Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Transcranial stimulation of the human frontal eye field by magnetic pulses (1991)
    Springer
    Experimental brain research 86 (1991), S. 219-223 
    Details
    ISSN: 1432-1106
    Keywords: Magnetic stimulation ; Cortical stimulation ; Frontal eye field ; Eye saccades ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Single transcranial magnetic pulsed stimuli were applied over the cortical area of the putative right frontal eye field (FEF) in 11 healthy subjects. An especially designed figure of eight shaped twin coil was used, to focus the stimulus, the strength of which was adjusted to the individual motor threshold of the left hand muscles. Eye positions and movements were recorded by an infrared reflection technique. Three different experiments were performed: 1. Stimulation during different primary gaze position did not evoke any discernible eye movement. 2. Stimulation just prior to visually elicited horizontal saccades did not cause a significant alteration of the latency, velocity, or amplitude of the saccades. 3. Only stimulation during an antisaccade task induced a significant latency prolongation, when the stimulus was applied between 50 to 90 ms after the target flashed up. This latency prolongation was found in all subjects for the antisaccades to the right, with a statistically significant average latency difference of +66 ±55.5 ms. In contrast, the antisaccades to the left were prolonged in the female subjects only by an average of + 98 ± 41.8 ms (p=0.0064), whereas in the male subjects they did not alter with stimulation (average difference: -3 ±41.9ms, p=0.753). Significant latency prolongations were only obtained when the magnetic FEF stimuli were applied within a vulnerable period, which varied from subject to subject.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00231057
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Influence of transcranial magnetic stimulation on the execution of memorised sequences of saccades in man (1994)
    Springer
    Experimental brain research 101 (1994), S. 521-524 
    Details
    ISSN: 1432-1106
    Keywords: Eye movements ; Saccades ; Supplementary motor area ; Memory ; Transcranial magnetic stimulation ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Memorised sequences of saccades are cortically controlled by the supplementary motor area (SMA), as shown in animal experiments and in humans with isolated SMA lesions. We applied transcranial magnetic stimulation (TMS) in eight healthy subjects executing memorised sequences of saccades. Sequences of three targets were presented. Then, upon a go-signal, the subjects had to execute the appropriate sequences. Ten to fifteen sequences were performed in each experiment, and the number of errors were counted. The number of errors increased significantly if TMS was given 80 ms before or 60 ms after the go-signal, with the stimulation coil overlying the SMA. There was no significant increase in errors if different stimulation intervals were chosen (160ms and 120ms before the go-signal; 100 ms, 140 ms or 240 ms after the go-signal), if the coil was positioned inappropriately (e.g. over the occipital cortex), or if the stimulator output was too low. We conclude that TMS can interfere specifically with the function of the SMA during a critical time interval close to the go-signal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227345
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Auditory brain-stem potentials studied with paired stimuli in normals (1987)
    Springer
    Journal of neurology 234 (1987), S. 298-302 
    Details
    ISSN: 1432-1459
    Keywords: Evoked potentials ; BAEP ; Paired stimuli ; Refractoriness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Brain-stem auditory evoked potentials (BAEPs) to paired stimuli of various intervals were recorded using a subtraction technique to cancel the first and facilitate recognition of the second response. In a pilot series of 12 experiments, no latency change was encountered with paired click intervals (PCI) of 8 and 6 ms. Thirty healthy subjects were then investigated by presenting single and paired stimuli with a PCI of 4, 3.1, 2.3 and 1.5 ms at a repetition rate of 10/s to each subject. With diminishing PCIs, identification and latency measurement of waves IV and V became increasingly difficult because of marked amplitude reduction. Component III remained identifiable in all but two recordings and showed a statistically significant latency increase and amplitude reduction only when the stimuli were presented 1.5 ms apart. Component I did not show a consistent latency change with any PCI but its amplitude was significantly reduced with 4 ms PCI. These findings differ from those reported when using PCIs of 5 ms or more and when using single stimuli at a high repetition rate, where component V was the most stable. The alterations of evoked potentials found only with a PCI of 1.5 ms are probably of central origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314284
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Thalidomide-induced peripheral neuropathy (1986)
    Springer
    Journal of neurology 233 (1986), S. 83-89 
    Details
    ISSN: 1432-1459
    Keywords: Thalidomide-induced neuropathy ; Electroneurography ; Pharmacogenetic classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Prospective clinical and electrophysiological follow-up was performed on nine patients under thalidomide treatment in order to detect the very beginning of possible drug-induced peripheral neuropathy. For neurophysiological assessment, nerve conduction measurements of the median, peroneal and sural nerves (7 conduction parameters) and needle EMG examination of the anterior tibial muscle were performed. The results of a first control after about 3 months of treatment were compared with the starting point examination, and the patients were then classified as “affected” or “not affected” according to clinical and neurophysiological criteria. At this point, three patients showed clinical and electrophysiological, and another two only electrophysiological alterations suggesting early neuropathy. This classification did not change after further clinical and electrophysiological controls. Without starting-point values, the early detection of neuropathy would not have been possible in all patients. No single reliable neurophysiological parameter for detection of thalidomide-induced neuropathy could be found. Pharmacogenetic classification with regard to hydroxylation and acetylation phenotypes was then performed in some patients and interpreted with relation to thalidomide neurotoxicity. A possible relationship between slow acetylators and development of thalidomide-induced neuropathy was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313852
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Encephalopathy associated with Hashimoto thyroiditis: Diagnosis and treatment (1996)
    Springer
    Journal of neurology 243 (1996), S. 585-593 
    Details
    ISSN: 1432-1459
    Keywords: Hashimoto thyroiditis ; Encephalopathy ; Antithyroid autoantibodies ; Autoimmune disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Six patients with Hashimoto thyroiditis (HT) and associated encephalopathy (HE) are described and compared with 14 well-documented cases retrieved from the literature. HE typically affects patients when they are euthyroid and, in an appropriate clinical situation, antithyroid autoantibodies are the main indicators of HE. Since clinical features of HE are unspecific, other aetiologies such as infectious, metabolic, toxic, vascular, neoplastic, and paraneoplastic causes have to be excluded. Our own six cases and those from the literature show that two types of initial clinical presentation can be differentiated: a vasculitic type with stroke-like episodes and mild cognitive impairment in nine patients, and a diffuse progressive type with dementia, seizures, psychotic episodes or altered consciousness in 11 patients. These types may overlap, particularly in the long-term course without treatment. Response to steroids was usually excellent with complete remission in 80%. Eighteen of the 20 patients were women. Characteristic, though unspecific, findings were abnormal EEG (90%) and CSF (80%). Together with quantitative neuropsychological testing, these proved sensitive for monitoring the efficacy of therapy. Conversely, antithyroid autoantibody titres did not correlate with the severity or type of clinical presentation. The link between HE and HT is not clear. A pathogenetic role for antithyroid autoantibodies in the central nervous system seems unlikely.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00900946
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    An intelligent space robot for crew help and crew and equipment retrieval (1995)
    Springer
    Applied intelligence 5 (1995), S. 7-39 
    Details
    ISSN: 1573-7497
    Keywords: real time ; vision ; manipulators ; mobility ; reacting ; planning ; grasping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract This paper describes the development status of a prototype supervised intelligent robot for space application for purposes of (1) helping the crew of a spacecraft such as the Space Station with various tasks such as holding objects and retrieving/replacing tools and other objects from/into storage, and for purposes of (2) retrieving detached objects, such as equipment or crew, that have become separated from their spacecraft. In addition to this set of tasks in this low Earth orbiting spacecraft environment, it is argued that certain aspects of the technology can be viewed as generic in approach, thereby offering insight into intelligent robots for other tasks and environments. Some candidate requirements for the space applications are presented which will be refined by the results of the prototype development and evaluation testing. Our development approach is described, including space simulation environments used in developmental testing. Candidate software architectures and their key technical issues which enable real work in real environments to be accomplished safely and robustly are addressed. Results of computer simulations of retrieving detached objects, including the situated reasoning/reaction plan approach used, are presented, as well as the results of an air bearing floor simulation of retrieving detached objects. Also described are characterization results on the usable reduced gravity environment in an aircraft flying parabolas (to simulate weightlessness) and results on hardware performance there. These results show it is feasible to use that environment for evaluative testing of dexterous grasping based on real-time vision of freely rotating and translating objects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00872781
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Okuläre Myositis (1997)
    Springer
    Der Nervenarzt 68 (1997), S. 792-800 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Okuläre Myositis ; Orbitale Myositis ; Vergrößerung ; Extraokulärer Augenmuskeln ; Orbitale Kernspintomographie ; Orbitale Computertomographie ; Key words Ocular myositis ; Orbital myositis ; Enlarged extraocular muscles ; Magnetic resonance imaging ; Computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report a young woman presenting with „painful diplopia” caused by inflammation of external eye muscles affecting both eyes sequentially. Orbital MRI disclosed swelling, signal hyperintensity and enhancement of isolated eye muscles. Corticosteroid treatment led to a complete remission within a few days. The compiled data of a literature review enclosing 52 sufficiently documented patients diagnosed as orbital myositis is reported with respect to clinical features, laboratory findings, associated disease, value of imaging procedures (CT, MRI). Therapeutic aspects and differential diagnosis are reviewed.
    Notes: Zusammenfassung Eine junge Patientin mit subakuter schmerzhafter Diplopie als Folge von entzündlichen Veränderungen der äußeren Augenmuskeln, die sequentiell beide Augen betrafen, wird vorgestellt. Das orbitale Kernspintomogramm zeigte eine Schwellung, Signalhyperintensität und Kontrastmittelanreicherung einzelner Augenmuskeln. Die Behandlung mit Kortikosteroiden führte zu einer vollständigen Remission der Symptomatik innerhalb weniger Tage. Aufgrund der Daten von insgesamt 52 gut dokumentierten Patienten mit okulärer Myositis aus der Literatur stellen bewegungsabhängige retrobulbäre Schmerzen (94%) mit Diplopie (85%) die Kernsymptome des Krankheitsbildes dar. Ein weiterer klinischer Hauptbefund ist die konjunktivale Injektion (73%), meistens an der Insertionsstelle des betroffenen Muskels. Die exophthalmische Form mit zusätzlichem Lidödem, Ptose, Chemose und Exophthalmus tritt seltener auf (24%), eine Visusabnahme ist die Ausnahme. Ein beidseitiger Augenmuskelbefall, typischerweise sequentiell, wird in 40% beobachtet. Frauen sind häufiger betroffen (73%), das mittlere Erkrankungsalter liegt bei 34 Jahren. Der M. rectus medialis ist der am häufigsten betroffene Muskel (70%). Die Diagnosesicherung gelingt heute mit der Kernspintomographie auch in leichteren Fällen. Der durch die Entzündung erhöhte Wassergehalt der befallenen Muskeln erklärt die gegenüber der Computertomographie erhöhte Sensitivität der Kernspintomographie. Therapie der Wahl ist die Behandlung mit Kortikosteroiden, hierunter kommt es in 90% innerhalb von Tagen zur Abheilung. Bei zu kurzer Therapiedauer sind Rezidive häufig. Bei Therapieresistenz ist die niedrigdosierte Bestrahlung meist effizient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050196
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...