ISSN:
0170-2041
Keywords:
Inthomycins
;
Metabolites, secondary
;
Streptomyces sp.
;
Oxazole-triene
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Secondary Metabolites by Chemical Screening, 161). - Inthomycins, New Oxazole-Trienes from Streptomyces sp.The oxazole-triene metabolites inthomycin A to C (2, 4, 6) have been discovered by chemical screening in the culture broth of Streptomyces sp. (strain Gö 2). Its separation was successful only when the compounds had previously been transformed into the 3-O-(S)-2-phenylbutanoates 3, 5 and 7. The structures were deduced from their spectroscopic data, especially those taken from 2D-NMR spectra. The natural products reveal differences in the (E/Z) configuration of its triene chains. By feeding [1-13C]acetate to growing cultures of strain Gö 2, it was determined that C-1 to C-10 of the inthomycins biosynthetically originated via the polyketide pathway. Inthomycin A (2) has already been known as a substructure element of oxazolomycin (1) and probably is identical with the recently described phthoxazolin.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199119910164
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