ISSN:
1573-8221
Keywords:
neurotoxin MPTP
;
conditioned reflex
;
dopamine
;
striatum
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract We compared the effects of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) on exploratory behavior and conditioning in C57B1 and outbred animals. Two intraperitoneal injections of MPTP suppressed the orienting and exploratory behavior in C57B1 (reductions of both horizontal and vertical motor activity), but not in outbred mice, and impaired conditioning. The data indicate the dopaminergic nature of learning disturbances and suggest that the MPTP model may hold a lot of promise for the search for new drugs for the treatment of cognitive disorders in Parkinsonism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02433416
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