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  • 1
    Electronic Resource
    Electronic Resource
    The quality of function of renal allografts is associated with donor age (1995)
    Springer
    Transplant international 8 (1995), S. 221-225 
    Details
    ISSN: 1432-2277
    Keywords: Donor age, renal function ; Kidney function, donor age ; Age donor, renal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The quality of renal allograft function was assessed by prospective measurement of creatinine clearance at 1 year (n=197) and at 3 years (n=115) after cadaveric renal transplantation in a cohort of 268 patients treated with triple therapy immunosuppression. Donor age (P〈0.0012) and recipient age (P〈0.01) were independently associated with creatinine clearance both at 1 and at 3 years. In patients with donor age above 50 years and recipient age above 45 years, the mean creatinine clearance was 32.7 (SD 10.4) ml/min (n=27). When the donor age was below 30 years and recipient age below 45 years, the mean creatinine clearance was 55.6 (SD 14.4) ml/min (n=47, P〈0.001). However, in these patients there was no significant association between graft function and many of the factors known to influence graft survival, such as HLA matching, sensitisation of the recipient, and the occurrence of rejection. In conclusion, the quality of renal allograft function declined with increasing donor and recipient age in our patients, whilst immunological factors were not significantly associated with function in surviving grafts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336541
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  • 2
    Electronic Resource
    Electronic Resource
    Antibody removal and subsequent transplantation of a highly sensitised paediatric renal patient (1996)
    Springer
    Transplant international 9 (1996), S. 155-160 
    Details
    ISSN: 1432-2277
    Keywords: Kidney transplantation, ensitisation, antibody removal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a successful renal transplant in a highly sensitised paediatric recipient following removal of HLA-specific antibodies by extracorporeal immunoadsorption. The immediate pretransplant cytotoxic titre against the donor was greater than 1:512; this was reduced to negativity by two immunoadsorption sessions prior to transplant surgery. We also describe the presence of unexpected non-HLA-specific antibody activities in this immunoadsorbed patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336394
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Antithymocyte globulin for steroid resistant rejection in renal transplant recipients immunosuppressed with triple therapy (1989)
    Springer
    Transplant international 2 (1989), S. 27-32 
    Details
    ISSN: 1432-2277
    Keywords: Antithymocyte globulin ; Triple therapy in kidney transplantation ; Immunosuppression ; Steroid-resistant rejection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Steroid resistant rejection, confirmed histologically, occurred in 35 of 187 consecutive cadaveric renal transplants treated with triple therapy (cyclosporin, azathioprine and prednisolone) in the Oxford Transplant Unit. Twenty-seven of these were treated with a rabbit antithymocyte globulin (ATG) and 19 showed recovery of function. The level of serum creatinine, the renal biopsy appearance and the requirement for dialysis at the start of ATG treatment did not predict which patients would respond to the therapy. One year after transplantation there was no significant difference between the mean plasma creatinine levels of those patients with steroid resistant rejection who had been given ATG and responded (151.6 μmol/l) and those who had responded to steroids alone (165.0 μmol/l). Adverse effects of ATG treatment included a mean fall in white cell count of 62.2% and a mean fall in platelet count of 45.1%. Two of the 27 patients who received ATG died (7.4% mortality). ATG would appear to be an effective treatment of steroid resistant rejection in patients receiving triple therapy immunosuppression, and graft function may subsequently be excellent in those patients who respond to treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02425968
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Triple therapy immunosuppression in cadaveric renal transplantation (1990)
    Springer
    Transplant international 3 (1990), S. 26-31 
    Details
    ISSN: 1432-2277
    Keywords: Immunosuppression, triple therapy, kidneys ; Cyclosporin, in triple therapy ; Azathioprine, in triple therapy ; Kidney transplantation, triple therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One hundred and ninety-two patients received 200 consecutive cadaver renal transplants (158 first and 42 regrafts) and were treated with triple therapy immunosuppression consisting of low-dose cyclosporin, azathioprine and prednisolone. One-year patient and graft survival rates were 95% and 82%, respectively. Against this low rate of graft loss, the proportion of rejection-free patients in the first 3 months was strongly related to matching for HLA-DR (P〈0.01), although HLA-DR matching was not associated with improved graft survival. More grafts were lost to nonimmunological causes than to rejection, and these losses fell into three main categories, namely, losses in elderly and diabetic patients and losses due to renal vascular thrombosis. Thus, triple therapy immunosuppression appears to offer effective immunosuppression, resulting in good graft and patient survival, especially in highly sensitised patients or patients receiving regrafts. There are relatively few serious adverse effects, although elderly and diabetic patients experienced significant morbidity and mortality after transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333199
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    Paper (German National Licenses)
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