ISSN:
1573-8221
Keywords:
congenital diabetes mellitus
;
hemineurin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Intragastral administration of hemineurin in a daily dose of 60 mg/kg for 70 days suppresses insulin secretion by the pancreas, increases glucose and lipid blood levels, and decreases glucose tolerance in female rats. Adult progeny of these females mated with intact males develops increased insulinemic reaction to glucose and glucose intolerance. The progeny of rats administered hemineurin in the same dose on days 11–19 of pregnancy develops latent dysfunction of β-cells manifesting itself after alimentary carbohydrate loading.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445090
Permalink