ISSN:
1432-0533
Keywords:
Experimental Allergic Encephalomyelitis
;
Melengestrol Acetate
;
Progestational Effect
;
Glucocerticoid Effect
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The following steroids were administered to female Wistar rats (Manor Farms or Purina) either at the time of sensitization or later when experimental allergic encephalomyelitis (EAE) was established — melengestrol acetate (MGA®), medroxyprogesterone acetate (MPA or Provera®), hydrocortisone acetate (HCA), estradiol, estradiol cypionate, ethinyl estradiol, estriol, mestranol, testosterone cypionate and nortestosterone. In accord with published work (Greiget al., 1970) MGA proved to be an effective therapeutic agent for the treatment of EAE while HCA was less effective. Of the other steroids ineffective alone, did potentiate the action of HCA in reducing the paralysis. Histologically, the combination of MPA with HCA also was superior to either one alone in one experiment; in a second experiment of longer duration in which a higher dose of HCA was used there was little difference. None of the compounds or combinations of compounds was as effective as MGA (25 mg/kg/week for 3 weeks) in the treatment of EAE. This compound appears to have unique therapeutic effects, both clinically and histologically.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00685763
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