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  • 1
    Electronic Resource
    Electronic Resource
    Increased airway epithelial Na + absorption produces cystic fibrosis-like lung disease in mice (2004)
    [s.l.] : Nature Publishing Group
    Nature medicine 10 (2004), S. 487-493 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in defective epithelial cAMP-dependent Cl− secretion and increased airway Na+ absorption. The mechanistic links between these altered ion transport processes and the pathogenesis of cystic fibrosis lung ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1028
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  • 2
    Electronic Resource
    Electronic Resource
    Morphometric Approaches for Evaluating Pulmonary Toxicity in Mammals: Implications for Risk Assessment (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 14 (1994), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Recent advances in quantitative morphology provide all the tools necessary to obtain structural information in the lung that can be quantified and interpreted in the three-dimensional world of toxicology. Structural hierarchies of conducting airways and parenchyma of the lung provide: (1) numbers of cells per airway, lobe, or lung; (2) surface areas of cells, airways, and alveoli; (3) length of airways and vessels; and (4) volumes of cells, alveoli, airways, vessels, and individual lobes or the entire lung. Unbiased sampling of these subcompartments of the lung requires fractionation of lobes or individual airways. Individual airways of proximal and distal generations are obtained by airway microdissection along one axial pathway and comparisons made between airway generations. Vertical sections of selected airways are used to sample epithelium and interstitium. Using this unbiased approach of quantitative morphology, we have shown that inhalation of low ambient concentrations of ozone ([O3]0.15 ppm) near or at the United States National Ambient Air Quality Standard (NAAQS) (0.12 ppm O3) induces significant alterations in bronchiolar epithelium and interstitium in nonhuman primates but not rats. The alterations do not appear to be concentration- or time-dependent, thereby bringing into question the current NAAQS that may be at or above the threshold for distal airway injury in primates. Unbiased morphometric methods are critical in a quantitative evaluation of toxicological injury of mammalian tracheobronchial airways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1539-6924.1994.tb00244.x
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  • 3
    Electronic Resource
    Electronic Resource
    Nonolfactory surface epithelium of the nasal cavity of the bonnet monkey: A morphologic and morphometric study of the transitional and respiratory epithelium (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 180 (1987), S. 266-279 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The purpose of the present study was to characterize ultrastructurally the nonolfactory nasal epithelium of a nonhuman primate, the bonnet monkey. Nasal cavities from eight subadult bonnet monkeys were processed for light microscopy, and scanning and transmission electron microscopy. Nonolfactory epithelium covered the majority of the nasal cavity and consisted of squamous (SE), transitional (TE), and respiratory epithelium (RE). Stratified SE covered septal and lateral walls of the nasal vestibule, while ciliated pseudostratified RE covered most of the remaining nasal cavity. Stratified, nonciliated TE was present betwen SE and RE in the anterior nasal cavity. This epithelium was distinct from the other epithelial populations in abundance and types of cells present. TE was composed of lumenal nonciliated cuboidal cells, goblet cells, small mucous granule (SMG) cells, and basal cells, while RE contained ciliated cells, goblet cells, SMG cells, basal cells, and cells with intracytoplasmic lumina lined by cilia and microvilli. TE and RE contained similar numbers of total epithelial cells and basal cells per millimeter of basal lamina. TE was composed of more SMG cells but fewer goblet cells compared to RE. We conclude that nonolfactory nasal epithelium in the bonnet monkey is complex with distinct regional epithelial populations which must be recognized before pathologic changes within this tissue can be assessed adequately.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001800308
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    Paper (German National Licenses)
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