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  • 1
    Electronic Resource
    Electronic Resource
    Striatal ganglioside levels in the rat following kainic acid lesions: Comparison with Huntington's disease (1981)
    Springer
    Experimental brain research 44 (1981), S. 93-96 
    Details
    ISSN: 1432-1106
    Keywords: Gangliosides ; Striatum ; Kainic acid lesion ; Huntington's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ganglioside and DNA levels were estimated in the striatum of rats 10 days and 6 weeks after lesioning by intrastriatal injection of kainic acid. There was a moderate, 21–24% decrease of the ganglioside concentration per unit protein on the side of the lesion, which can be ascribed to the loss of the intrinsic striatal neurons following the injection of kainic acid. On the other hand, there was a 131 and 60% increase of DNA per unit protein in the kainate injected side 10 days and 6 weeks after the lesions, respectively; these changes apparently reflected the gliotic reaction brought about by the neurotoxin. Qualitatively similar findings — a decrease of ganglioside and an increase of DNA levels per unit protein — were also found in the brain of patients with Huntington's disease; however, as compared with the corresponding control material, the decrease of the ganglioside concentration was more pronounced in the striatum of Huntington's disease (by 38% in the caudate nucleus and by 46% in the putamen) than in the kainate lesioned rat striatum. This difference could be due to the different proportions of the intrinsic and extrinsic neuronal plasma membranes in the striatum of the two species; however, the possibility of a more generalized affection of neuronal plasma membranes in Huntington's disease may also be envisaged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238752
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Gangliosides in rabbit and human skeletal muscle with denervation atrophy (1984)
    Springer
    Journal of neurology 231 (1984), S. 79-82 
    Details
    ISSN: 1432-1459
    Keywords: Gangliosides ; Denervation atrophy ; Skeletal muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer Publikation wurde berichtet, daß es nach experimenteller Denervierung des Kaninchenskelettmuskels zu einem Anstieg der Gangliosidkonzentration komme. Wir untersuchten Gangliosid-, DNS-, Gesamtlipidund Proteinkonzentrationen bei experimenteller Denervierung des Musculus gastrocnemius des Kaninchens und bei neurogener Atrophie des menschlichen Skelettmuskels. Bei schwerer neurogener Atrophie kam es zu einer statistisch signifikanten Zunahme der Gesamtgangliosid-, DNS-und Gesamtlipidkonzentration, während die Proteinkonzentration im Vergleich zu den Kontrollen signifikant abnahm. Das Gangliosidmuster bei schwerer neurogener Atrophie zeigte signifikante Zunahme eines GT1b-ähnlichen bzw. eine relativ deutliche Abnahme eines GM1-ähnlichen Gangliosids. Die Untersuchungen bei experimenteller Denervierung des Kaninchenskelettmuskels brachten ähnliche Ergebnisse wie bei der neurogenen Atrophie des Menschen: signifikante Zunahme der Gesamtgangliosidkonzentration, Zunahme des GT1b-ähnlichen und signifikante Abnahme des GM1-ähnlichen Gangliosids.
    Notes: Summary In experimental denervation of rabbit skeletal muscle, an increase of gangliosides has been reported. Ganglioside, DNA, total lipid and protein levels were studied in experimental denervation of rabbit gastrocnemius muscle and in human skeletal muscle with denervation atrophy. In severe human denervation atrophy total ganglioside, DNA and total lipid levels were increased, and protein levels decreased as compared with controls. The ganglioside pattern was changed in severe human denervation atrophy and showed a significant increase of a GT1b-like and moderate decrease of a GM1-like compound. Findings in experimentally denervated rabbit muscle resembled results obtained in human denervation atrophy, showing a significant increase of total ganglioside levels as well as a moderate increase of GT1b-like and decrease of GM1-like compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313721
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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