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  • 1
    ISSN: 1433-8580
    Keywords: Calcium ; Intestinal absorption ; Vagotomy ; Gastrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of HSV (controls: sham), which induces hypergastrinemia, on duodenal Ca absorption was studied in “intact”, TPTX, PTX, and TX rats. Ca absorption was estimated by an in vivo loop technique. As this technique increased serum gastrin by the duodenal Ca load, gastrin was also measured in rats not subjected to evaluation of Ca absorption. Following vagotomy gastrin rose significantly in “intact” as well as in TPTX, PTX, and TX rats. Further, intraduodenal Ca increased gastrin both after sham and vagotomy. However, gastrin in vagotomized rats was significantly higher than in sham rats, too. Although duodenal Ca absorption was not altered by vagotomy in “intact” and in TX rats, it was significantly lowered in vagotomized TPTX and PTX rats. Pretreatment of TPTX rats by pentagastrin for 10 days or immediately preceding experiments did not change Ca absorption. In addition, serum parathyroid hormone was unchanged by vagotomy in “intact” rats as compared to sham controls. We conclude that (1) vagotomy does not influence the rate of duodenal Ca absorption in “intact” rats, (2) Ca absorption is lower after vagotomy only in the absence of parathyroid glands, and (3) this vagotomy effect is not mimicked by exogenous pentagastrin and therefore appears unrelated to endogenous postvagotomy gastrinemia.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 385 patients (83% men, 52% aged 16–30) with urogenital (UG) trauma were treated in 19 urological clinics between April 1984 and December 1986. In all, 41% of the accidents were due to traffic; 13% to work and sports each; 8% to sexual activities; and 6% to violence. The distribution of injury severity included 40% light, 21% moderate and 39% severe. Of 427 UG lesions, 27% were combined with intraabdominal and 24% with pelvic injuries. The kidneys were involved in 51% of cases and the bladder, urethra, penis and scrotum, including its content, in ca. 10% each. Of the renal traumas, 49% were ruptures; 48% contusions; and 7% hilar lesions,a nd in 6% the complete destruction of the organ occurred. In all, 76% of these traumas were treated conservatively, whereas 8% each required reconstruction or nephrectomy. Amongst the urethral ruptures, 46% were complete; 39% partial posterior; and 11% ruptures of the penile urethra. In 43% of cases the treatment was conservative and in 41% a primary reconstruction was carried out. All intraperitoneal (43%) and 2/3 of the extraperitoneal bladder ruptures (57%) were operated on. Gross hematuria was found in 73% of the renal, 83% of the vesical and 73% of the urethral injuries. Microhematuria occurred in 24%, 9% and 13% of cases, whereas no hematuria was found in 3%, 5% and 13% of the kidney, bladder and urethral injuries, respectively. The injury-relevant sensitivity of the imaging methods was computed to be 95% for cystograms, 91% for urethrograms and 83% for angiograms. When used to screen trauma patients, the sensitivity proved to be 69% for the CT scan, 55% for the intravenous pyelogram (IVP) and 54% for sonography. Overall, 37% of 161 complications involved the UG tract, followed by neurological complications, those due to the operation or treatment, to infections or to organ failure. In all, 11% of patients remained in the hospital for only 1 day; 50% for up to 13 days; 20% for 14–60 days; and 17% for 〉60 days.
    Type of Medium: Electronic Resource
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