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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of Alveoloar Bone Loss During Maturation of the Rat (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Gerodontology 5 (1986), S. 0 
    Details
    ISSN: 1741-2358
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of dichloromethylene diphosphonate (C12MDP) on previously described maturational bone loss were quantified in 24 Wistar rats. Four groups of six animals each were treated daily from 18 to 28 weeks of age with a subcutaneous injection of a 0.1, 1.0 or 10mg/kg dose of C12MDP or were sham treated with 0.9% NaC1. Prior to sacrifice, all animals were double-labeled with tetracycline. The interdental bone between first and second maxillary molars was evaluated on decalcified stained sections and on undecalcified ground sections by digitizing morphometry. No significant differences in periodontal ligament width, bone height, osteoclast numbers or tetracycline labeled surface were detected. Significantly greater bone area (p〈0.01) and bone width (p〈0.005), and significantly fewer osteoblasts/mm of bone surface (p〈0.001) were measured in rats treated with 10 mg/kg doses of C12MDP; and a dose response was demonstrated. It was concluded that C12MDP prevented interdental bone loss by inhibiting bone resorption, and that bone formation may have been indirectly reduced through a coupling mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1741-2358.1986.tb00065.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Maturational Changes in Alveolar Bone of Adult Rats (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Gerodontology 4 (1985), S. 0 
    Details
    ISSN: 1741-2358
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Structural and cellular alterations of interproximal alveolar bone were quantified by histomorphometry in 36 Wistar rats over an 18 week period. Half of the rats were fed a standard diet and half were fed a high-sucrose diet from time of weaning. Six animals from each diet group were sacrificed at 10, 18 and 28 weeks of age, one hour after labeling with tritiated thymidine. Autoradiographs were prepared from histological sections, and the interproximal area between first and second maxillary molars was evaluated, Periodontal ligament width, cell populations and cell proliferation were reduced by 18 weeks of age. By 28 weeks of age, significant reductions of bone dimensions were detected and a further decrease in fibroblast proliferation was evident. The influence of diet on the changes observed was relatively minor. Evidence from this investigation supports the concept that changes in alveolar bone are initiated early in the life span of the rat, and provides a quantitative basis for future use of the rat model in similar studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1741-2358.1985.tb00246.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Trabecular bone structural variation in biopsy sites of the beagle ilium (1982)
    Springer
    Calcified tissue international 34 (1982), S. 391-395 
    Details
    ISSN: 1432-0827
    Keywords: Ilium ; Trabecular bone ; Biopsy ; Variability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Iliac trabecular bone sites were studied in 2 male and 2 female adult beagles to determine normal structural variability among different sites, and to identify transilial biopsy sites with minimum structural variation. Only sites that provided adequate amounts of trabecular bone were studied. Trabecular bone area and perimeter were measured on microradiographs of ground sagittal sections using a Quantimet 720 image analyzer, and percent bone, perimeter to area ratio, and mean trabecular width were calculated. Over 100% variation was found in the parameters studied among sections from different sites within the same animal. However, variability was minimal among sections obtained more than 2 mm from the lateral or medial cortex within the most caudal sites evaluated. Two sites appropriate for sampling with an 8 mm trephine were identified as being centered over the following points: (a) a point 7 mm caudal to the cranial dorsal spine and 7 mm ventral to the tuber sacrale, and (b) a point 7 mm caudal to the cranial ventral spine and 7 mm dorsal to the tuber coxae. Comparison of data obtained from males and females indicated that sampling variation may also be reduced by using dogs of one sex and by preferential use of males.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411273
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    Paper (German National Licenses)
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