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Use of TRH Analogues in Motorneurone Disease (1989)

GUILOFF, R. J.

Oxford, UK : Blackwell Publishing Ltd

Annals of the New York Academy of Sciences 553 (1989), S. 0

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ISSN: 1749-6632

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Natural Sciences in General

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1749-6632.1989.tb54508.x

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Axonal atrophy in the painful peripheral neuropathy in AIDS (1990)

Fuller, G. N. ; Jacobs, J. M. ; Guiloff, R. J.

Springer

Acta neuropathologica 81 (1990), S. 198-203

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ISSN: 1432-0533

Keywords: AIDS ; Pain ; Neuropathy ; Axonal atrophy

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary We compared the sural nerves from patients with AIDS; four with the painful peripheral neuropathy (PPN), three patients with non-painful distal symmetrical peripheral neuropathy (DSPN), one without clinical peripheral nerve involvement and two human immunodeficiency virus negative controls. Fibre diameter distributions showed a slight reduction in larger fibres in all patients with AIDS compared with controls. No significant difference was found in the relative frequency distribution of the lamellae counts between any of the groups. The relative frequency distribution of axonal area of myelinated fibres did not differ between controls, non-pailful DSPN or the patient without peripheral nerve involvement; however, all patients with PPN showed marked reduction in the number of axons of myelinated fibres of larger area which was significant when compared to each patient from the other groups (P〈0.0001). This indicates that the reduction in larger fibres in PPN is mostly due to axonal atrophy rather than selective fibre loss. Axonal atrophy is associated with painful peripheral neuropathy in AIDS but not with those without pain. The possible role of axonal atrophy as a pathological substrate for pain is discussed.