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  • 1
    Electronic Resource
    Electronic Resource
    Clinical and microbiological changes associated with the use of combined antimicrobial therapies to treat “refractory” periodontitis (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 31 (2004), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The present investigation examined clinical and microbial changes after a combined aggressive antimicrobial therapy in subjects identified as “refractory” to conventional periodontal therapy.Method: Fourteen subjects were identified as “refractory” based on full-mouth mean attachment loss and/or 〉3 sites with attachment loss 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE573:ges" location="ges.gif"/〉3 mm following scaling and root planing (SRP), periodontal surgery and systemic antibiotics. After baseline monitoring, subjects received SRP, locally delivered tetracycline at pockets 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE573:ges" location="ges.gif"/〉4 mm, systemically administered amoxicillin (500 mg, t.i.d. for 14 days)+metronidazole (250 mg, t.i.d. for 14 days) and professional removal of supragingival plaque weekly for 3 months. Subjects were monitored clinically every 3 months post-therapy for 2 years. Subgingival plaque samples were taken at the same time points from the mesial aspect of each tooth and the levels of 40 subgingival taxa were determined using checkerboard DNA–DNA hybridization. Mean levels of each species were averaged within a subject at each visit. Significance of changes in clinical and microbiological parameters over time were evaluated using the Friedman or Wilcoxon signed ranks test.Results: On average, subjects showed significant improvements in all clinical parameters after therapy. Mean (±SEM) full-mouth pocket depth reduction was 0.83±0.13 mm and mean attachment level “gain” was 0.44±0.12 at 24 months. Clinical improvement was accompanied by major reductions in multiple subgingival species during the first 3 months of active therapy that were maintained for most species to the last monitoring visit. Reductions occurred for three Actinomyces species, “orange complex” species including Campylobacter showae, Eubacterium nodatum, three Fusobacterium nucleatum subspecies, Peptostreptococcus micros, Prevotella intermedia as well as the “Streptococcus milleri” group, Streptococcus anginosus, Streptococcus constellatus and Streptococcus intermedus. Subjects differed in their response to therapy; six modest response subjects exhibited less attachment level gain and were characterized by reductions in the microbiota from baseline to 3 months, but re-growth of many species thereafter.Conclusions: The combined antibacterial therapy was successful in controlling disease progression in 14 “refractory” periodontitis subjects for 2 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.2004.00573.x
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  • 2
    Electronic Resource
    Electronic Resource
    Factors affecting androgen sex reversal of Tilapia aurea
    Amsterdam : Elsevier
    Aquaculture 25 (1981), S. 59-65 
    Details
    ISSN: 0044-8486
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0044-8486(81)90099-5
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  • 3
    Electronic Resource
    Electronic Resource
    Use of antithrombin III in critical patients (1994)
    Springer
    Intensive care medicine 20 (1994), S. 577-580 
    Details
    ISSN: 1432-1238
    Keywords: Antithrombin III ; Hemostasis ; Sepsis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To evaluate the effect of the AT III concentrates upon the clinical evolution and hemostatic parameters. Design Prospective, open, randomized trial. Patients and participants Septic and multiple trauma patients admitted to our Intensive Care Unit. Setting Levels of AT III below 70% were used as criteria to choose 36 patients, 20 of whom received treatment with AT III and 16 did not. Interventions AT III concentrates were administered at an initial dose of 60 U/kg followed by 10 U/kg every six hours. Results The administration of AT III neither contributes to alterations in haemostasis, nor the clinical evolution (evaluated according to Apache II score). Conclusions The results suggest that the administration of AT III concentrates to critical patients with acquired low levels, but without manifest DIC, may not be justified; although further studies on a larger population are required to establish definite conclussions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01705725
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  • 4
    Electronic Resource
    Electronic Resource
    Verbally administered Barthel Index as functional assessment in brain tumour patients (1997)
    Springer
    Journal of neuro-oncology 34 (1997), S. 187-192 
    Details
    ISSN: 1573-7373
    Keywords: glioma therapy ; neurological function ; activities of daily living ; Barthel Index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To investigate verbally administered Barthel Index asa measure of functional status in patients withhigh grade gliomas. Background: Barthel Index (BI) isa performance score of activities of daily livingwhich has been validated in patients with neurologicaldisability. While any assessment of quality of lifein brain tumour patients should include all theaspects of CNS function we concentrated on measurementof physical performance status and evaluated the roleof BI as a measure of palliative effectof treatment in patients with high grade gliomaundergoing radiotherapy. Methods: BI was verbally administered on504 occasions in 107 patients with high gradeglioma. The BI scores were correlated with Karnofskyperformance score (KPS), and neurological performance score (NPS)as a measure of inter-index reliability. The BI'sprognostic value was assessed using actuarial survival data.Results: BI was sensitive to change and reflectedthe degree of functional impairment. In patients withhigh grade glioma BI correlated with KPS, andNPS (R2=0.872 and 0.658 respectively). BIscore was also of prognostic value in termsof survival. The median survival of patients withfunctional independence was 9 months with moderate disability5 months and with severe disability 4 months.Conclusion: Verbally administered Barthel Index is easy touse, reliable and sensitive to change and isof prognostic value. It is a useful toolin the management of patients with gliomas, asan objective evaluation of palliative effectiveness of treatmentin patients with functional disability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005710729748
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  • 5
    Electronic Resource
    Electronic Resource
    A mechanistic study of the formation of polymer nanoparticles by the emulsification-diffusion technique (1997)
    Springer
    Colloid & polymer science 275 (1997), S. 640-647 
    Details
    ISSN: 1435-1536
    Keywords: Key words Polymer ; nanoparticles ; emulsification ; diffusion method ; spontaneous emulsification ; interfacial turbulence ; diffusion stranding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  The mechanism of formation of polymer nanoparticles prepared by the emulsification–diffusion method was evaluated under different preparation conditions and by turbidimetry measurements. Biodegradable poly (D,L-lactic acid) was used as the polymer model. The results show that each emulsion droplet will form several nano-particles and that the interfacial phenomena during solvent diffusion determine the size properties of the resulting colloid particles. These phenomena cannot be entirely explained by the convection effects caused by interfacial turbulence. We suggest that nanoparticle formation is due to diffusion alone, and we propose a mechanism based on the “diffusion-stranding” mechanism for spontaneous emulsification. In this mechanism, the diffusion of solvent causes local supersaturation near the interface, and nanoparticles are formed, due to the phase transformation and polymer aggregation that occur in these regions. This interpretation is supported by the turbidity measurements made at different polymer concentrations and stirring rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050130
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    Paper (German National Licenses)
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