Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Left heart function in chronic obstructive lung disease (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 433-441 
    Details
    ISSN: 1432-1440
    Keywords: Chronic obstructive pulmonary disease ; Left heart function ; Arterial hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In patients with varying degrees of chronic obstructive pulmonary disease (COPD), simultaneous measurements of central hemodynamics and left ventricular radionuclide ventriculograms at rest and during exercise were made. In 21 of these patients, satisfactory echocardiograms could be performed. In seven of the patients, arterial blood pressure at rest was increased. Decreased compliance of the left ventricle was thought to be present in patients with COPD and additional arterial hypertension. The left ventricular ejection fraction (LVEF) at rest was in the high normal range in all patients. During exercise, no further increase was observed. This pattern of LVEF response seems to be typical in patients with COPD. Because the highest values were observed in the more severe COPD and right ventricular hypertrophy, it is unlikely that an impairment of left ventricular function is caused by COPD. In five of 27 patients, an abnormal decrease of LVEF and regional hypokinesis occurred during exercise, thus suggesting additional coronary heart disease. The fact that at least 30% of the patients with COPD suffered from arterial hypertension and 20% of the patients exhibited unexpected ischemia detected by regional hypokinesis in RNV during exercise, but not in the ECG, may be of practical relevance. Coronary angiography was not indicated because most of these patients were over 65 and the factor limiting the working capacity was ventilatory impairment and not angina pectoris, in all patients. For this reason, a diagnostic uncertainty remains with regard to additional coronary heart disease in the older patients with advanced chronic obstructive pulmonary disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727529
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Radionuclide ventriculography and hemodynamic evaluation by right heart catheterization with exercise for assessing the functional significance of coronary artery stenoses (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 571-575 
    Details
    ISSN: 1432-1440
    Keywords: Myocardial ischemia ; Coronary artery disease ; Radionuclide ventriculography ; Right heart catheterization with exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A series of 13 patients with significant coronary stenoses but without prior myocardial infarction were simultaneously studied by right heart catheterization and radionuclide ventriculography to determine the extent to which abnormal responses in left ventricular ejection fraction and wall motion to maximum exercise are paralleled by abnormal left ventricular filling pressures. The correlations of the filling pressure as evaluated by the diastolic pulmonary artery pressure with both the exercise ejection fraction and the rest-to-exercise change in ejection fraction were high (r=−0.89,P〈0.01 andr=−0.76,P〈0.01, respectively). In addition, the filling-pressure response to stress separated the patients into distinct radionuclide categories. All the 7 patients with grossly abnormal filling pressures (P≥30 mmHg) developed regional wall motion abnormalities with exercise as evaluated by visual interpretation or quantitative phase analysis. These patients also had a decrease in ejection fraction from rest to exercise ranging from −9% to −32% together with an exercise ejection fraction below 50%. Conversely, these abnormalities were never found in patients with filling pressures below this threshold level. The data suggest that radionuclide ventriculography and measurement of left ventricular filling pressure with exercise yield corresponding results when assessing the functional significance of coronary stenoses in normotensive patients without prior myocardial infarction and normal global left ventricular function at rest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727625
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The schilling test cannot be replaced by an absorption test with unlabeled vitamin B12 (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 332-336 
    Details
    ISSN: 1432-1440
    Keywords: Vitamin B12 ; Vitamin B12 absorption ; Schilling test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It was the purpose of this study to evaluate the diagnostic usefulness of an oral absorption test using nonlabeled Vit B12 suggested by a commercial distributor as an alternative for the more expensive Schilling test (ST). Plasma levels of Vit B12 were measured with a commercial kit before and 4 h after oral administration of 1 mg Vit B12 in 32 normals, in 16 patients with normal ST, and in 14 patients with abnormal ST for determination of sensitivity and specificity with the ST as golden standard. In normals, a mean of 767±404 pg/ml before and 1096±776 pg/ml after oral Vit B12 with a mean increase of 331±453 pg/ml was measured. Because of the obvious large variation, no meaningful range for normal absorption could be established. In the two patient subsets, there was no Gaussian distribution of the results, with a meridian of Vit B12 increase after absorption of 142 pg/ml, range 27–2668 pg/ml, in the group with normal ST and a meridian of 244 pg/ml ranging from 40 to 2453 pg/ml in the group with abnormal ST. Statistical nonparametric analysis did not reveal any difference between the two groups. Assuming a minimum required increase of 100 pg/ml, as suggested by the kit distributor, a sensitivity of only 27% and a specificity of 75% was obtained. The lack of any diagnostic value of this approach might be caused by the known nonintrinsic-factor mediated absorption of approximately 1% of any B12 given orally even in complete intrinsic factor deficiency and by the relatively large amount of oral Vit B12 needed for a “cold” absorption test. The latter can, thus, not replace the Schilling test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01735789
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1985)
    Springer
    OR spectrum 7 (1985), S. 252-254 
    Details
    ISSN: 1436-6304
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01720182
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Right ventricular function in patients with chronic obstructive pulmonary disease (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 1041-1047 
    Details
    ISSN: 1432-1440
    Keywords: Chronic bronchitis ; Right heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Simultaneous right heart catheterization and radionuclide ventriculography were performed in 27 patients with a wide range of chronic obstructive pulmonary disease. Central hemodynamics and radionuclide studies were done at rest and during exercise. In the resting state the right ventricular ejection fraction (RVEF) was in the normal range (43.3±6%). During exercise a significant (p〈0.001) decrease of RVEF to 38.8±6.7% occurred. The pumonary artery mean pressures were 19.9±3.8 at rest. During exercise a significant (p〈0.001) increase to 41±9.8 mm Hg occurred. There was a linear relationship between pulmonary pressures and RVEF during exercise in patients with pulmonary artery pressures not exceeding 35 mm Hg. In patients with right ventricular end-diastolic wall thickness ≧6 mm a curvilinear relationship between these parameters could be observed with a flattening of the curve at higher pressures (〉35 mm Hg) and lower ejection fractions (〈35% RVEF). Radionuclide venticulography cannot substitute for right heart catheterization. Echocardiography is useful for interpretation of right ventricular ejection fractions in advanced chronic obstructive pulmonary disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01739670
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    DNA ploidy and protein synthesis in squamous cell carcinoma cell lines of the head and neck (1997)
    Springer
    Journal of cancer research and clinical oncology 123 (1997), S. 39-44 
    Details
    ISSN: 1432-1335
    Keywords: DNA content ; Squamous cell carcinoma ; Cell line ; Protein synthesis ; Head and neck
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aneuploidy, as abnormal nuclear DNA content, is considered almost positive evidence of malignancy. In this study three diploid and three aneuploid squamous cell carcinoma (SCC) cell lines were examined for DNA content by flow cytometry. The DNA indices of the SCC cell lines were found to range from 1.0 to 2.1. The mitotic activity of the diploid cell lines was 1.6 times higher and the cells were smaller than aneuploid cells. To find a molecular basis for these differences, the pattern of the de-novo synthesized proteins was analyzed by means of [35S]methionine incorporation, electrophoresis, and autoradiography. In all aneuploid SCC cell lines tested in this experiment, the increase of nuclear DNA content is associated with the synthesis of a novel protein with a molecular mass of approximate 55 kDa as well as with altered synthesis rates of two preexisting proteins (50 kDa and 100 kDa). For determination of the amino acid uptake in diploid and aneuploid cells, the accumulation of [35S]methionine was measured as a function of time by liquid scintillation counting. No significant difference was found in the uptake rate between diploid and aneuploid cells with the same protein content. However, discrepancies were revealed when equal numbers of cells with different DNA index were used, suggesting, that protein turnover is different in diploid and aneuploid SCC cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01212613
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Tumor scintigraphy with 131I anti CEA monoclonal antibodies and F(ab′)2 in colorectal cancer (1987)
    Springer
    European journal of nuclear medicine 13 (1987), S. 125-129 
    Details
    ISSN: 1619-7089
    Keywords: Tumor scintigraphy ; CEA monoclonal antibodies ; Colorectal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 14 patients with proven local recurrence of colorectal cancer or metastases in liver and/or lungs, the sensitivity (SE) in detecting tumor sites was estimated in a single-blind study using conventional planar whole body scintigraphy. Nine patients received F(ab′)2 and five received MAB by intravenous infusion over 30 min with a dose of 40–200 MBq after skin testing and thyroid blocking, scanning was performed 1–7 days later. All but one patient had elevated plasma CEA levels with a mean of 25.5±31.9 ng/ml. The scans were interpreted by two independent observers. In five of the nine patients receiving F(ab′)2, the tumor site could be visualized, yielding a sensitivity of 55%. No tumor sites were identified with MAB. The highest tumor uptake was recorded in a patient with additional ovarian cancer with the activity accumulating in the ovarian cancer. The optimum time for imaging was 3 or 4 days after injection. There was no correlation between positive imaging and plasma CEA levels which ranged from 1.9 ng/ml to 100 ng/ml in the positive cases. The thyroid uptake on the sixth day was 0.68%±0.2% of the total dose given despite thyroid blocking. Bone uptake of 131I was also observed, this was mild in four patients, moderate in three but high in one patient, especially on days one to four. Thus, only anti-CEA F(ab′)2 seem to be of clinical interest for further evaluation in localizing colorectal cancer. Regarding the still low sensitivity of 55%, further improvement can be expected by gaining experience, using more appropriate isotopes such as 111In and SPECT. The estimated radiation side effects on thyroid and bone marrow are only modest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00289023
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    The contraction fraction (CF) in myocardial studies with Technetium-99m-isonitril (MIBI) — correlations with radionuclide ventriculography and infarct size measured by SPECT (1989)
    Springer
    European journal of nuclear medicine 15 (1989), S. 661-664 
    Details
    ISSN: 1619-7089
    Keywords: Contraction fraction ; 99mTc-MIBI ; SPECT ; Myocardial size ; Radionuclide ventriculography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Criteria for the detection of coronary artery disease in nuclear cardiology include visualization of perfusion defects and functional impairment of contraction. The purpose of this study is to combine both methods in one procedure with the new myocardial perfusion tracer, 99mTc-methoxy-isobutyl-isonitril (MIBI), reducing time and radiation burden to the patient. Following an uncomplicated recovery, ten patients with first myocardial infarction participated in this study. Radionuclide ventriculography (RNV) was performed at rest and during exercise. Within 2–3 days, 370 MBq 99mTc-MIBI were injected and SPECT acquisition commenced 1 h later. Data processing included a scar image in polar coordinates. Areas of significantly reduced tracer uptake were expressed as a percentage of the total myocardial area. Directly following SPECT, resting and maximum exercise gated planar LAO images were recorded and the contraction was quantified. The concept of the contraction fraction (CF) rested on the end systolic change in count distribution: their increase in density and their centripetal concentration. For comparison, geometrical inner edge detection techniques were also applied. All algorithms for describing an EF equivalent were verified by computer simulations, showing a perfect correlation over a wide range of preset EFs. When applied to the patient studies only the non geometric methods revealed a good correlation with the ejection fraction (EF) obtained by RNV, and with the infarct size measured by SPECT. The corresponding correlation coefficients (r), standard errors (SEE) and the regression lines read as follows (in %): CF=0.56×EF+24.8; r=0.87; SEE=4.98; CF=-0.53×SPECT+71.5; r=0.93; SEE=4.19. Thus, estimation of the left ventricular function by the above defined CF is feasible, easy to perform and clinically meaningful. In one procedure with 99mTc-labelled MIBI not only the perfusion abnormalities were detectable, but also any reduction in function by a valied EF equivalent. Although the monochromatic gamma spectrum of the radionuclide provided better tissue penetrating power, the inner edge of the left ventricle was poorly outlined (especially in the stress studies) and does not lend itself to clinical routine practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251680
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Radionuclide ventriculography (equilibrium gated blood pool scanning) —its present clinical position and recent development (1988)
    Springer
    European journal of nuclear medicine 13 (1988), S. 637-647 
    Details
    ISSN: 1619-7089
    Keywords: Radionuclide ventriculography ; Myocardial scanning ; Functional imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Myocardial scanning (MS) and radionuclide ventriculography (RNV) are the foundation of nuclear cardiology. These procedures aim in two completely different directions: RNV tries to image heart motion, that is, mechanical (pump) function, and therefore belongs to the group of first-order functional imaging (FI, imaging mechanical function), whereas MS is based on myocardial metabolism, and therefore can be attributed to third-order functional imaging (metabolism). This statement is relevant for the assessment of the clinical position of RNV: Third-order (metabolism) functional imaging is the domain of nuclear medicine (NM), whereas first-order FI has to face the competition of alternative noninvasive procedures such as ultrasound (US), digital subtraction angiography (DSA), computer tomography (CT), and nuclear magnetic resonance (NMR). The domain of RNV includes stages two (acute infarction) and three (postinfarction period) of coronary arterial disease (CAD). The advantageous combination of quantitative data on global, left ventricular (LV) function and imaging of regional motion ensures the superiority of RNV over US. However, RNV is inferior to MS in physical examinations in the preinfarction stage of CAD, whereas US is clearly inferior to both NM procedures. Recent progress could be attained by gated SPECT (GASPECT). A proposal is presented for simplification of this time-consuming procedure. Technetium-labeled isonitriles offer the chance for the combination of “perfusion-motion” imaging of the myocardium. However, even standard RNV offers new possibilities. The multitude of parameters produced by quantitation has not yet been exploited completely. This can be done by discriminant analysis. The computer finds out an optimal subset from the whole set of parameters for the solution of a significant clinical problem. The software “learns” to find the “label” of a special pathognomonic entity. This computer work is supported by a relational data bank (Oracle) and an optical disk. Two examples for the effectiveness of the computer in problem solving are presented. It is concluded that RNV, even in the very competitive class of first-order functional imaging, enjoys a preferred position. The future indeed seems brighter because labeled isonitriles offer the chance for the combination of perfusion-motion imaging of the myocardium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256391
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Localization of enteral protein loss by 99m-technetium-albumin-scintigraphy (1989)
    Springer
    European journal of nuclear medicine 15 (1989), S. 217-218 
    Details
    ISSN: 1619-7089
    Keywords: 99mTc-Albumin-scintigraphy ; Constrictive pericarditis ; Enteral protein loss ; Gordon test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using 99mTc-Albumin scintigraphy in a patient with constrictive pericarditis and a highly positive Gordon test (35% albumin elimination in 5 days), it was possible to localize the protein loss in the small bowel for planning surgical treatment. Tc-HSA imaging is an easy method for qualitative investigation of protein losing enteropathy in the bowel. This technique is not as time consuming and cumbersome as the Gordon test and, in addition, allows the exact localization of protein loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253799
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...