe systemic vasculopathy (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 107-109 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Neurofibromatosis Hypertension ; Bowel infarction Aneurysm ; Thrombosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In a boy with neurofibromatosis type 1 (NF-1), hypertension, septic infection of an aneurysm in the deltoid muscle, bowel infarction, multiple arterial aneurysms and venous thrombosis occured within a period of 6 weeks. Histologically, vascular neurofibromatosis of the small vessels of the gut was found. This unusual occurrence of a multitude of clinical features within a few weeks was caused by vascular neurofibromatosis. Awareness of this condition in patients with NF-1 may help the paediatrician to avoid unnecessary diagnostic procedures and to initiate appropriate symptomatic therapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01959219
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  • 5
    Digitale Medien
    Digitale Medien
    Prevention of hepatitis B flare-up during chemotherapy using lamivudine: case report and review of the literature (1999)
    Springer
    Annals of hematology 78 (1999), S. 247-249 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words Lymphoma ; Chemotherapy ; Hepatitis B reactivation ; Lamivudine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Reactivation of chronic hepatitis B in patients receiving cytotoxic treatment for non-Hodgkin's lymphoma is well documented. We report a case of a patient with chronic hepatitis B who was treated by chemotherapy because of non-Hodgkin's lymphoma. After the second cycle of chemotherapy she developed a severe flare-up of hepatitis B. Liver biopsy revealed highly active hepatitis and confluent necroses. Within 3 weeks, the patient recovered spontaneously. Prophylactic treatment with lamivudine (Epivir,Glaxo-Wellcome, 150 mg b.i.d.) led to a decrease of HBV-DNA below the detection limit. Further chemotherapy was administered and autologous stem cell transplantation was successfully performed without another reactivation of hepatitis B. Antiviral treatment was stopped 16 weeks after stem cell retransfusion. So far, no further flare-up of hepatitis B has occurred and the patient's lymphoma has not relapsed. Thus, the case described here indicates a possible role of lamivudine in preventing hepatitis B flare-up during antineoplastic chemotherapy. We suggest that lamivudine be considered for prophylaxis against fulminant hepatitis in patients with chronic HBV infection undergoing high-dose antineoplastic therapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002770050510
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  • 6
    Digitale Medien
    Digitale Medien
    Primär extragenitale Manifestation eines malignen Müller-Mischtumors im Omentum majus (1996)
    Springer
    Der Chirurg 67 (1996), S. 1273-1275 
    Details
    ISSN: 1433-0385
    Schlagwort(e): Key words: Malignant mixed Müllerian tumour ; Extragenital manifestation ; Greater omentum. ; Schlüsselwörter: Maligner Müller-Mischtumor ; extragenitale Manifestation ; Omentum majus.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung. Maligne Müller-Mischtumore (MMMT) sind Tumore des weiblichen Genitaltrakts, die in sehr seltenen Fällen primär extragenital auftreten können. Es wird über eine 46 jährige Patientin mit einem MMMT berichtet, der primär vom Omentum majus ausging. In der Literatur sind bisher 19 Fälle einer primär extragenitalen Manifestation der MMMT beschrieben, davon einmal im Omantum majus. Klinisches Bild, Diagnostik, Therapie und Histologie werden beschrieben, die Genese des Tumors wird diskutiert.
    Notizen: Summary. Malignant mixed Müllerian tumours (MMMT) are tumours of the female genital tract which rarely occur in extragenital sites. We report a case of a 46-year-old female with MMMT with primary occurrence in the greater omentum. Only 19 cases of primary extragenital manifestation of this tumour are described in the literature. The clinical appearance, diagnosis, therapy, histological evaluation and histogenesis are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001040050139
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