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  • 1
    Electronic Resource
    Electronic Resource
    Periodontal disease in HIV-infected patients in relation to lymphocyte subsets and specific micro-organisms (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 18 (1991), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Visible plaque index (VPI), gingival bleeding index (GBI) and pocket depth (PD) were analyzed in relation to potential periodontal pathogenic microorganisms and peripheral numbers of T4+ and T8+ lymphocyte subsets in 10 patients with human immunodeficiency virus (HIV) infection, 10 patients with AIDS related complex (ARC) and 10 patients with acquired immune deficiency syndrome (AIDS). 10 healthy persons served as controls. Periodontal disease in patients with more advanced stages of HIV infection were related to the severity of the systemic disease, and to decreasing numbers of T4+ lymphocytes in peripheral blood, but not to VPI or the occurrence of periodontal pathogenic micro-organisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1991.tb00423.x
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  • 2
    Electronic Resource
    Electronic Resource
    Impact of different betalactam antibiotics on the normal human flora, and colonization of the oral cavity, throat and colon (1982)
    Springer
    Infection 10 (1982), S. 120-124 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Sechs Personen erhielten sieben Tage lang Phenoxymethylpenicillin oral in Dosen von 800 mg zweimal täglich. Sechs weitere Personen erhielten sieben Tage lang Bacampicillin in Tablettenform in Dosen von 400 mg dreimal täglich. Zur Kultivierung aerober und anaerober Bakterien wurden Speichel, Rachenabstriche und Stuhlproben entnommen. Im Beobachtungszeitraum waren nur geringe Veränderungen der normalen Speichel- und Rachenflora und keine Veränderungen der faekalen Flora zu beobachten. Sechs Patienten erhielten über einen Zeitraum von zwölf Stunden 2 g Cefoxitin in sechsstündlichen Abständen parenteral appliziert. Daraufhin traten ausgeprägte Veränderungen in der Zusammensetzung der Colonflora auf. Unter den aeroben Bakterien nahmen die Enterobakterien ab, cefoxitinresistente Enterokokken nahmen zu; unter den anaeroben Bakterien war die Zahl der gramnegativen Stäbchen reduziert. In der Phase nach der Antibiotikaapplikation nahm die Zahl aller cefoxitinresistenten Stämme ab, und die supprimierten Enterobakterien und Bacteroidesstämme vermehrten sich wieder.
    Notes: Summary Phenoxymethylpenicillin was given orally in doses of 800 mg twice daily for seven days to six patients, and bacampicillin was given in doses of 400 mg three times per day for seven days to another six patients. Saliva, throat and faecal specimens were taken for cultivation of aerobic and anaerobic bacteria. Only small changes in the normal saliva and throat flora were observed, and no changes in the faecal flora were noticed during the observation period. Cefoxitin was administered parenterally in doses of 2 g at 6 h intervals for 12 h to six other patients. Pronounced changes in the colon flora occurred. Of the aerobic bacteria, enterobacteria decreased and cefoxitin-resistant enterococci increased in number; of the anaerobic bacteria, gramnegative rods decreased in number. At the end of the administration period, all cefoxitin-resistant strains decreased, and suppressed enterobacteria and bacteroides increased in number.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01816741
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  • 3
    Electronic Resource
    Electronic Resource
    Clindamycin versus phenoxymethylpenicillin in the treatment of acute orofacial infections (1992)
    Springer
    European journal of clinical microbiology & infectious diseases 11 (1992), S. 1129-1135 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The efficacy of clindamycin and phenoxymethylpenicillin in the treatment of orofacial infections was compared in a randomised study in 60 patients: 30 patients received clindamycin 150 mg every 6 h for seven days, and 30 received phenoxymethylpenicillin 1 g every 12 h for seven days. Where indicated incision and drainage were carried out. All patients but one in each group responded satisfactorily to treatment. Although the clindamycin group had a shorter duration of pain, swelling and fever and more favourable laboratory findings, the differences between the groups were not statistically significant. Of the 60 microbiological specimens 23 yielded only anaerobic bacteria, 34 both anaerobic and aerobic bacteria, two aerobic bacteria only and one no growth. In the penicillin group one case of severe diarrhoea occurred, and six patients in the clindamycin group had moderate to severe gastrointestinal discomfort, including one case ofClostridium difficile associated diarrhoea. This difference was however not statistically significant. The results support the continued use of penicillin for treatment of orofacial infections, with clindamycin serving as an effective alternative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01961131
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of prophylactic administration of cefaclor on transient bacteremia after dental extraction (1996)
    Springer
    European journal of clinical microbiology & infectious diseases 15 (1996), S. 646-649 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was undertaken to investigate the effects of prophylactic administration of cefaclor on bacteremia after dental extraction. Thirty-nine patients were randomly assigned to receive either 1 g cefaclor (19 patients) or placebo (20 patients) 1 h prior to dental extraction. Blood samples for microbiological investigation were collected before, during, and 10 min after surgery, and were processed by lysis filtration under anaerobic conditions. The incidence of bacteremia with viridans streptococci was 79% in the cefaclor group and 50% in the placebo group during extraction. No difference in the incidence or magnitude of bacteremia was observed when the two patient groups were compared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01691150
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison between two non-absorbable antibiotic regimens for decontamination of the oropharynx (1984)
    Springer
    Infection 12 (1984), S. 349-354 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 14 gesunden Personen wurde die Mikroflora des Oropharynx untersucht. Sieben Personen erhielten ein Regime zur lokalen Dekontamination, das gegen aerobe grammegative Stäbchen und gegen Pilze wirkt und aus 1% Polymyxin B, 3% Neomycin und 3% Amphotericin B besteht. Sieben weitere Personen erhielten ein anderes Regime aus mehreren Medikamenten, darunter auch eine Substanz gegen grampositive Bakterien, bestehend aus 1% Polymyxin B, 1% Neomycin, 3% Amphotericin B und 0,5% Vancomycin. Beide Dekontaminations-Regime zeigten protektive Wirkung gegen neue Kolonisation des Oropharynx mit Pilzen und gramnegativen Stäbchen. Eine Suppression grampositiver Kokken wurde nur bei den Personen beobachtet, die das Regime mit Vancomycin erhielten.
    Notes: Summary Fourteen healthy individuals were studied regarding the oropharyngeal microflora. Seven subjects were given a non-absorbable multi-drug regimen, consisting of 1% polymyxin B, 3% neomycin and 3% amphotericin B, that was directed against aerobic gram-negative rods and fungi for local decontamination of the oropharynx. Seven others were given another multi-drug regimen consisting of 1% polymyxin B, 1% neomycin, 3% amphotericin B and 0.5% vancomycin, that also included an agent directed against gram-positive bacteria. Both decontamination regimens were found to protect from new colonization with fungi and gram-negative rods in the oropharynx. Suppression of gram-positive cocci was only observed in those subjects receiving the regimen containing vancomycin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01651151
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of bacampicillin on human mouth, throat and colon flora (1979)
    Springer
    Infection 7 (1979), S. S446 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bacampicillin wurde in Tabletten- oder Sirupform in Dosen von 400 mg dreimal täglich für sieben Tage an zwölf Personen verabreicht. Speichel-Rachensekret-und Stuhlproben wurden über einen Zeitraum von vierzehn Tagen abgenommen und kulturell auf aerobe und anaerobe Bakterien untersucht. Bei den Personen, die Tabletten erhielten, waren keine Veränderungen der Mund-, Rachen- und Darmflora zu sehen. Hingegen fand sich bei den Personen, die Sirup erhielten, eine Erniedrigung der Anzahl aerober und anaerober Bakterien. Eine erhöhte Resistenz gegen Ampicillin bei den isolierten Bakterienstämmen wurde nicht festgestellt. Bacampicillin wurde gut vertragen, gastrointestinale Störungen traten nicht auf.
    Notes: Summary Bacampicillin was given as tablets or syrup in doses of 400 mg three times per day for seven days to twelve subjects. Saliva, throat and faecal specimens were taken during fourteen days for cultivation of aerobic and anaerobic bacteria. No changes in the oral, throat and faecal flora were seen in the subjects receiving tablets while there was a decrease in the number of aerobic and anaerobic bacteria in those subjects receiving syrup. No increased resistance to ampicillin were found in the isolated bacterial strains. Bacampicillin was well-tolerated and no gastro-intestinal disturbances were experienced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01659768
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  • 7
    Electronic Resource
    Electronic Resource
    Microbial colonization of the oropharynx, esophagus and stomach in patients with gastric diseases (1985)
    Springer
    European journal of clinical microbiology & infectious diseases 4 (1985), S. 49-51 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The microbial colonization of the oropharynx, the esophagus and the stomach were studied in 60 patients. Patients with gastritis, carcinoma and a history of gastric resection harboured more microorganisms in their stomachs than patients with gastric or duodenal ulcers. Patients with gastric carcinoma were colonized with the highest numbers of different microorganisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02148660
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  • 8
    Electronic Resource
    Electronic Resource
    Detection of anaerobic bacteria in blood cultures by lysis filtration (1985)
    Springer
    European journal of clinical microbiology & infectious diseases 4 (1985), S. 404-407 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An anaerobic adaptation of the lysis-filtration system for detection of anaerobic microorganisms in blood is described. The method was compared with a conventional broth bottle system in detection of anaerobic bacteremia after oral surgery. Of 43 blood samples obtained during and after surgery, 31 were positive with the lysis-filtration system and 17 were positive with the broth bottle system. Sixteen aerobic and 62 anaerobic strains were isolated with the lysis-filtration system versus 9 aerobic and 22 anaerobic strains with the broth bottles. The lysis-filtration technique was thus superior to the conventional broth bottle method in detecting anaerobic bacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02148693
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of erythromycin and clindamycin on the indigenous human anaerobic flora and new colonization of the gastrointestinal tract (1982)
    Springer
    European journal of clinical microbiology & infectious diseases 1 (1982), S. 38-48 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Erythromycin and clindamycin were given orally to ten subjects in recommended doses for seven days in order to study the effects of these antibiotics on human flora. Saliva and faecal specimens were collected for up to 29 days after administration of the antibiotics. Erythromycin caused only minor changes in the saliva flora while the aerobic and anaerobic colon flora were considerably disturbed. Clindamycin depressed both the anaerobic saliva and colon flora. Both erythromycin and clindamycin induced new colonization of the oral cavity and colon. The levels of free volatile fatty acids sank in saliva and faeces when erythromycin and clindamycin were given. The ecological disturbances caused by antibiotics require further investigation and should be taken into consideration in therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02014139
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