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  • 1
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    The Unmaking of the President: Why Bush Lost (1993)
    Washington D.C., Wash. : Periodicals Archive Online (PAO)
    Policy Review. 63 (1993:Winter) 10 
    Details
    ISSN: 0146-5945
    Topics: Political Science
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:h334-1993-063-00-000003
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  • 2
    Electronic Resource
    Electronic Resource
    Conformationally constrained calcium channel blockers: Novel mimics of 1-benzazepin-2-ones
    Amsterdam : Elsevier
    Bioorganic and Medicinal Chemistry 1 (1993), S. 309-325 
    Details
    ISSN: 0968-0896
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0968-0896(00)82135-5
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  • 3
    Electronic Resource
    Electronic Resource
    Regional oxygen supply and consumption balance in experimental left ventricular hypertrophy (1990)
    Springer
    Basic research in cardiology 85 (1990), S. 575-584 
    Details
    ISSN: 1435-1803
    Keywords: aortic valvestenosis ; coronaryblood flow ; myocardialO 2 consumption ; cardiachypertrophy ; dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of the present study was to determine if the relationship between myocardial O2 supply and O2 consumption was preserved after prolonged pressure overload due to aortic valve stenosis. This was examined in anesthetized open-chest dogs in which the aortic valve was plicated 6 months previously. We measured coronary blood flow with radioactive microspheres and regional small vessel O2 saturation with microspectrophotometry, to obtain O2 supply, and O2 consumption. Regional O2 consumption was calculated as the product of flow and O2 extraction. The left ventricular weight/body weight ratio was 81% greater in the dogs with aortic valve stenosis. There were no hemodynamic differences between the groups except that left ventricular systolic pressure was 38±22 mm Hg greater than aortic in the hypertrophied group. Coronary blood flow did not differ between the control and hypertrophied groups nor were there subepicardial vs subendocardial differences. When maximal coronary flow was determined with chromonar (10 mg/kg), the flow increase was significantly attenuated in the hypertrophied subendocardium (242.1±82.3 (hypertrophy) vs 512.4±204.1 ml·min−1·100 g−1 (control)). There were no significant differences in O2 extraction or O2 consumption/g between control and hypertrophied animals. There was a significantly lower O2 supply/consumption ratio in the subendocardium compared to the subepicardium of both groups. However, the O2 supply/consumption ratio was not decreased by hypertrophy. Thus, despite significant hypertrophy, a loss of flow reserve and a high left ventricular pressure, O2 supply/consumption balance is preserved in valvular aortic stenosis at rest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907892
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of complement depletion on O2 supply and consumption in ischemic dog myocardium (1987)
    Springer
    Basic research in cardiology 82 (1987), S. 57-65 
    Details
    ISSN: 1435-1803
    Keywords: myocardium ; complement ; coronary blood flow ; ischemia ; myocardial O2 consumption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to determine whether depletion of serum complement can decrease the severity of an ischemic episode by improving regional O2 supply and conumption parameters in the ischemic region of the heart. Fourteen anesthetized dogs with serum complement intact or depleted (100 U/kg cobra venom factor given 8 hrs before) were subjected to left anterior descending coronary artery (LAD) occlusion for 6 hrs. Myocardial blood flows were determined before and 6 hrs after LAD occlusion using radioactive microspheres. Regional arterial and venous O2 saturations were determined using microspectrophotometry. In control animals, flow decreased from 122±42 to 13±14 ml/min/100 g (mean±SD) in the occluded LAD region. With complement depletion, LAD occlusion resulted in a flow reduction in the ischemic region (38±29 ml/min/100 g), but to a lesser degree than seen in the same region in control animals, especially in the subendocardium. O2 consumption was decreased in the ischemic region of both treatment groups, though O2 consumption was higher in this region in complement depleted animals compared to the values in control animals. The O2 supply/consumption ratio was decreased similarly in the ischemic region of control and complement depleted groups. Thus, with complement depletion, flow to the ischemic zone was improved but this region was still flow restricted. The flow increase during complement depletion was sufficient to allow an increased O2, utilization in the ischemic region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907053
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  • 5
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    Prelude to A Landslide: How grass-roots populism could help Republicans in 1996 (1993)
    Washington D.C., Wash. : Periodicals Archive Online (PAO)
    Policy Review. 66 (1993:Fall) 30 
    Details
    ISSN: 0146-5945
    Topics: Political Science
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:h334-1993-066-00-000003
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of the thromboxane A2 receptor antagonist SQ 29,548 on the severity of pacing-induced ischemia (1989)
    Springer
    Basic research in cardiology 84 (1989), S. 103-110 
    Details
    ISSN: 1435-1803
    Keywords: thromboxane A2 ; ischemia ; SQ 29,548
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of the thromboxane A2 (TXA2)/prostaglandin endoperoxide receptor antagonist, SQ 29,548 on pacing-induced ischemia was determined in anesthetized open-chest dogs. The dogs were subjected to a left anterior descending coronary artery (LAD) stenosis sufficient to result in ischemia as measured by epicardial ST-segment elevation only when the hearts were paced 70–80 beats/min above baseline. After a recovery (nonpacing) period, either 0.2 mg/kg+0.2 mg/kg/hr SQ29,548 or saline was infused i.v. The animals were subjceted to 5 min periods of pacing before and 10, 40 or 70 min after the initiation of drug or saline treatment. Before drug treatment, pacing+LAD stenosis resulted in significant ST-elevation in both groups (11.5±1.1 mV and 12.4±0.6 mV for saline and SQ 29,548 groups, respectively). During drug treatment, SQ 29,548 significantly reduced ST-elevation during pacing+stenosis at 40 and 70 min. At 70 min, ST-elevation was 4.9±1.7 mV for the SQ 29,548 group vs 10.8±1.2 mV for the saline group (p〈0.05). In separate experiments 0.2 mg/kg+0.2 mg/kg/hr SQ 29,548 antagonized the activity of a TXA2 mimetic, U-46,619, for femoral vasoconstriction, causing 100-to-200 fold rightward shifts in dose response relationships. Thus, a dose of SQ 29,548 capable of strong TXA2-receptor blockade reduced the scverity of ischemia, and this effect was independent of changes in arterial blood pressure and heart rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907007
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  • 7
    Electronic Resource
    Electronic Resource
    Propranolol and thyroxine-induced hypertrophic rabbit hearts: Effect on heart size and regional O2 supply/consumption variables (1988)
    Springer
    Basic research in cardiology 83 (1988), S. 268-276 
    Details
    ISSN: 1435-1803
    Keywords: propranolol ; cardiachypertrophy ; coronary blood flow ; myocardialoxygen consumption ; thyroxine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to determine the effect of acute and chronic propranolol on heart size and regional O2 supply/consumption variables in thyroxine (T4-treated rabbit hearts. New Zealand white rabbits were given 0.5 mg/kg T4 for 3 or 16 days with and without concomitant 2 mg/kg propranolol. Another group was given 16 days of propranolol alone and another 3-day T4 group was given 2 mg/kg propranolol 1 h before the experiment began. Another group served as control. Myocardial blood flows were determined using radioactive microspheres and small arteriolar and venous O2 saturations were determined using microspectrophotometry. Treatment with T4 for 3 or 16 days increased the heart weight/body weight ratio, myocardial blood flow, and regional O2 consumption. 16-day T4 treatment resulted in myocardial flow 195% and O2 consumption 300% above control group values. When propranolol was given chronically along with T4, heart weight/body weight ratios did not increase to the degree seen with 3 or 16 days of T4, alone. Propranolol given acutely in 3-day T4-treated animals, resulted in a reduced O2 consumption and O2 extraction, though not to the extent seen with chronic propranolol treatment of T4-treated animals. Acute propranolol treatment slightly reduced myocardial blood flow in 3-day T4-treated animals, while chronic treatment significantly reduced it. Chronic propranolol treatment in 16-day T4-treated animals resulted in a significant reduction in flow and O2 consumption. Thus, T4 treatment increased O2 consumption, flow, and heart size and these effects could be attenuated using acute and chronic propranolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907360
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  • 8
    Electronic Resource
    Electronic Resource
    The cardioprotective effects of the thromboxane receptor antagonist SQ 30,741 are not reversed by aspirin (1991)
    Springer
    Basic research in cardiology 86 (1991), S. 99-106 
    Details
    ISSN: 1435-1803
    Keywords: myocardial infarction ; thromboxane A2 ; aspirin ; coronary blood flow ; infarct size
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A previous study indicated that 5 mg/kg aspirin can reverse the cardioprotective effects of thromboxane A2 synthetase inhibitors. We determined in the present study if this dose of aspirin can also reverse the protective effects of the thromboxane A2/PGH2 receptor antagonist SQ 30,741 in the same model of coronary occlusion and reperfusion. Anesthetized dogs were subjected to 90 min of coronary occlusion and 5 h of reperfusion and were treated with vehicle or SQ 30,741 (1 mg/kg + 1 mg/kg/h) 10 min after the onset of coronary occlusion. SQ 30,741 was given to dogs pretreated with aspirin (5 mg/kg, 24 h presurgery) or vehicle. SQ 30,741 significantly reduced infarct size compared to vehicle treatment (58 % vs 35 % of the left ventricular area at risk for vehicle and SQ 30,741 groups respectively) and aspirin did not reverse this. These anti-ischemic effects occurred despite a lack of change in collateral flow. Thus, important differences in mechanism of action between thromboxane synthesis inhibitors and receptor antagonists seem to exist and further work in this area is warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02190542
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  • 9
    Electronic Resource
    Electronic Resource
    Linear viscoelastic behavior of copper phthalocyanine dispersions used in printing inks (1996)
    Springer
    Rheologica acta 35 (1996), S. 329-336 
    Details
    ISSN: 1435-1528
    Keywords: Copper phthalocyanine dispersions ; flocculation ; gelation threshold
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Abstract In this paper we describe the linear viscoelastic properties of copper phthalocyanine (CuPCN) dispersions that are used in the manufacturing of offset lithographic printing inks. Transmission electron microscopy shows that the primary pigment particles are rod-like and have sizes in the range of 10 to 300 nm. Steady shear measurements show that the dispersions are Newtonian at a pigment volume fraction of 0.073 and become increasingly shear thinning as the pigment volume fraction is increased. The strong shear-thinning nature of these dispersions can be attributed to the highly flocculated nature of the dispersions, which is due to interparticle attractions. The structural complexity of the dispersions also results in an unexpected linear viscoelastic response. While at low frequencies (0.1 and 1.0 Hz) the ex tent of the linear region decreases with increasing pigment concentration, at a higher frequency (10 Hz) the extent of the linear region increases with increasing pigment concentration. This increase in the linear region with increasing pigment concentration suggests that at higher frequencies the dispersion is less brittle, and that the rheological behavior is dominated by intra-aggregate associations. In addition, frequency sweeps show that the dispersions behave like a viscoelastic liquid at low pigment concentrations. However, at higher pigment concentrations (yet significantly lower than the maximum packing fraction) the dispersions behave like a cross-linking polymer at its gel point.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403533
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  • 10
    Electronic Resource
    Electronic Resource
    Seasonal variability in the responses of the domestic fowl,Gallus domesticus, to endotoxemia (1979)
    Springer
    Journal of comparative physiology 134 (1979), S. 287-292 
    Details
    ISSN: 1432-136X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The domestic fowl is reported to be extremely resistant toE. coli endotoxemia. We reported (Merrill et al., 1978) that in our hands this species displayed a lowlevel sensitivity similar to that seen in mammals. The discrepancy between previous reports and our recent findings could result from 1) seasonal differences in the responses of the domestic fowl to endotoxemia, 2) the age and nutritional status of animals used in these various studies, and/or 3) the toxicity of the different endotoxins used. Since there is a paucity of information regarding seasonal influences on the responses of experimental animals to shock and trauma, we have extended our earlier studies (conducted in October, fall group) to each of the remaining seasons of the year. Overnight, fasted, unanesthetized white Leghorn roosters (N=38) weighing 2.44±0.6 kg were injected intravenously with anE. coli endotoxin suspension (2.5 mg/kg). A separate group of birds (N=8) were injected with 0.9% saline. Plasma glucose, lactate, corticosterone, arterial blood gases and pH and selected hemodynamic variables were monitored for 24h or until death. Only four of eleven endotoxemic fall birds survived 24 h (LD64). All winter birds (N=9) survived the challenge (LDO), while seven of nine spring and summer-challenged animals (N=9 each group) survived for 24 h (LD22 both groups). The preterminal hypoglycemia and progressive lactacidemia seen in similarly-challenged mammals did not occur in any group. Plasma glucose levels in the fall group (least resistant) were significantly lower than in all other groups. The winter group (most resistant) showed the highest glucose levels. Elevation of plasma corticosterone following the endotoxin challenge was greatest in the winter group and least in the fall group. Similar corticosterone increases were seen in the spring and summer groups. We conclude that resistance to endotoxemia in the domestic fowl is influenced by the season of the year and that such seasonal influences are reflected, in part, by circulating levels of glucose and corticosterone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00709995
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