ISSN:
1432-2072
Keywords:
Δ 9-tetrahydrocannabinol
;
Predatory Aggression
;
Rat
;
Serotonin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Δ 9-tetrahydrocannabinol inhibits predatory aggression in rats. Increases in the degree of inhibition are obtained with increasing dosages of the drug. Although sex and strain of the subjects varied nonsystematically, inhibition of predatory aggression uniformly was found to be dose related. Readministration of Δ 9-tetrahydrocannabinol did not effect motor activity measures at dose levels which inhibit aggression. Administration of Δ 9-tetrahydrocannabinol increases whole brain serotonin, while norepinepherine is largely unaffected, indicating that the anti-aggressive effect may be mediated, in part, by serotonergic mechanisms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00419815
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