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  • 1
    Electronic Resource
    Electronic Resource
    Reduction of lecithin-cholesterol acyltransferase, apolipoprotein D and the Lp(a) lipoprotein with the anabolic steroid stanozolol
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 795 (1984), S. 293-296 
    Details
    ISSN: 0005-2760
    Keywords: Anabolic steroid ; Apolipoprotein B ; Apolipoprotein D ; Lecithin-cholesterol acyltransferase ; Lp(a) particle ; Stanozoloi
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2760(84)90078-X
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  • 2
    Electronic Resource
    Electronic Resource
    Strong impact of the electron-photon matrix element on angle-resolved photoelectron spectra of Sr 2 CuO 2 Cl 2 (2001)
    Springer
    The European physical journal 23 (2001), S. 69-77 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 74.72.Jt Other cuprates – 79.60.-i Photoemission and photoelectron spectra – 74.25.Jb Electronic structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: In recent years insight has been gained into the electronic structure of layered cuprates using angle-resolved photoelectron spectroscopy. In many of these studies it is assumed that the electron-photon matrix element follows the trends set by the atomic photoionization cross sections and does not influence lineshape, dispersion and the k-dependence of the spectral intensity. In this study using Sr2CuO2Cl2 as an example it will be shown that the electron-photon matrix element can have a strong impact on both strength and shape of a feature in an angle-resolved photoelectron spectrum of a layered cuprate which can strongly affect information on character and the momentum-dependence of the energy and spectral weight of a state deduced from the spectra. The results of this study put an emphasis on the need to employ the whole parameter range of the ARPES method to get reliable information on the spectral function of cuprates for which purpose synchrotron radiation is an uniquely suited tool.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100510170083
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  • 3
    Electronic Resource
    Electronic Resource
    Optical investigation of the quasi two-dimensional monophosphate tungsten bronzes K x P 4 W 8 O 32 (x = 0 - 1.57) (2001)
    Springer
    The European physical journal 24 (2001), S. 167-175 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 71.45.Lr Charge-density-wave systems – 78.66.-w Optical properties of specific thin films – 78.30.-j Infrared and Raman spectra – 71.20.-b Electron density of states and band structure of crystalline solids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: The potassium doped monophosphate tungsten bronzes KxP4W8O32 are two-dimensional metals which show a metal-to-metal transition at a critical temperature which depends on the doping level. The metal-to-metal transition is accompanied by the formation of a commensurate charge density wave with wave vector (π/b,0) which is independent of the doping level. Undoped P4W8O32, on the other hand, has two metal-to-metal transitions which are connected to the formation of incommensurate charge density waves. We measured the infrared reflectivity of the series KxP4W8O32 (x = 0 - 1.57) in the spectral range from 100 to 10 000 cm-1 for room temperature and well below the critical temperature. Polarization-dependent infrared spectra find a two-dimensional behavior in the normal and the charge density wave state and show signatures of hybridization between one- and two-dimensional conduction bands. In undoped P4W8O32 the essentials of the charge density wave state can be understood from the nesting vectors of the calculated Fermi surface and two gaps are observed in the infrared spectra. The gap sizes are a factor of about 2.5 bigger than the predictions from mean-field theory in the weak-coupling limit which suggests medium- or strong electron-phonon coupling. For potassium doped KxP4W8O32 one gap is observed in the charge density wave state. The energetics of the charge density formation may be dominated by the energy required for the lattice modulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100510170004
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  • 4
    Electronic Resource
    Electronic Resource
    Analysis of the first electron-removal states of using polarization dependent angle-resolved photoelectron spectroscopy (2000)
    Springer
    The European physical journal 14 (2000), S. 251-261 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 74.72.Jt Other cuprates - 79.60.-i Photoemission and photoelectron spectra - 71.27.+a Strongly correlated electron systems; heavy fermions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: The first electron-removal states of the layered cuprate Ba2Cu3O4Cl2 were measured using angle-resolved photoelectron spectroscopy. The symmetry and energy-momentum relations of the lowest-lying states were determined and interpreted in terms of the motion of a single hole in the two different planar Cu-O subsystems of the Cu3O4 plane. One subsystem is antiferromagnetic as in the undoped parent compounds of the high-temperature superconductors and the other is paramagnetic and corresponds to the strongly overdoped case. The data are compared to theoretical results on hole dynamics in two-dimensional antiferromagnetic or paramagnetic spin backgrounds. The lineshape, symmetry and dispersion of the first electron-removal states of Ba2Cu3O4Cl2 can be described in terms of Zhang-Rice singlets within a single band model. The photohole lifetime in the paramagnetic subsystem of the Cu3O4 plane is much smaller than with an antiferromagnetic spin background.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100510050127
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  • 5
    Electronic Resource
    Electronic Resource
    Hortus - 1987-, Q. £22(U.K.) £28 (U.S. and Canada). The Neuadd, Rhayader, Powys LD6 5HH, Wales. Ed.: David Wheeler. LCCN sn88-16819. ISSN 0950-1657. Issues examines: no. 1 (Spring 1987); no. 8 (Winter 1988).
    Amsterdam : Elsevier
    Serials Review 15 (1989), S. 92-94 
    Details
    ISSN: 0098-7913
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Information Science and Librarianship
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0098-7913(89)90047-6
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  • 6
    Electronic Resource
    Electronic Resource
    Does obesity explain excess prevalence of diabetes among Mexican Americans? Results of the San Antonio heart study (1983)
    Springer
    Diabetologia 24 (1983), S. 272-277 
    Details
    ISSN: 1432-0428
    Keywords: Type 2 diabetes ; obesity ; Mexican Americans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Obesity and Type 2 (non-insulin-dependent) diabetes mellitus are common in the Mexican American population. It is not clear whether this is merely a specific instance of the more general phenomenon of excess Type 2 diabetes and obesity among poor people, or whether Mexican Americans have a discrete genetic susceptibility to Type 2 diabetes. The latter consideration arises because Mexican Americans are of mixed native American and European ancestry and native Americans may have a genetic predisposition to Type 2 diabetes which Mexican Americans could share. We studied 936 Mexican Americans and 398 Anglo-Americans randomly selected from three socially and culturally distinct neighbourhoods in San Antonio, Texas. Three categories of obesity — lean, average, and obese were defined using the Anglo-American distribution of the sum of the triceps and subscapular skinfold. Mexican Americans were two to four times as likely to fall into the obese category as Anglo-Americans, but within categories, the two ethnic groups were closely matched in terms of sum of skinfolds. The prevalence of Type 2 diabetes, however, was significantly greater in Mexican Americans than in Anglo-Americans even when the comparisons were made within the three obesity categories. The summary prevalence ratio, controlling for obesity, was 2.54 for men (p=0.004) and 1.70 for women (p=0.036). Thus, lean Mexican Americans are still at greater risk of Type 2 diabetes than equally lean Anglo-Americans. Conversely, although Type 2 diabetes prevalence increases as expected with increasing obesity in both ethnic groups, obese Anglo-Americans are still relatively protected compared with equally obese Mexican Americans. Plasma glucose was significantly higher in Mexican Americans than in Anglo-Americans even after controlling for obesity. These results indicate that, although obesity contributes to Type 2 diabetes in Mexican Americans, it does not by itself explain the entire excess prevalence rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282712
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  • 7
    Electronic Resource
    Electronic Resource
    Is microalbuminuria part of the prediabetic state? The Mexico City Diabetes Study (1993)
    Springer
    Diabetologia 36 (1993), S. 1002-1006 
    Details
    ISSN: 1432-0428
    Keywords: Microalbuminuria ; Type 2 (non-insulin-dependent) diabetes mellitus ; dyslipidaemia ; blood pressure ; insulin resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Microalbuminuria is associated with increased cardiovascular mortality in both diabetic and non-diabetic subjects. A number of studies have indicated that insulin resistance, increased blood pressure and dyslipidaemia precede the onset of clinical diabetes. We examined various correlates of microalbuminuria in 1,298 non-diabetic subjects who participated in the Mexico city Diabetes Study, a population-based study of diabetes and cardiovascular risk factors. Both parental history of diabetes and impaired glucose tolerance were significantly associated with microalbuminuria. These results were not explained by differences in age or blood pressure between subjects with or without a parental history of diabetes or impaired glucose tolerance. In addition, subjects with microalbuminuria had increased 2-h insulin and triglyceride concentrations, a higher prevalence of hypertension, and decreased high density lipoprotein cholesterol concentrations relative to subjects without microalbuminuria. These results suggest that microalbuminuria may be a feature of the prediabetic state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02374491
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  • 8
    Electronic Resource
    Electronic Resource
    A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects (1995)
    Springer
    Diabetologia 38 (1995), S. 1328-1336 
    Details
    ISSN: 1432-0428
    Keywords: Insulin resistance syndrome ; low density lipoprotein size ; triglyceride ; high-density lipoprotein ; hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recently, the presence of small dense low density lipoprotein (LDL) has been postulated to be a stronger risk factor for coronary heart disease than large LDL. While small dense LDL has been associated with individual components of the insulin resistance syndrome such as hypertension, high triglyceride level, low high density (HDL) cholesterol, and diabetess mellitus, there has been little work exploring whether LDL size is decreased in subjects with multiple metabolic disorders. We examined the association of LDL size and pattern to specific insulin (which does not cross-react with proinsulin), proinsulin, increased triglyceride, decreased HDL, hypertension and impaired glucose tolerance in 488 non-diabetic subjects from the San Antonio Heart Study. LDL size was significantly related to specific insulin, proinsulin and the fasting proinsulin/insulin ratio. Small dense LDL was significantly associated with high triglyceride level, decreased HDL cholesterol, hypertension and impaired glucose tolerance. LDL size (å) decreased in a stepwise fashion with increasing number of the metabolic disorders described above (zero 262.6±9.4; one 257.0±9.3; two 256.4±9.4; three 249.0±9.1; and four 244.9±9.0). These results were similar in men and women and in non-Hispanic whites and Mexican Americans. The association between LDL size and the number of metabolic disorders remained statistically significant even after adjustment for obesity, body fat distribution, gender, ethnicity, proinsulin and insulin concentrations. Furthermore, decreases in LDL size are also significantly associated with both a selective beta-cell defect (as estimated by the fasting proinsulin/insulin ratio) and insulin resistance (as estimated by the fasting insulin concentrations) although the association was some-what stronger for the latter. We conclude that small dense LDL may form part of the insulin resistance syndrome in non-diabetic subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401766
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  • 9
    Electronic Resource
    Electronic Resource
    A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects (1995)
    Springer
    Diabetologia 38 (1995), S. 1328-1336 
    Details
    ISSN: 1432-0428
    Keywords: Key words Insulin resistance syndrome ; low density lipoprotein size ; triglyceride ; high-density lipoprotein ; hypertension.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recently, the presence of small dense low density lipoprotein (LDL) has been postulated to be a stronger risk factor for coronary heart disease than large LDL. While small dense LDL has been associated with individual components of the insulin resistance syndrome such as hypertension, high triglyceride level, low high density (HDL) cholesterol, and diabetes mellitus, there has been little work exploring whether LDL size is decreased in subjects with multiple metabolic disorders. We examined the association of LDL size and pattern to specific insulin (which does not cross-react with proinsulin), proinsulin, increased triglyceride, decreased HDL, hypertension and impaired glucose tolerance in 488 non-diabetic subjects from the San Antonio Heart Study. LDL size was significantly related to specific insulin, proinsulin and the fasting proinsulin/insulin ratio. Small dense LDL was significantly associated with high triglyceride level, decreased HDL cholesterol, hypertension and impaired glucose tolerance. LDL size (Å) decreased in a stepwise fashion with increasing number of the metabolic disorders described above (zero 262.6 ± 9.4; one 257.0 ± 9.3; two 256.4 ± 9.4; three 249.0 ± 9.1; and four 244.9 ± 9.0). These results were similar in men and women and in non-Hispanic whites and Mexican Americans. The association between LDL size and the number of metabolic disorders remained statistically significant even after adjustment for obesity, body fat distribution, gender, ethnicity, proinsulin and insulin concentrations. Furthermore, decreases in LDL size are also significantly associated with both a selective beta-cell defect (as estimated by the fasting proinsulin/insulin ratio) and insulin resistance (as estimated by the fasting insulin concentrations) although the association was somewhat stronger for the latter. We conclude that small dense LDL may form part of the insulin resistance syndrome in non-diabetic subjects. [Diabetologia (1995) 38: 1328–1336]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401766
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  • 10
    Electronic Resource
    Electronic Resource
    The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed Type II diabetes: the Insulin Resistance Atherosclerosis Study (1999)
    Springer
    Diabetologia 42 (1999), S. 1060-1066 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Proinsulin ; insulin ; insulin secretion ; insulin resistance.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Proinsulin concentrations are increased relative to insulin concentrations in subjects with Type II (non-insulin-dependent) diabetes mellitus. This could be secondary to hyperglycaemia or insulin resistance or due to a defect in insulin secretion. Methods. We investigated the association between fasting insulin, intact proinsulin and the intact proinsulin: insulin ratio with insulin sensitivity, estimated by a frequently sampled intravenous glucose tolerance test and the minimal model and with acute insulin response (AIR) in 182 newly diagnosed Type II diabetic subjects aged 40 to 69 years. None of the subjects was receiving hypoglycaemic medication. Results. Insulin sensitivity correlated inversely with fasting insulin (r s = –0.42) and intact proinsulin (r s = –0.32) (p 〈 0.001). The intact proinsulin:insulin ratio was not correlated with insulin sensitivity. AIR correlated positively with intact proinsulin (r s = 0.23) and inversely with the intact proinsulin:insulin ratio (r s = –0.29, p 〈 0.001). Fasting glucose correlated positively with intact proinsulin (r s = 0.34) and the intact proinsulin:insulin ratio (r s = 0.24, p 〈 0.001). The intact proinsulin:insulin ratio increased by decreasing AIR (quartiles of AIR from high to low: 7.8, 8.2, 9.7 and 12.1 %, p 〈 0.001). This association was independent of age, sex, ethnicity, body mass index, fasting glucose, and insulin sensitivity. Conclusion/interpretation. Insulin resistance (low insulin sensitivity) was not related to the intact proinsulin:insulin ratio in subjects with Type II diabetes. In contrast, both low AIR and high fasting glucose concentrations were associated with a disproportionate increase in proinsulin concentration. These results suggest that increased intact proinsulin:insulin ratio is a marker of a defect in insulin secretion in Type II diabetic subjects. [Diabetologia (1999) 42: 1060–1066]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051271
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