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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 224 (1969), S. 360-361 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The palaeomagnetic method can provide a geologically precise estimate of the time span of a section of lavas, when a coincidence of lava extrusion and geomagnetic polarity change occurs. Cox and Dalrymple have shown that 4,600 yr (with 95 per cent confidence limits at 1,200 and 21,000 yr)1 is the ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    The @Journal of Behavioral Economics 16 (1987), S. 13-22 
    ISSN: 0090-5720
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Sensors and Actuators 17 (1989), S. 81-88 
    ISSN: 0250-6874
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two monoclonal antibodies against ricin toxin A chain (RTA) have been examined for their effects on the blood survival and biodistribution of RTA and recombinant ricin A chain in mice. When admixed with the toxins at 1:1 molar ratios prior to intravenous injection, the antibodies prolonged blood survival and whole-body retention of both species of RTA, and this was due essentially to reduced renal clearance of the toxins. Immune complexes were identified by gel filtration chromatography and immune precipitation with anti-IgG antiserum in mixtures prior to injection and in the serum of mice injected with the mixtures. An irrelevant monoclonal antibody showed no complex formation, and no effect on biodistribution. These studies have shown that immune complexes formed between monoclonal antibodies and protein antigens of molecular mass up to at least 30 kDa survive in the circulation, rather than being cleared by the reticuloendothelial system. Such antibodies could be used to modulate the biodistribution of toxic molecules such as ribosome-inhibiting proteins like RTA. This might be exploited therapeutically, for example in the construction of bispecific antibodies against ribosomal inhibiting proteins and tumour-associated antigens.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 65 (1976), S. 1078-1108 
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract Petrographic and geochemical study of 79 samples from the Limestone Caribbee islands of Antigua, St. Martin and Desirade show different degrees of metasomatic alteration resulting from burial metamorphism up to lower zeolite facies (with laumontite and prehnite). In Antigua, Oligocene unaltered plagioclase basalt, andesite and dacite, identical to the low-K island-arc lavas of nearby Guadeloupe, occur with their partly and greatly altered equivalents. Most thoroughly altered are the flows, dykes and trondhjemite intrusion of Desirade island (in part Jurassic). Two types of alteration are closely associated in these islands. Spilitisation leading to albitisation of plagioclase, chloritisation of orthopyroxene and the formation of calcite, zeolite, i prehnite, ± epidote, ± native copper results in enrichment in Na2O (to 8.8 %) and depletion in K2O, CaO, Rb, Sr, Ba and Cu. Less common is poeneitisation, which resembles spilitisation but also involves sericitisation and partial replacement of plagioclase by alkali feldspar, in turn resulting in enrichment in K2O (to 9.4 %), Ba and often Na2O, Rb and Sr. Clinopyroxene and quartz are unchanged by the alteration. Comparison of the altered rocks with lavas from different tectonic environments reveals that metasomatism leads to nonmagmatic bulk compositions. The unaltered and least altered lavas are island arc type while the Ni content (which appears unaffected by metasomatism) indicates that the spilitic pillow lavas of E. Desirade are Ni-rich ocean floor basalts.
    Abstract: Résumé L'étude pétrographique et géochimique de 79 échantillons provenant des Iles calcaires des Caraïbes, Antigua, St. Martin et la Désirade, montre une forte transformation métasomatique différentielle des roches à la suite d'un métamorphisme d'enfouissement. Celui-ci va jusqu'au facies inférieur zéolithique (avec laumontite et prehnite). Dans Antigua, on trouve indemnes de toute transformation, des basaltes à plagioclase, des andésites et dacites d'âge oligocène. Ces laves sont identiques avec les laves des arcs insulaires à faible teneur en K de la Guadeloupe voisine. A côté de ces laves intactes, on trouve également des équivalents partiellement ou fortement transformés. Comme profondément modifiés, on trouve des coulées, filons et intrusions de trondhjémite de la Désirade (roches en partie également jurassiques). Deux modes de transformation sont itimement associés dans ces îles. La spilitisation du a conduit a l'albitisation du plagioclase, la chloritisation de l'orthopyroxène et à la formation de calcite, zéolite, ± prehnite, ± épidote, ± cuivre natif. Elle a aussi conduit à un enrichissement des roches en Na2O (jusque 8,8 %) et un appauvrissement en K, Ca, Rb, Sr, Ba et Ca. Plus rarement une une poeneitisation est observée; celle-ci ressemble à la spilitisation mais conduit à la séricitisation et en partie à une substitution partielle du plagioclase en feldspath alcalin, ce qui conduit à nouveau à un enrichissement en K2O (jusque 9,4 %), Ba et souvent Na2O, Rb et Sr. Le clinopyroxène et le quartz ne sont pas transformés au cours de cette modification. Une comparaison des roches transformées avec les laves de différentes régions tectoniques montre que la métasomatose a conduit à un chimisme non magmatique. Les laves pas ou seulement peu modifiées appartiennent au type des arcs insulaires, tandis que la teneur en Ni (qui n'est pas influencée par les processus métasomatiques) montre que les laves en coussins spilitiques de l'E de la Désirade, sont des laves basaltiques de fond océanique riches en Ni.
    Notes: Zusammenfassung Die petrographische und geochemische Untersuchung von 79 Proben von den Kalkstein-Karibeninseln Atigua, St. Martin und Desirade zeigt eine unterschiedlich starke metasomatische Veränderung der Gesteine infolge einer Versenkungsmetamorphose. Diese reichte bis hinauf zur unteren Zeolitfazies (mit Laumontit und Prehnit). In Antigua treten unveränderte oligozäne Plagioklasbasalte, Andesite und Dacite auf. Diese Laven sind identisch mit den low-K Inselbogenlaven des nahegelegenen Guadeloupe. Neben diesen unveränderten Laven treten auch teilweise oder erheblich veränderte Äquivalente auf. Sehr weitgehend verändert sind die Ergüsse, Gänge und die Trondheimit-Intrusion von Desirade (diese Gesteine sind zum Teil jurassisch). Zwei Arten von Veränderung sind in diesen Inseln eng miteinander verbunden. Die Spilitisierung von Plagioklas führte zur Albitisierung von Plagioklas, zur Chloritisierung von Orthopyroxen und zur Bildung von Calcit, Zeolit, ± Prehnit, ± Epidot, ± Rohkupfer. Sie führte somit zu einer Anreicherung der Gesteine an Na2O (bis 8,8%) und einer Verarmung an K2O, CaO, Rb, Sr, Ba und Cu. Seltener ist eine Poeneitisierung zu beobachten; diese ähnelt der Spilitisierung, führt aber auch zu einer Serizitisierung und zu teilweisem Austausch von Plagioklas gegen Alkalifeldspat, was wiederum zu einer Anreicherung von K2O (auf 9,4 %), Ba und oft N2O, Rb und Sr führt. Clinopyroxen und Quarz werden durch diese Umwandlung nicht verändert. Ein Vergleich der umgewandelten Gesteine mit Laven von verschiedenen tektonischen Bereichen zeigt, daß Metasomatismus zu nicht-magmatischem Chemismus führt. Die nicht oder nur wenig umgewandelten Laven gehören zum Inselbogentyp, während der Ni-Gehalt (der unbeeinflußt von metasomatischen Vorgängen ist) zeigt, daß die spilitischen Pillowlaven von Ost-Desirade Ni-reiche Ocean-floor-Basalte sind.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-069X
    Keywords: Key words Contact hypersensitivity ; Poison ivy/oak ; Urushiol ; Monoclonal antibody ; Immunotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of the studies was to demonstrate that the contact sensitivity (CS) response to poison ivy/oak could be downregulated following treatment with a monoclonal antibody (mAb) reacting with the allergen urushiol. Conjugation of urushiol and its synthetic analogue 3-n-pentadecylcatechol (PDC) to ¶N-acetylcysteine yielded hydrosoluble derivatives which induced humoral immune responses in BALB/c mice. Hybridomas secreting monoclonal antibodies (mAbs) reacting with urushiol and PDC were generated by fusion of B lymphocytes from immunized mice with mouse myeloma P3NS0 cells. The specificity of mAb ALG 991 (IgM isotype) was defined by inhibition of antibody binding by PDC analogues. This demonstrated that mAb ALG 991 reacted with the catechol moiety of urushiol, the region of the allergen being critically important in the induction of contact dermatitis. The CS response to urushiol in BALB/c mice was suppressed by stimulation with mAb ALG 991 and the role of sensitized T cells, including suppressor T cells, has been considered. Suppression of CS was most effective with low doses (1 μg) of mAb incorporated into a vaccine with Freund’s adjuvant. This treatment suppressed CS responses in BALB/c mice already sensitized to urushiol.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Oecologia 81 (1989), S. 428-429 
    ISSN: 1432-1939
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 32 (1971), S. 79-92 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Twelve lavas have been sampled on Amsterdam Island, which is an extinct shield volcano located on a transform fault crossing the south-eastern branch of the Indian Ocean rise. Chemical analyses show that the lavas have mainly tholeiitic affinities, ranging from olivine tholeiites to plagioclase basalts with accumulation of bytownite. The high alumina lavas are similar to bytownite cumulates dredged from the Indian Ocean rise, and the low alumina lavas resemble tholeiites of Hawaii. The volcano appears to be in an early stage of evolution from oceanic ridge basalt to an alkaline volcano.
    Type of Medium: Electronic Resource
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