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  • 1
    Electronic Resource
    Electronic Resource
    Influence of pantoprazole on oesophageal motility, and bile and acid reflux in patients with oesophagitis (2001)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Reflux of duodeno-gastric juice into the oesophagus appears to be involved in the pathogenesis of both reflux oesophagitis and oesophageal adenocarcinoma. Although proton pump inhibitors have been shown to decrease acid reflux and heal oesophagitis, their effect on biliary reflux and motility is less clear.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To investigate whether pantoprazole also reduces bile reflux and whether this is paralleled by a change in oesophageal motility.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Combined 24-h measurements of intraoesophageal bilirubin concentration, pH and pressure were performed in 18 symptomatic patients with endoscopically proven reflux oesophagitis before and on day 28 of treatment with pantoprazole, 40 mg/day, under standardized conditions. A reflux symptom score was determined initially and every 2 weeks thereafter. After 56 days on medication, a control endoscopy was performed.〈section xml:id="abs1-4"〉〈title type="main"〉Results:The symptom score and the acid and bile reflux improved significantly, whereas the motility parameters did not change during the study period. Helicobacter pylori-positive patients had a significantly higher bile reflux time (32.1 ± 4.3%) than H. pylori-negative patients (16.3 ± 3.1%) (P=0.009). The endoscopic healing rate was 89%. The cough symptoms disappeared in three of four patients.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:The proton pump inhibitor pantoprazole decreases both acid and bile reflux. The decrease of bile reflux cannot be explained by increased oesophageal clearance as oesophageal motility did not improve with therapy. Interestingly, H. pylori infection of the stomach was associated with higher levels of oesophageal bile reflux.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2001.01069.x
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  • 2
    Electronic Resource
    Electronic Resource
    A probabilistic approach for evaluating a technique for an indirect monitoring of the capillary blood flow to the gastric parietal cells
    Amsterdam : Elsevier
    Bulletin of Mathematical Biology 49 (1987), S. 171-185 
    Details
    ISSN: 0092-8240
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0092-8240(87)80041-1
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  • 3
    Electronic Resource
    Electronic Resource
    A probabilistic approach for evaluating a technique for an indirect monitoring of the capillary blood flow to the gastric parietal cells
    Amsterdam : Elsevier
    Bulletin of Mathematical Biology 49 (1987), S. 171-185 
    Details
    ISSN: 0092-8240
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0092-8240(87)80041-1
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  • 4
    Electronic Resource
    Electronic Resource
    Heightened free radical activity in blacks with chronic pancreatitis at Johannesburg, South Africa
    Amsterdam : Elsevier
    Clinica Chimica Acta 230 (1994), S. 189-199 
    Details
    ISSN: 0009-8981
    Keywords: Chronic pancreatitis ; Free radical oxidation prod ucts ; Free radicals ; Glutathione ; Oxidative stress ; Vitamin C
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(94)90271-2
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  • 5
    Electronic Resource
    Electronic Resource
    Savoxepine: striatal dopamine-D2 receptor occupancy in human volunteers measured using positron emission tomography (PET) (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 135-140 
    Details
    ISSN: 1432-1041
    Keywords: Savoxepine ; Neuroleptic drug ; dopamine D2 receptor antagonist ; positron emission tomography ; striatal receptor binding ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The extent and duration of striatal dopamine-D2 receptor occupancy by savoxepine in humans has been studied using positron emission tomography with [11C]-raclopride, in order to investigate why the anticipated favourable ratio between its extrapyramidal and antipsychotic effects was not achieved in practice. After 0.25 mg savoxepine, striatal D2 receptor occupancy peaked at 50–60% after 24–36 h and disappeared within 6 days. After doses of 0.1 mg to 0.5 mg, D2 receptor occupancy in the putamen and caudate nucleus increased from 20 to 70% 3–7 h after administration and amounted to 40 to 75% at the peak time (20–29 h). This suggests that cumulative D2 receptor blockade would occur if equal or increasing doses of savoxepine were given repeatedly. Extrapyramidal adverse-effects would be likely to occur under such circumstances. An adequate test of the theory that preference for hippocampal dopamine D2 receptors with afford a good therapeutic ratio requires an alternative dosing regimen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315470
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  • 6
    Electronic Resource
    Electronic Resource
    Autopsy: quality assurance in the ICU (1999)
    Springer
    Intensive care medicine 25 (1999), S. 360-363 
    Details
    ISSN: 1432-1238
    Keywords: Key words Critical care unit ; Autopsy diagnosis ; Quality assurance ; Class I error ; Class II error
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To examine the correlation between the clinical diagnosis and autopsy findings in adult patients who died in an intensive care unit (ICU). To determine the rate of agreement of the basic and terminal causes of death and the types of errors in order to improve quality control of future care. Design: Retrospective study. Setting: Adult ICU in a university hospital. Patients: 30 adult patients who died in the ICU, with the exclusion of medicolegal cases. Methods and main results: Anatomo-clinical meetings were held to analyze the pre- and postmortem correlations in 30 consecutive autopsies at the ICU of the University Hospital, School of Medicine of Botucatu/ UNESP, from January 1994 to January 1997. The rate of correct clinical diagnoses of the basic cause was 66.7 %; in 23.3 % of cases, if the correct diagnosis was made, management would have been different, as would have been the evolution of the patient's course (Class I error); in 10 % of the cases the error would not have led to a change in management (Class II error). The rate of correct clinical diagnoses of terminal cause was 80 %. Conclusions: The rate of recognition of the basic cause was 66.7 %, which is consistent with the literature, but the Class I error rate was higher than that reported in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050858
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  • 7
    Electronic Resource
    Electronic Resource
    Complete convergence for arrays (1992)
    Springer
    Periodica mathematica Hungarica 25 (1992), S. 51-75 
    Details
    ISSN: 1588-2829
    Keywords: 1991 ; Primary 60F15 ; 60G50 ; Key words and phrases ; Array ; rowwise independence ; sums of independent random variables ; complete convergence ; strong law ; central limit theorem ; weighted sums
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Let {(X nk , 1≤k≤n),n≥1}, be an array of rowwise independent random variables. We extend and generalize some recent results due to Hu, Móricz and Taylor concerning complete convergence, in the sense of Hsu and Robbins, of the sequence of rowwise arithmetic means.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02454383
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  • 8
    Electronic Resource
    Electronic Resource
    A new membrane tube technique (METT) for continuous gas measurements in soils (1998)
    Springer
    Plant and soil 198 (1998), S. 79-88 
    Details
    ISSN: 1573-5036
    Keywords: membrane tube ; nitric oxide ; radon-222 ; sampling technique ; soil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract We present a novel technique for monitoring trace gas concentrations in the air filled pore space of the soil with a high temporal resolution. The method is based on gas diffusing from the air filled pore space into air flowing through an air permeable, hydrophobic, polypropylene tube (Accurel® PP V8/2). Gas permeation efficiencies of the membrane tube were determined for NO, N2O, CO2 and 222Rn in the laboratory. For a length of 1.5 m and flows smaller than 0.8 L min-1, the permeation efficiency was larger than 96%. The effective diffusion coefficients of NO, N2O, CO2 and 222Rn in the membrane are 6.2, 6.6, 5.6 and 6.6 times smaller than the corresponding diffusion coefficients in air, respectively. For tubes shorter than 1.5 m the contribution of pressure gradient induced transport into the membrane tube is below 0.9% of concentration gradient induced transport. Profiles of NO and 222Rn have been measured in the soil of a wheat field. For destructive NO measurements the inlet concentration of the tube was adjusted to the concentrations measured at the outlet whereas for the non-destructive 222Rn measurements the sampled gas was recycled.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004277519234
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  • 9
    Electronic Resource
    Electronic Resource
    Nitric oxide flux from soil during the growing season of wheat by continuous measurements of the NO soil–atmosphere concentration gradient: A process study (1999)
    Springer
    Plant and soil 216 (1999), S. 165-180 
    Details
    ISSN: 1573-5036
    Keywords: agriculture ; fertilisation ; nitric oxide flux ; nitrification ; wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The surface flux of nitric oxide from a wheat field was investigated from 23 March to 29 May 1997 in the Kerzersmoos, Switzerland. A plot fertilised with 19 kg N ha-1 in cattle slurry and 40 kg N ha-1 in mineral NH4NO3 fertiliser and a plot receiving no nitrogen containing fertiliser were compared. The flux was calculated based on hourly measurements of the NO soil–atmosphere concentration gradient using the one-dimensional soil diffusion model of Galbally and Johansson (1989). The soil bulk diffusion coefficient was determined from measurements of the 222Rn surface flux and the activity gradient between 10 cm depth and the surface. It ranged between 79% and 0.3% of the NO diffusion coefficient in air and was parameterised by air filled soil pore space. The indirectly determined NO flux agreed well with standard flux measurements using dynamic chambers. The largest NO emission was found following fertiliser application and irrigation. The emission occurred in pulses, which lasted for 4 days up to 3 weeks coinciding with elevated soil ammonium concentrations. Nitric oxide emission in 5 days following application of cattle slurry were 31 g NO-N ha-1 and 5 g NO-N ha-1 from the non-fertilised plot, respectively. Nitric oxide emission in 15 days following application of NH4NO3 was 95 g NO-N ha-1 and 10 g NO-N ha-1 from the non-fertilised plot, respectively. NO emission in 4 days following irrigation on 21 April were 36 g N ha-1 from the fertilised and 39 g N ha-1 from the non-fertilised plot. The daily NO emission before and after fertiliser and irrigation pulses was between 0.3 and 0.7 g NO-N ha-1 d-1. NO production and NO uptake of the soil was measured regularly. No systematic influence of management or climate on NO uptake was found. NO production was strongly stimulated by fertiliser input and soil moisture content. The simulation of NO production could be reproduced using a nitrification algorithm (Riedo et al., 1998) driven by soil temperature, moisture and ammonium concentration. A NO production rate constant of 1.1ċ10-3 h-1 at 15 °C was derived from a linear regression between nitrification and NO production. Introducing the parameterisation of NO production into the model of Galbally and Johansson (1989) the duration and the strength of the NO emission pulses could be reproduced and the total NO emission during the experiment was approximated within a factor of two.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004752104808
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  • 10
    Electronic Resource
    Electronic Resource
    Complete convergence and convergence rates for randomly indexed partial sums with an application to some first passage times (1983)
    Springer
    Acta mathematica hungarica 42 (1983), S. 225-232 
    Details
    ISSN: 1588-2632
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01956770
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