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  • 1
    Electronic Resource
    Electronic Resource
    Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: Lessons from transgenic animal models
    Amsterdam : Elsevier
    Mechanisms of Ageing and Development 68 (1993), S. 71-87 
    Details
    ISSN: 0047-6374
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0047-6374(93)90141-D
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  • 2
    Electronic Resource
    Electronic Resource
    Sphaerospora tincae Plehn, 1925 in tench, Tinca tinca L., fry (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 8 (1985), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. The occurrence of Sphaerospora tincae Plehn, 1925 from tench in pond farms from northern and southern Germany is reported. The parasites form large masses in the anterior part of the body displacing the head kidney. They seem to be host specific for tench and are not found in the excretory part of the kidney. Mortalities caused by rupture of the abdomen may reach 100%, but usually appear to be low.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1985.tb00944.x
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of osteoclasts and their differentiation from mononuclear phagocytes by enzyme histochemistry (1987)
    Springer
    Histochemistry and cell biology 86 (1987), S. 225-227 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A double staining method is presented which allows the enzyme histochemical differentiation between osteoclasts (mono- and multinucleated forms) and mononuclear phagocytes (macrophages, multinucleated inflammatory giant cells). Osteoclasts are characterized by a strong acid phosphatase activity whereas macrophages and inflammatory giant cells show a variable non-specific esterase activity. The described method may be useful in studying the osteoclast origin and the extraosseus distribution of these cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00490251
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  • 4
    Electronic Resource
    Electronic Resource
    Postembedding immunohistochemical demonstration of antigen in experimental polyarthritis using plastic embedded whole joints (1981)
    Springer
    Histochemistry and cell biology 73 (1981), S. 439-446 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A method is presented for the immunohistochemical demonstration of antigens in whole undecalcified joints of small laboratory animals. With this method of tissue preparation, involving embedding in a medium mainly based on 2-hydroxyethyl methacrylate, preservation of antigenicity is satisfactory. Antigens can be demonstrated in 2 μm sections by either immunofluorescence or immunoperoxidase and an indirect technique. Therefore in addition to the morphological analysis of joint alterations in experimental polyarthritis, there is now an opportunity to trace the inciting antigen and to study in parallel the enzymatic equipment of the cells involved, using consecutive sections from a single block of tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00495658
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  • 5
    Electronic Resource
    Electronic Resource
    Borderline-tissues as sites of antigen deposition and persistence — a unifying concept of rheumatoid inflammation? (1985)
    Springer
    Rheumatology international 5 (1985), S. 221-227 
    Details
    ISSN: 1437-160X
    Keywords: Antigen distribution ; Experimental chronic polyarthritis ; Rheumatoid organs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In organs of rheumatoid inflammation avascular tissue is nourished by perfusion either directly from the blood stream or by neighbouring blood vessels (borderline-tissue). An open question remains whether this borderline-tissue promotes only the known antigen persistence, or also the first deposition of the pathogenetically important microbial antigen, and subsequently a deposition of immune complexes. The three markers (carbon, latex, and living bacteria) used in this study led to nearly the same pattern of deposition in two groups of organ systems: (1) Organs with clearance function belonging to the mononuclear phagocyte system (MPS); (2) organs with borderline-tissues: joint, kidney, artery, heart valve, and eye. This deposition at the borderline can be observed best in areas of the joint where highly vascularized tissues are adjacent to avascular tissues nourished via perfusion: (1) perichondrium, (2) peritendineum, (3) periosteum, and (4) endo- and perimysium. These localisations of particle deposition correspond exactly with the intraarticular predilection sites of chronic rheumatoid inflammation in man and animals. Our results indicate an easier settlement of corpuscular material in these localisations, which at the same time are unable to eliminate such substances, unlike the organs of the MPS. Our studies seem to support the theory of pathogenetic importance of the borderline-tissues as a localizing factor in the perpetuating rheumatoid inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541340
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  • 6
    Electronic Resource
    Electronic Resource
    Idiopathic Myelofibrosis in a Cat and in Three Dogs (1999)
    Springer
    Comparative clinical pathology 9 (1999), S. 17-24 
    Details
    ISSN: 1433-2981
    Keywords: Key words:Agnogenic myeloid metaplasia – Bone marrow – Chronic myeloproliferative disorder – Enzyme histochemistry – Idiopathic myelofibrosis – Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Idiopathic myelofibrosis (IMF) in an 8-year-old cat and in three dogs, aged 4, 8 and 3 years, respectively, is discussed. Haematologically, the prefibrotic IMF of the FeLV (feline leukaemia virus)-positive cat exhibited an aleukaemic pattern of development with thrombocytosis; gross-pathologically, it exhibited a splenomegaly, and histologically, abnormal (polymorphic) medullary megakaryocytopoiesis and increased neutrophilic granulocytopoiesis with neoplastic bilinear extramedullary haematopoiesis (myeloid metaplasia, MM) in the spleen and liver. Haematologically, the canine IMFs exhibited anaemia, with white blood cell values ranging between leucocytosis and leucopenia, and thrombocyte values from the normal range to thrombocytopenia. Gross-pathologically, they exhibited hepatosplenomegaly, and histologically, a medullary proliferation of abnormal (polymorphic) megakaryocytes with conspicuous concentration in clusters, reticulin fibrosis and, in two cases, the occurrence of distended sinusoids with intravascular haematopoiesis. Extramedullary neoplastic haematopoiesis (MM) was found in the spleen and liver in particular. From the differential diagnostic perspective, the following morphological criteria are particularly relevant: largely mature, polymorphic megakaryocytes, distended bone marrow sinusoids, only a small number of blast cells in the bone marrow, MM of the spleen and liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010002
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