ISSN:
1432-2323
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. In a randomized study, prevention of goiter recurrence with l-thyroxine was compared with pure iodide substitution after thyroid surgery for nodular goiter in an iodine-deficient area. Altogether 107 patients were followed up for 52 weeks after thyroid resection. The thyroid volume was determined sonographically. Free thyroxine, total thyroxine, thyrotropin, thyroglobulin, and antibodies to thyroglobulin and thyroid peroxidase were measured. The thyroid volume decreased slightly over the course of a year in the two therapy groups. There was no significant difference between the two groups. Recurrences were seen with both l-thyroxine medication and iodide substitution. The thyroglobulin levels fell significantly over the 52-week follow-up period in the iodide group. Antibody formation was not observed under iodine substitution. In an area of iodine deficiency, substitution with iodide is just as effective as medicating the patients with l-thyroxine for preventing recurrences.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002689900186
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