Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 35 (1957), S. 1058-1067 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1335
    Keywords: Thyroid carcinoma ; Lymphocytic infiltration ; CD68 ; Angiogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunohistochemical detection and quantification of CD3-and CD45RO-positive lymphocytes and CD68-positive cells in 75 thyroid carcinomas of follicular cell origin revealed rising levels for these parameters associated with dedifferentiation. A parallel trend towards reduction of vascularisation, determined as CD31-positive blood vessels, with decreasing differentiation became evident, statistically only significant when well-differentiated follicular and anaplastic carcinomas were compared. Positive correlations could be demonstrated between the density of CD68-, CD3-, and CD45RO-positive cells as well as between the density of CD68-, and CD3-, and CD45RO-positive cells and vascularisation. These correlations were expected, as the interaction of CD68-positive cells and T lymphocytes results in the production of angiogenesis factors, ultimately leading to better vascularisation of the tumour. Nevertheless, the tumour cells themselves are variously capable of producing angiogenic substances. The obvious lack of positive correlation between the density of tumour-infiltrating cells determined in this study and vascularisation, despite reduced vascularisation in less differentiated tumours that contained increasing numbers of tumour-infiltrating cells, seems to be due to functional heterogeneity of morphologically similar, tumours.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1619-7089
    Keywords: Cardiac transplantation ; Sympathetic re-innervation ; Iodine-123 metaiodobenzylguanidine ; Thallium-201 ; Dual-isotope technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cardiac transplantation entails surgical disruption of the sympathetic nerve fibres from their somata, resulting in sympathetic denervation. In order to investigate the occurrence of sympathetic re-dnnervation, neurotransmitter scintigraphy using the norepinephrine analogue iodine-123 metaiodobenzylguanidine (MIBG) was performed in 15 patients 2–69 months after transplantation. In addition, norepinephrine content and immunohistochemical reactions of antibodies to Schwarm cell-associated S100 protein, to neuron-specific enolase (NSE) and to norepinephrine were examined in 34 endomyocardial biopsies of 29 patients 1–88 months after transplantation. Anterobasal123I-MIBG uptake indicating partial sympathetic re-dnnervation could be shown in 40% of the scintigraphically investigated patients 37–69 months after transplantation. In immunohistochemical studies 83% of the patients investigated 1–72 months after transplantation showed nerve fibres in their biopsies but not positive reaction to norepinephrine. Significant norepinephrine content indicating re-dnnervation could not be detected in any biopsy. It was concluded that in spite of the lack of norepinephrine content there seemed to be immunohistological and scintigraphic evidence of sympathetic re-dnnervation. An explanation for this contradictory finding may be the reduced or missing norepinephrine storage ability compared to the restored uptake ability of regenerated sympathetic nerve fibres.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1573-7217
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1573-7217
    Keywords: breast cancer ; classification schemes ; measure of separation ; node negative ; recurrence-free survival ; validation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several prognostic classification schemes in node negative breastcancer are proposed, but only the Nottingham PrognosticIndex (NPI) seems to be sufficiently validated. Validation,which is a prerequisite for a sensible assessment,is not published for two recent proposals accordingto Glick et al. [1] and Rubens [2].The German Breast Cancer Study Group (GBSG) entered662 eligible patients in a prospective observational study.603 of them had complete data for seven’standard‘ prognostic factors and median follow-up is about5 years. As there is no accepted andinformative measure of separation for classification schemes presentlyavailable, we propose a new one and useit additionally to the well known logrank-test andKaplan-Meier estimates to investigate the predictive power ofthe three schemes. Significant differences in survival andrecurrence-free survival could be established for the NPIsubgroups but not for others where even theordering of the groups was different. With theCox model and the classification and regression treeapproach we develop two new proposals for thedifferentiation of subgroups of node negative patients. Asin the NPI, tumor size and grade arethe most important factors, but with a differentweighting scheme. Young age (≤ 40 years) andvery high estrogen receptor values (〉 300 fmol)in a small subgroup of patients were associatedwith worse prognosis. The new proposals showed abetter degree of separation, which demonstrates that animprovement seems possible using standard factors. Because themeasures of separation give an overoptimistic impression forthe new proposals, a validation with other studiesis necessary before a general recommendation can begiven.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 95 (1962), S. 926-936 
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Addition mehrerer Enamine an verschieden substituierte Isocyanate und Isothiocyanate wird beschrieben. Die erhaltenen Addukte lassen sich glatt zu β-Carbonyl-(thio)carbonsäure-amiden hydrolysieren.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 95 (1962), S. 937-943 
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Addukte aus Enaminen und Isothiocyanaten sowie deren Hydrolyseprodukte, die β-Carbonyl-thiocarbonsäureamide sind vorzügliche Ausgangsstoffe für den Aufbau von Heterocyclen. Es lassen sich damit substituierte Aminogruppen in sonst schwer zugängliche Stellungen einführen, wie Beispiele aus der Pyrazol- und Pyrimidinreihe zeigen.  -  In einem Ausnahmefall entsteht an Stelle des Adduktes I ein Derivat des bisher unbekannten 3-Aza-thiopyrons-(4).
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 94 (1961), S. 486-490 
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1-Morpholino-cyclohexen-(1) und -cyclopenten-(1) reagieren mit Diketen zu 2-Methyl-5.6.7.8-tetrahydro-chromon (IV) bzw. 2-Methyl-5.6-trimethylen-pyron-(4) (X), deren Konstitution bewiesen wird.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Particle and Particle Systems Characterization 10 (1993), S. 138-145 
    ISSN: 0934-0866
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Essentially the laser two-focus (L2F) and laser Doppler anemometer (LDA) are time-of-flight anemometers. The velocity of particles in the micrometre range is determined within the limits of an optically fixed measurement distance. For this only one optoelectronic receiver for the detection of the scattered light is required [1, 2]. With an arrangement of two receiving optics, positioned under an off-axis angle ϕ and an elevation angle ± ψ to the optical axis of the measurement system, a resolution of three-dimensional structures can be achieved and with regard to spherical particles it is possible to determine the dimensions by means of the temporal or phase shift of the signals in the receiving optics. A particle size-dependent distance inside the measurement volume can be fixed, which has to be passed in order to change the signal from one receiving optics to the other. An LDA with an arrangement of two receiving optics for particle sizing is known as a phase Doppler anemometer (PDA); an L2F designed with two receiving optics can be termed a pulse-displacement two-focus anemometer (P2F). The physical analysis of the two methods with respect to a temporal signal displacement in the receivers yielded new results.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...