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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Sensors and Actuators B: Chemical 20 (1994), S. 1-5 
    ISSN: 0925-4005
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Sensors and Actuators B: Chemical 19 (1994), S. 376-379 
    ISSN: 0925-4005
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1238
    Keywords: Key words Ventilator-associated pneumonia ; Microbial biofilm ; Antibiotic resistance ; Endotracheal tube ; Medical device
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To determine the relationship between, and antibiotic resistance of, endotracheal tube (ET) biofilm and pulmonary pathogens in ventilator-associated pneumonia (VAP).¶Setting: General intensive care units in two university teaching hospitals.¶Design: The microbiology of ET biofilm and tracheal samples from patients with and without VAP were compared. For individual patients, matching pairs of pathogens were confirmed as identical and characterised for antibiotic susceptibility.¶Patients: 40 intensive care unit patients – 20 with VAP, 20 without VAP as control. The duration of intubation (median and range) was 6.5 days (3–17) and 5 days (2–10), respectively.¶Measurements and results: Samples of tracheal secretions were taken during ventilation for bacteriological culture. Following extubation, ETs were examined for the presence of biofilm. Isolates of high pathogenic potential included Staphylococcus aureus, enterococci, Enterobacteriaceae, pseudomonads and Candida spp. Where the same microorganism was found on tracheal and ET samples by phenotyping, these were confirmed as identical by genotyping and characterised for antibiotic susceptibility in both the free floating and biofilm forms. Seventy per cent of patients with VAP had identical pathogens isolated from both ET biofilm and tracheal secretions. No pairing of pathogens was observed in control patients (p 〈 0.005). Susceptibility data for these pairs show that the ET acts as a reservoir for infecting microorganisms which exhibit significantly greater antibiotic resistance than their tracheal counterparts.¶Conclusion: This investigation provides further evidence for the role of ET biofilm in VAP. The difficulty in eradicating an established microbial biofilm using antibiotics implies that increased attention must be directed towards modification of the ET to prevent or substantially reduce biofilm formation.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1009
    Keywords: KEY WORDS: Russia; Siberia; Tomsk; Management; Radioactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The vein-type gold deposits of middle to late Archean age constitute one of the major sources of gold production in the world. These deposits are highly diverse in character, but are invariably found in proximity to mafic and ultramafic volcanic rocks, and closely associated with tectonically disturbed zones, or ‘breaks’, in the ancient crust. Using the Larder Lake ‘break’ of northern Ontario and Quebec as a model, a general theory of genesis for such deposits is proposed. The Larder Lake ‘break’ is of linear configuration, up to four miles wide, and extending over a distance of approximately 150 miles. Many rich and extensive vein-type gold deposits are associated with it. This ‘break’ is recognized as a highly folded and faulted, dominantly sedimentary stratigraphic unit, formed as part of the development of the Blake River geosyncline of the Abitibi greenstone belt. Faulting is pervasive within the ‘break’ but it is non-continuous. Under an oxygen-poor, somewhat acidic weathering regime believed extant in Archean time, gold and associated constituents, derived as weathering products from mafic and ultramafic volcanics, appear to have been concentrated as solutions and sols in muddy surficial accumulations along a paleo-continental margin. On transfer to a shallow marine environment, the gold-bearing solutions became concentrated mainly as cherty and pyritic evaporitic residues. These residues, infolded and variably metamorphosed and remobilized during ensuing geosynclinal development, formed the numerous and apparently heterogeneous gold deposits of the Larder Lake ‘break’. Mode of redistribution of gold-bearing residues and metamorphism of their host rocks varies widely. In mild form, little vein development is present and original sedimentary features of the host rock are often preserved. In more extreme cases, true hydrothermal veining is evident and complete recrystallization of the host rock has taken place, sometimes to the extent of formation of a melt with intrusive capabilities. In any case, the gold and related vein constituents remain closely associated with the primary host material and alteration effects are largely derived from the recrystallization of original host rock constituents. The suggested mode of genesis clarifies the relationship between various types of ‘break’-related, vein-type gold deposits and offers an explanation of the complex stratigraphy and structure of the ‘break’ environment. It also suggests a penecontemporaneous relationship between the Larder Lake ‘break’ and other auriferous ‘breaks’, of varying configuration, within the Superior Province of the Canadian Shield. The concept can be used advantageously in exploration for new ‘breaks’ and new deposits.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 804-809 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The interaction between imipenem and two glycopeptides against staphylococci was examined for potential synergy. Imipenem in combination with vancomycin or teicoplanin exerted a synergistic or additive effect against a majority ofStaphylococcus aureus andStaphylococcus epidermidis isolates tested by the checkerboard method. Synergistic inhibitory effects were frequently accompanied by synergistic bactericidal effects. For a proportion of bacterial isolates of both species, the demonstration of synergy by the checkerboard method was confirmed by time-kill studies using antibiotic combinations at the MICs or at achievable serum antibiotic levels. Only with a single isolate ofStaphylococcus epidermidis was antagonism with either antibiotic combination recorded.
    Type of Medium: Electronic Resource
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