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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Addiction 89 (1994), S. 0 
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: We describe the epidemiology of nicotine dependence and Us association with other substance use and psychiatric disorders. Data came from a random sample of young adults, 21–30 years of age, in the Detroit, Michigan metropolitan area. The NIMH Diagnostic Interview Schedule was used to ascertain DSM-III-R disorders. Lifetime prevalence of nicotine dependence was 20%. Higher rates were observed in whites, persons with low education and persons who were separated or divorced. Males and females with nicotine dependence had significantly increased odds for alcohol and illicit drug disorders, major depression and one or more anxiety disorder, as compared to non-dependent smokers and non-smokers combined. Among smokers, lifetime prevalence of illicit drug disorders other than marijuana alone, major depression and any anxiety disorder were significantly higher in dependent than non-dependent people. Major depression was associated specifically with nicotine dependence, an association explained in part by neuroticism. This finding suggests that the personality trait of neuroticism might constitute a common predisposition for major depression and nicotine dependence.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 281 (1976), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 238 (1972), S. 463-465 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have now investigated the effects of various doses of THC on attack behaviour in mice, using an experimental design that also assessed effects on a learned position response. To determine non-specific effects of the drug, we measured spontaneous activity. We also measured whole brain amines, for ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 31 (1973), S. 157-166 
    ISSN: 1432-2072
    Keywords: Δ 9-tetrahydrocannabinol ; Predatory Aggression ; Rat ; Serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Δ 9-tetrahydrocannabinol inhibits predatory aggression in rats. Increases in the degree of inhibition are obtained with increasing dosages of the drug. Although sex and strain of the subjects varied nonsystematically, inhibition of predatory aggression uniformly was found to be dose related. Readministration of Δ 9-tetrahydrocannabinol did not effect motor activity measures at dose levels which inhibit aggression. Administration of Δ 9-tetrahydrocannabinol increases whole brain serotonin, while norepinepherine is largely unaffected, indicating that the anti-aggressive effect may be mediated, in part, by serotonergic mechanisms.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 19 (1971), S. 334-346 
    ISSN: 1432-2072
    Keywords: Phenylketonuria ; DL-para-Chlorophenylalanine ; Activity ; Maturation ; Conditioned Response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract DL-para-Chlorophenylalanine was administered to albino rats daily from within eight hours of birth for various lengths of time during the 30 day postnatal cortical development period. In experiment one, whole brain serotonin and plasma phenylalanine were measured 24 and 72 h post treatment in 7, 14, 21, and 28 day rats. The data are interpreted as supporting the hypothesis that DL-para-chlorophenylalanine may be used to institute the biochemical characteristics of phenylketonuria. The DL-para-chlorophenylalanine-treated Ss weighed significantly less at 14 days of age and thereafter and, also, were less strong. One hundred mg/kg DL-para-chlorophenylalanine was administered daily from birth through day 30 for experimental Ss of studies two and three. In experiment two maturation indices were reported to be retarded in drug-treated Ss for behaviors involving the skeletal-muscular system and activity measures were reported to be lower at 25, 45, and 121 days of age. Experiment three showed that acquisition of a conditioned pole climb avoidance and/or escape response measured at 180 days of age was poor in early drug-treated Ss. These data were interpreted as indicating that early DL-para-chlorophenylalanine-treated Ss show some degree of behavioral deficit at maturity.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 46 (1976), S. 229-233 
    ISSN: 1432-2072
    Keywords: Methamphetamine ; Cocaine ; Self-administration ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A procedure for studying intravenous drug self-administration in the cat is described. Ten cats were given 24-h access to methamphetamine reinforcement (0.04 mg/kg/inj.). The subjects maintained a significantly higher response rate for drug reinforcement than for saline. The pattern of self-administration over days alternated between periods of high and low drug intake. Six additional cats were used to study the effect of dose per injection on methamphetamine self-administration under conditions of limited access. When methamphetamine was substituted at various doses per infusion in animals maintained on cocaine reinforcement, response rate was shown to be an inverted U-shaped function of dose. These studies demonstrate that methamphetamine is a reinforcer in the cat and its patterns of intake under conditions of 24-h and limited access resemble other species.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 63 (1979), S. 151-153 
    ISSN: 1432-2072
    Keywords: Discriminative stimulus properties ; Psychomotor stimulants ; Cat ; d-Amphetamine ; Clozapine ; Cocaine ; Morphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cats were trained to choose between two levers of an operant chamber using interoceptive cues provided by d-amphetamine or saline as the discriminative stimuli. Following training, stimulus generalization was observed to additional doses of d-amphetamine and cocaine, but not to morphine. Clozapine blocked the generalization of the drug discrimination response to d-amphetamine, but had no effect on generalization to cocaine. These data indicate that discriminative stimulus properties of psychomotor stimulants, previously described in rats, are similar in cats.
    Type of Medium: Electronic Resource
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