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  • 1
    Electronic Resource
    Electronic Resource
    A case of sjögren's syndrome with severe anemia due to myelitis (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 92-95 
    Details
    ISSN: 1432-1440
    Keywords: Sjögren's syndrome ; Anemia ; Vasculitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An unusual case of Sjögren's syndrome presenting with severe anemia as the predominant clinical feature is described. Histological examination of a bone marrow biopsy specimen demonstrated that the patient's anemia was caused by myelitis and vasculitis of the small intraosseous vessels. Our report might stimulate a more thorough investigation of bone marrow in patients with connective tissue diseases and anemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784137
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differentiation of human lymphocytes by pokeweed mitogen in vitro: Studies in normal and in immunodeficient subjects (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 743-749 
    Details
    ISSN: 1432-1440
    Keywords: Immunglobulinsynthese ; Pflanzenlektine ; Primäre Immunmangelsyndrome ; Suppressor Lymphozyten ; Immunoglobulin synthesis ; Plant lectins ; Primary immunodeficiencies ; Suppressor lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Immunoglobulin (Ig) synthesis and secretion by peripheral blood lymphocytes activated by pokeweed mitogen (PWM), and by phytohemagglutinin (PHA) was measured in normal individuals and in subjects with primary immunodeficiency. Unstimulated cultures demonstrated stable, low Ig synthesis of all major Ig classes; PWM showed a peak of Ig synthesis at day 5; PHA cultures demonstrated a late peak of Ig production at day 9. Three cases of common variable immunodeficiency showed different patterns of data when the percentage of B cells in blood and Ig production in vitro were used as parameters. Two persons with immunodeficiency and thymoma showed decreased Ig production in vitro, and had suppressor cells capable of blocking Ig production by normal lymphocytes in co-cultivation experiments.
    Notes: Zusammenfassung Immunglobulinsynthese und Sekretion der Lymphozyten von Normalpersonen und Patienten mit primären Immundefekten wurde nach Stimulierung mit Pokeweed Mitogen oder Phytohaemagglutinin gemessen. Unstimulierte Kulturen zeigten eine stabile, geringe Immunglobulinsynthese aller drei Immunglobulinklassen. Immunglobulinsynthese in Pokeweed Mitogen stimulierten Kulturen zeigte einen Gipfel an Tag 5, phytohaemagglutinin-stimulierte Kulturen zeigten einen Gipfel an Tag 9. Drei Fälle von variablem Immunmangelsyndrom zeigten unterschiedliche Muster, wenn der Prozentsatz von B Lymphozyten und die in vitro Immunglobulinsynthese als Parameter herangezogen wurden. Zwei Patienten mit Immunmangelsyndrom bei Thymom zeigten verminderte Immunglobulinsynthese in vitro und hatten Suppressorzellen, die in Kokultivierungsexperimenten die Immunglobulinsynthese von Normallymphozyten blockierten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476961
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Detection of circulating immune complexes with a modified raji cell technique (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 899-901 
    Details
    ISSN: 1432-1440
    Keywords: Immunkomplexe ; Immune complexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A modification of the Raji cell technique for the detection of circulating immune complexes is described. Raji lymphoid cells bind immune complexes via the C 3 receptor. Prior to incubation with the test serum it is necessary to block the IgG Fc receptor which would interfere with the assay. In the present modification the IgG Fc receptor is blocked with monoclonal IgG myeloma proteins thereby facilitating the detection of C 3 bound immune complexes with fluorescein-conjugated anti-light chain serum. This modification is presently used in a survey of immune complexes in a number of autoimmune diseases.
    Notes: Zusammenfassung Eine Modifikation der Raji-Zell-Technik zum Nachweis zirkulierender Immunkomplexe wird beschrieben. Lymphoide Raji Zellen binden Immunkomplexe durch einen C 3 Rezeptor. Vor Inkubation mit dem Testserum ist es erforderlich, den IgG Fc Rezeptor zu blockieren, der andernfalls mit dem Immunkomplexnachweis interferieren würde. In der hier beschriebenen Methode wird der IgG Fc Rezeptor mit isoliertem IgG Myelomprotein blockiert mit Nachweis von C 3 Rezeptor gebundenen Immunkomplexen mit Fluoreszein-konjugierten Anti-Leichtkettenseren. Diese Modifikation wird gegenwärtig in größeren Kollektiven von Patienten mit verschiedenen Autoimmunerkrankungen benutzt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478825
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Antigenic relationship between Chang liver cells and human hepatocytes (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 525-527 
    Details
    ISSN: 1432-1440
    Keywords: Leberspezifisches Protein ; Hepatozyten ; Liver specific protein ; Hepatocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Using monospecific antisera against human liver specific protein (LSP) it could be demonstrated that Chang liver cells bear LSP on their membranes. Chang liver cells can therefore be used as in vitro system to study immune reactions against LSP in human inflammatory liver diseases.
    Notes: Zusammenfassung Mit Hilfe monospezifischer Antiseren gegen menschliches lebermembranspezifisches Protein (LSP) konnte gezeigt werden, daß Chang Leberzellen LSP auf der Zellmembran besitzen. Chang Leberzellen können daher als in vitro System zur Untersuchung immunologischer Reaktionen gegen LSP in menschlichen entzündlichen Lebererkrankungen benutzt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01492866
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The role of liver membrane antigens as targets in autoimmune type liver disease (1980)
    Springer
    Springer seminars in immunopathology 3 (1980), S. 297-315 
    Details
    ISSN: 1432-2196
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02054106
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    Paper (German National Licenses)
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