Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    The role of the spleen in tumor bearing host: I. Characterization of spleen cells in tumor-bearing mice (1984)
    Springer
    Surgery today 14 (1984), S. 61-71 
    Details
    ISSN: 1436-2813
    Keywords: the role of spleen ; tumor-bearer ; splenectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Morphologic changes of the spleen and dynamic changes of biologic activity of spleen cells from C3H/HeJ mice bearing methylcholanthrene induced fibrosarcoma (MCA-F) were investigated in different stages of tumor growth, using local adoptive transfer assay (LATA). The spleen size, weight and the number of spleen cells increased with the tumor growth. In early and late stages of tumor growth, tumor-bearing mice possessed non-specific tumor-enhancing cells which were radioresistant (700 rads), phagocytic and adherent, suggesting that they were macrophages. On the other hand, in middle stages of tumorgenesis, tumor-bearing mice possessed specific cytotosic cells which were radiosensitive (700 rads) and anti-Thy 1.2 serum positive, suggesting that they were T-cells. Thus, the appearance of tumor-enhancing cells was earlier than cytotoxic cells in MCA-F bearing host, and the balance of tumor-enhancing and cytotoxic cells may influence the tumor outgrowth in different stages of tumorgenesis. The spleen serves as a reservoir of factors which either abrogate cell mediated resistance or stimulate neoplastic growth, or as the source of cytotoxic cells, at certain times of tumor burden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469605
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Spontaneous blastogenesis assay for detection of renal allograft rejection in man (1983)
    Springer
    Surgery today 13 (1983), S. 196-201 
    Details
    ISSN: 1436-2813
    Keywords: renal transplantation ; immunological monitoring ; spontaneous blastogenesis ; acute rejection crisis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In attempts to assess the possibility of allograft rejection, serial assays of spontaneous blastogenesis (SB) by uptake of tritium thymidine in 50 μl whole blood were performed in 72 consecutive renal allograft recipients. Of 79 clinically diagnosed rejection episodes, 65 (82 per cent) had an associated elevation of SB values, and 14 (18 per cent) showed false negative results. In 38 (59 per cent) of 65 episodes in which the elevations of SB values were observed, the elevations preceded the clinical diagnosis by 1–7 days. Although large doses of steroids did not affect the values of SB, false positive elevations which were mainly caused by systemic infections occurred in 12 cases. There was no significant association between severity of rejection crisis and the maximum value of SB in the course. The SB assay requiring only a small amount of blood can be accomplished within 4–5 hours and provides a simple means of assessing and predicting host's immune responsiveness to the histocompatibility antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469476
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Analysis of data on 170 consecutive patients transplanted with kidneys from living relatives (1983)
    Springer
    Surgery today 13 (1983), S. 493-501 
    Details
    ISSN: 1436-2813
    Keywords: kidney transplantation ; living donors ; graft survival rate ; HLA typing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Graft survival, mortality, histocompatibility and rehabilitation were studied in 170 consecutive patients receiving kidneys from living relatives. Average follow-up was 5 years and one month with a mininum post-transplant evaluation of 6 months. Overall patient survival was 93 per cent at one year and there was a remarkable decline thereafter. Overall graft survival was 84 per cent at one year, 73 per cent at three, and 67 per cent at five years. Among the 76 patients treated since 1979, both patients and graft survival have improved: 93 per cent and 80 per cent at three years, respectively, because of a decrease in serious complications. Although no correlation was found between HLA-A and B loci matching and graft survival in patients with no mismatch in the HLA-DR locus, there was a significantly higher gratt survival. Infection, the leading cause of death especially in the early post-transplant period, has been brought under control. Aseptic necrosis of the femoral head which occurred in 27 (16 per cent) patients proved to be the most difficult problem. The majority of patients are functioning well socially and vocationally and reproductive functions have been restored. Transplantation offers a better quality of life for patients with chronic renal failure, as compared to hemodialysis. The increased procurement of cadaver kidneys must be given attention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469492
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The role of the spleen in tumor bearing host: II. The influence of splenectomy in mice (1984)
    Springer
    Surgery today 14 (1984), S. 72-77 
    Details
    ISSN: 1436-2813
    Keywords: the role of spleen ; tumor-bearer ; splenectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of splenectomy on neoplastic outgrowth was examined prior to and after implantation of methylcholanthrene-induced C3H/He murine tumors. Splenectomy performed 12 days before tumor inoculation did not affect the tumor outgrowth, however, both splenectomy and sham operation performed shortly before tumor inoculation resulted in significant tumor facilitation compared with the non-operated group, suggesting that this accelerated tumor was not related to the presence or absence of splenic tissue, but rather to systemically-induced immunosuppression. While splenectomy performed 6, 9, 12 days after tumor inoculation did not alter the tumor growth, splenectomy performed early (3 days) or late stage (20 days) after tumor cell challenge revealed a retarded neoplastic outgrowth, compared with the sham operated group. These results suggest that splenectomy in very early and late stages of tumor-bearing host may be effective for tumor treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469606
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    A small pulsatile pump for extracorporeal circulation (1977)
    Springer
    Surgery today 7 (1977), S. 90-95 
    Details
    ISSN: 1436-2813
    Keywords: Extracorporeal circulation ; pulsatile pump ; cam ; coil spring ; Bellofram rolling diaphragm ; free length ; set length
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A new pulsatile pump was constructed with variable beat rate and the stroke volume, controlled systolic maximum pressure and a very steep built-up curve, to be used for extracorporeal circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469391
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    A patient with gastric carcinoma improved remarkably on intraperioneal OK-432 therapy (1982)
    Springer
    Surgery today 12 (1982), S. 434-441 
    Details
    ISSN: 1436-2813
    Keywords: gastric cancer ; intraperitoneal OK-432 ; immunotherapy ; anti-human macrophage serum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with an abdominal tumor and gastric cancer was treated with intraperitoneal OK-432 alone. Her general condition improved and the abdominal mass diminished significantly. The fluoroscopic radiography and gastroduodenal fiberscopic examinations revealed a slight improvement. Four months after the initiation of OK-432 therapy, microscopic examination of the biopsy specimen disclosed degenerated tumor cells with a pronounced accumulation of lymphocytes and large monocytes which were ascertained to be macrophages by the fluorescent antibody technique using anti-macrophage serum. This study revealed one possible mechanism of the antitumor action of OK-432.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02469834
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Levamisole in postoperative adjuvant immunochemotherapy for gastric cancer (1984)
    Springer
    Cancer immunology immunotherapy 18 (1984), S. 13-18 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The usefulness of LMS in postoperative immunochemotherapy of gastric cancer was investigated. In compliance with the protocol, MMC was given at a dose of 20 mg on the day of gastrectomy, and an additional 10 mg on the next day IV. The patients receiving 600 mg Tegafur daily were then divided into two groups according to whether LMS was also given or not. LMS was administered for 3 days before the operation in a daily dose of 150 mg and for 1 year or more after operation according to a schedule of 3 days' administration followed by an 11-day interval. The 2-year follow-up demonstrated that in stage III patients, the LMS (+) regimen was superior to the LMS (−) regimen, since the former prolonged the relapse-free interval significantly. The survival rate for stage III disease was also significantly higher in the LMS (+) than in the LMS (−) group. There was no significant difference in the incidence of subjective or objective side-effects between two groups. The incidence of agranulocytosis was comparable in the two groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205393
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...