ISSN:
1573-8221
Keywords:
tranquillizer
;
emotional stress
;
EEG
;
MR and MNRA rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The effect of 2-[2-(morpholin)ethylthio]-5-ethoxybenzimidazole (CM-346) on the EEG of MR and MNRA rats was compared with that of diazepam. Both CM-346 and diazepam reversed stress-induced changes in bioelectrical activity after intraperitoneal injection of 0.9% NaCl. In MR and MNRA rats both drugs decreased the EEG spectral power in the high-frequency θ-band (7.5–8.2 Hz). In MR rats, CM-346 increased the power of the low-frequency θ-rhythm (4.8–5.8 Hz) and the dominant activity peak (6.0–7.2 Hz) and decreased the spectral power in the 19–20 Hz band. The data suggest that CM-346 exerts antistressor and anxiolytic effects in animals with passive reactions to emotional stress.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02433407
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