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  • 1
    Electronic Resource
    Electronic Resource
    Intensification of GVHD prophylaxis interferes with the effects of pretransplant herpes virus serology on the occurrence of grades II–IV acute graft-versus-host disease (1992)
    Springer
    Annals of hematology 64 (1992), S. A137 
    Details
    ISSN: 1432-0584
    Keywords: Bone marrow transplantation ; Graft-versus-host-disease ; Herpes viruses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of pretransplant herpes virus serology on the occurrence of grades II–IV acute graft-versus-host disease (GVHD) were studied in 262 recipients and their HLA-identical family donors. In 131 recipients on standard GVHD prophylaxis (either methotrexate or cyclosporin A) significant effects were observed for donor HSV serology (seropositivity associated with increased risk for GVHD) and donor EBV serology (seronegativity associated with increased risk). However, these effects were nonsignificant in the other 131 recipients on intensified GVHD prophylaxis (i.e., methotrexate combined with cyclosporin A, in vivo anti-T-cell monoclonal antibodies, or various procedures to reduce the T-cell numbers in the transplants).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715367
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  • 2
    Electronic Resource
    Electronic Resource
    Epstein-Barr virus infection in allogeneic marrow grafting: lessons for transplant physicians and virologists (1992)
    Springer
    Annals of hematology 64 (1992), S. A162 
    Details
    ISSN: 1432-0584
    Keywords: Bone marrow transplantation ; Epstein ; Barr virus ; Infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between Epstein-Barr virus (EBV) and the host is profoundly disturbed by allogeneic bone marrow transplantation (BMT) because EBV resides in the recipient's hematopoietic system, which has to be destroyed in the majority of cases, and in the donor's hematopoietic system, i.e., the marrow graft. We have shown that EBV may be eradicated from some BMT recipients and that the virus may be transferred with the marrow graft. During the immediate post-transplant period oropharyngeal EBV excretion may occur which, by infecting passing B lymphocytes, may act as co-factor for acute graft-versus-host disease and help the virus to survive, despite the temporary depletion of its reservoir. The coexistence of totally different EBV strains in BMT recipients but not in healthy, untransfused controls, suggests that superinfection may by possible in case of immunodeficiency; alternatively, transfer of the virus by the reservoir itself (the B lymphocytes) might be the only effective route for superinfection. The generation of ‘variant’ strains during viral replication may form the basis of the vast polymorphism between wild-type EBV isolates in the population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715373
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease (1983)
    [s.l.] : Nature Publishing Group
    Nature 302 (1983), S. 159-161 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Pattern of lysis in CML in the patient's family. The patient's cytotoxic effector cells (see legend to Table 1) were tested against his family members. F, father; M, mother; P (2), patient; D (6), donor; 3, 4 and 5 are siblings haploidentical to the patient. The % lysis (which represents the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/302159a0
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  • 4
    Electronic Resource
    Electronic Resource
    Is aciclovir prophylaxis necessary after bone marrow transplantation? (1986)
    Springer
    Infection 14 (1986), S. 122-124 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 44 Empfängern von allogenen Knochenmarkstransplantaten, die Aciclovir ausschließlich therapeutisch erhalten hatten, wurde eine retrospektive Studie durchgeführt, um die Kosten-Nutzen-Beziehung für die Prophylaxe im Vergleich zur Frühtherapie zu bestimmen. Bei 15 der 33 Herpes-simplex-Virus-seropositiven Patienten traten nach Knochenmarkstransplantation 18 Herpes-simplex-Virus-Infektionen auf. Bei zehn klinisch symptomfreien Patienten wurde in Routinekulturen Herpes-simplex-Virus nachgewiesen. Patienten mit mukokutaner Herpesinfektion erhielten Aciclovir intravenös appliziert. Alle Infektionen sprachen rasch auf die Therapie an. Es läßt sich errechnen, daß eine Beschränkung auf den therapeutischen Einsatz des Medikamentes den Verbrauch von Aciclovir vermindert und somit die Behandlungskosten und das Risiko der Resistenzentwicklung gegen Aciclovir erniedrigt.
    Notes: Summary To assess the cost-effect relationship of aciclovir prophylaxis versus early treatment, we performed a retrospective study in 44 allogeneic bone marrow transplant recipients, who had only received aciclovir for therapeutic purposes. After bone marrow transplantation 18 herpes simplex infections occurred in 15 of the 33 patients who were seropositive for herpes simplex virus. In ten patients without clinical signs, routine viral cultures yielded herpes simplex virus. Aciclovir was given intravenously to the patients with mucocutaneous herpes infection. All infections responded rapidly. It can be calculated that restricting the drug to therapeutic use reduced the amount of aciclovir used, which in turn diminished the cost of treatment and the risk of aciclovir resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01643475
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    Paper (German National Licenses)
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