ISSN:
1573-8221
Keywords:
hydroxystyrenes
;
cytokines
;
endotoxin tolerance
;
macrophages
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Preincubation of resident macrophages with 25-hydroxycholesterol decreased the lipopolysaccharide-induced expression of mRNAs of tumor, necrosis factor and interleukin-1, while 7-ketocholesterol stimulated the expression of the tumor necrosis factor mRNA. Tolerant macrophages characterized by decreased tumor necrosis factor secretion in response to lipopolysaccharide have increased (in comparison with resident macrophages) content of 25-and 27-hydroxycholesterol.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02432803
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