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  • 1
    Electronic Resource
    Electronic Resource
    Amphetamine analogs. II. Methylated phenethylamines (1970)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 13 (1970), S. 134-135 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00295a034
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    RESEARCH TRAINING IN ALCOHOLISM (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 178 (1971), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1971.tb30716.x
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  • 3
    Electronic Resource
    Electronic Resource
    Biological activities of some 5-substituted N,N-dimethyltryptamines, α-methyltryptamines, and gramines (1970)
    Springer
    Psychopharmacology 16 (1970), S. 385-394 
    Details
    ISSN: 1432-2072
    Keywords: 5-Substituted N,N-Dimethyltryptamines, α-Methyltryptamine, and Gramines ; Monoamine Oxidase Inhibitors ; Psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three series of derivatives of N,N-dimethyltryptamine, α-methyltryptamine and gramine bearing substituents of varying electronic nature on the C-5 position were tested for acute toxicity, effect on barbiturate sleeping time, antireserpine effect, swim maze, variable interval conditioned behavior, and inhibition of monoamine oxidase. No correlation could be made between the electronic effects and their pharmacological activities. It was thus suggested that there exist different pharmacological receptors for the tryptamines and gramines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404849
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  • 4
    Electronic Resource
    Electronic Resource
    Self administration of minor tranquilizers as a function of conditioning (1968)
    Springer
    Psychopharmacology 13 (1968), S. 81-88 
    Details
    ISSN: 1432-2072
    Keywords: Psychiatry ; Psychology ; Drug Addiction ; Reinforcement ; Learning ; Conditioning ; Animal Behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An attempt was made to develop pronlonged preferences in rats for quinine, LSD, nicotinic acid, meprobamate and chlordiazepoxide. It was found that forced ingestions of the drugs had no enduring effects on subsequent free choice preference intakes. When the animals were conditioned to drink the drugs in order to obtain food pellets, it was found that they developed increased preferences for meprobamate and chlordiazepoxide which endured over a 21 day free choice period. The results are interpreted as showing that through pairing with food several of the drugs acquired secondary reinforcing properties which were responsible for their sustained drinking by the animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401621
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  • 5
    Electronic Resource
    Electronic Resource
    Behavioral effects in rhesus monkeys of repeated intravenous doses of δ-9-tetrahydrocannabinol (1972)
    Springer
    Psychopharmacology 26 (1972), S. 297-306 
    Details
    ISSN: 1432-2072
    Keywords: Chronic Drug Effects ; δ-9-THC Tolerance ; Monkey ; Intravenous Route
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In two separate experiments effects were evaluated of chronic administration of δ-9-THC (i.v.) on the behavior of rhesus monkeys trained on a multiple schedule of food reinforcement and a shock avoidance schedule. Rapid tolerance to drug effect was observed on avoidance responding; but only partial tolerance on food reinforced responding. Only a minor degree of tolerance was noted on gross behavior. In both experiments, tolerance to the drug carried over a 30-day drugfree period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422705
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  • 6
    Electronic Resource
    Electronic Resource
    Suppression of the cardiac conditioned response by Δ-9-tetrahydrocannabinol: A comparison with other drugs (1976)
    Springer
    Psychopharmacology 50 (1976), S. 159-163 
    Details
    ISSN: 1432-2072
    Keywords: Δ-9-Tetrahydrocannabinol ; Anxiety ; Cardiac conditioned response ; Rhesus monkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using classical conditioning procedures, the cardiac conditioned response (CCR) was established by pairing one of two tones with the delivery of a peripheral electric shock in Rhesus monkeys. The other tone had no terminal consequence. Such a procedure results in an anticipatory ‘anxiety’ or ‘fear’ response to the impending shock signalled by the reinforced tone. The heart rate before the tone in two of the animals was characterized by tachycardia and by bradycardia in the other animal. The effect of intravenous Δ-9-tetrahydrocannabinol (THC) was compared to various doses of diazepam, chlorpromazine, and morphine. The results indicate that THC blocks the CCR in a dose-related manner. The effects of THC were similar to diazepam, an anti-anxiety drug. Chlorpromazine and morphine affected the conditioned response in an unreliable manner, and both drugs would attenuate the response in some cases and potentiate it in other instances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430486
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  • 7
    Electronic Resource
    Electronic Resource
    Evaluation of reinforcing capability of delta-9-tetrahydrocannabinol in rhesus monkeys (1974)
    Springer
    Psychopharmacology 37 (1974), S. 23-29 
    Details
    ISSN: 1432-2072
    Keywords: Drug Self-Administration ; Delta-9-THC ; Monkey ; Intravenous Route
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Harnessed rhesus monkeys, surgically prepared with indwelling jugular catheters, were given access by means of remotely controlled infusion pumps to unlimited quantities of delta-9-trans-tetrahydrocannabinol. Naive monkeys as well as monkeys which were automatically infused with THC for over 28 days did not self-administer THC. Monkeys which had a history of multiple drug self-administration also did not self-infuse THC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426679
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  • 8
    Electronic Resource
    Electronic Resource
    Behavioral, biochemical and maturation effects of early DL-para-chlorophenylalanine treatment (1971)
    Springer
    Psychopharmacology 19 (1971), S. 334-346 
    Details
    ISSN: 1432-2072
    Keywords: Phenylketonuria ; DL-para-Chlorophenylalanine ; Activity ; Maturation ; Conditioned Response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract DL-para-Chlorophenylalanine was administered to albino rats daily from within eight hours of birth for various lengths of time during the 30 day postnatal cortical development period. In experiment one, whole brain serotonin and plasma phenylalanine were measured 24 and 72 h post treatment in 7, 14, 21, and 28 day rats. The data are interpreted as supporting the hypothesis that DL-para-chlorophenylalanine may be used to institute the biochemical characteristics of phenylketonuria. The DL-para-chlorophenylalanine-treated Ss weighed significantly less at 14 days of age and thereafter and, also, were less strong. One hundred mg/kg DL-para-chlorophenylalanine was administered daily from birth through day 30 for experimental Ss of studies two and three. In experiment two maturation indices were reported to be retarded in drug-treated Ss for behaviors involving the skeletal-muscular system and activity measures were reported to be lower at 25, 45, and 121 days of age. Experiment three showed that acquisition of a conditioned pole climb avoidance and/or escape response measured at 180 days of age was poor in early drug-treated Ss. These data were interpreted as indicating that early DL-para-chlorophenylalanine-treated Ss show some degree of behavioral deficit at maturity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404378
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  • 9
    Electronic Resource
    Electronic Resource
    Discriminative response control by d-amphetamine and related compounds in the rat (1974)
    Springer
    Psychopharmacology 36 (1974), S. 347-356 
    Details
    ISSN: 1432-2072
    Keywords: d-Amphetamine ; l-Amphetamine ; Para-Hydroxyamphetamine ; Appetitive Discrimination ; Drug Cues
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to discriminate between two levers utilizing drug-induced physiological states as discriminative stimuli. Drug injections were associated with reinforcement of response on one lever and saline was associated with reinforcement on the other lever. At equimolar doses, d- and l-amphetamine but not para-hydroxyamphetamine, functioned effectively as cues. Following training, stimulus generalization between these drugs was evaluated. Transfer of response control was observed between the d- and l-isomers, and between para-hydroxyamphetamine and saline in rats trained to utilize d- or l-amphetamine versus saline as cues. These findings suggest the importance of central pharmacological activity in this type of response control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422566
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