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  • 1
    ISSN: 1435-2451
    Keywords: Selective Proximal Vagotomy and Pyloroplasty Insulinnegativity of S.p.V. ; Results after S.p.V. and Pyloroplasty in Symptomatology ; In X-Ray ; In Endoscopy ; In Secretionstests ; Lethality 0,68.% ; Function Good 89 % ; Satisfying 7 % ; Poor 1,03 % ; Recurrencies 0,68 %
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bericht über 732 Fälle von selektiver Vagotomie, die wegen Gastroduodenalulcus zwischen 1964–71 an der Universitäts-Poliklinik München operiert wurden. Der Prototyp einer s.p.V. ist die Fundektomie. Beobachtungen an Fundektomien seit 1954 haben klargemacht, daß über die extragastrale vagale Innervation sekretorische Reflexe zur Fundus-Corpusregion und motorische Reflexe zum Antrum übermittelt werden. Eine S. p. V. eliminiert erstere und erhält die Letzteren. Die Technik der S.p.V. muß insulinnegatives Verhalten herstellen. Beobachtungen von v. Yzeren, Dragstedt und aus der eigenen Klinik lassen die Kombination einer S.p.V. mit einer Pyloroplastik ratsam erscheinen. Auf dieser Basis wurde das System „form- und funktionsgerechter Operationen bei GDU” definiert (Holle, 1964). 590 Fälle von S.p.V. + Pyloroplastik (oder Minimalresektion) wurden einer näheren Nachuntersuchung unterzogen. Analysiert wurden dieIndikationen für diesen Eingriff. - Die prä- und postoperativeSymptomatologie wird gegenübergestellt. - Dumpingsyndrome sind mit 0,6 bis 2 % relativ gering. - Die prä- und postoperative Röntgenkontrolle macht die Nachteile einer Pylorektomie gegenüber einer Pyloroplastik deutlich. - Die Endoskopie beweist die aktive Funktion (Öffnung und Schlußfähigkeit) des Pylorus. Dazu muß ohne jede medikamentöse Beeinflussung untersucht werden. Die Reduktion der Säuresekretion und des Volumens wird mit Insulin - Pentagastrin - Totalgastrin getestet. Die Reduktion beträgt im Gastrintest 84,5 bis 90%; im Insulintest sind rund 92% insulinnegativ. 8 % bleiben frühpositiv, jedoch überschreitet die Restsekretion die 1.0 mEq-Grenze/h nicht. Der Wert der Blaufärbung nach LEE wird hervorgehoben. Letalität und funktionelle Resultate betragen für die S.p.V. + Pyloroplastik Letalität :0,68% Funktion gut: 89% befriedigend: 7% schlecht: 1,03% Rezidive: 0,68%. Der Bericht beweist, daß die Operationsmethode als kurative Maßnahme bei GDU brauchbar ist und die konventionelle Resektionsbehandlung -jedenfalls als Primärmaßnahme - zu ersetzen vermag.
    Notes: Summary Report of 732 consecutive cases of S.p.V. + Pyloroplasty operated from 1964–1971 at the Munich University Policlinic. The operation is based on the observation that two different reflex qualities are conveyed via the extragastric vagal innervation a) secretory ones to the fundus — corpus region, b) motorial ones to the antrum. S.p.V. eliminates the first and maintaines the latter. The technique of S.p.V. must bring about insulin-negative behaviour. Such an extensive S.p.V. must be combined with a drainage procedure. The survey is recording the indication, the clinical symptoms, the X-ray findings, the Endoscopy, the secretion of acid and volume (controlled with insulin and gastrin), before and after operation each group. Results: Elective lethality 0,68 %, overall lethality 2,2 % postoperative function good 89 % postoperative function satisfactory 7 % postoperative function poor 1,03 % recurrencies 0,68 %. The series shows that successful surgical treatment of GDU is possible without the conventional resection therapy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 802-803 
    ISSN: 1435-2451
    Keywords: Deterioration ; Duodenal ulcers ; Gastric ulcer ; Indications for early surgery ; Verschleppung ; Krankheitssymptome ; Ulcus duodeni und ventriculi
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der präop. Symptomenkatalog von 2264 vom Autor endoskopisch untersuchten peptischen Ulcuspatienten (incl. Röntgen, Szintigraphie, Sekretion, Histologie) wurde anhand von 4 Studien zwischen 1969 und 1983 vergleichend beurteilt. Epidemiologie: 4 J. früherer Krankheitsbeginn (Kb) für UD bei Zunahme der Krankheitsdauer (Kd) um 46% (jetzt 14,4 J ± 9,3), UV Kb 7 J. früher, Kd gleichbleibend. Beschwerdezunahme: Sodbrennen + 108%, Erbrechen + 96%, Blutungen: UD + 88%, UV + 200%. Zunahme der vitalen „peptischen” Ulcusblutungen +56%. Zunahme der Pylorusstenosen (mittel- und hochgradig) + 56 %, der Bulbusstenos. +245 %. Patientenzahl mit starker Entleerungsverzögerung (Röund Szinti.) um das 8fache gestiegen, usw. Die Indikation zur nichtresezierenden operativen Behandlung ist wesentlich frühzeitiger, d. h. vor Auftreten von Komplikationen zu stellen.
    Notes: Summary Between 1969 and 1983 2,264 patients suffering from peptic ulcer were examined preoperatively by endoscopy (performed by the author), radiology, scintiscanning and by secretion analysis, in four controlled studies. The results of the most recent examination period were compared with those from the early 1970s, and show the age of onset of the disease to be about 4 years earlier and a 46 increase in the preoperative duration of duodenal ulcer (DU). In gastric ulcer (GU), the disease begins now 7 years earlier, with no change in the preoperative duration. The number of patients suffering from heartburn has increased by 108 %, vomiting by 96 %, bleeding in DU by 88 % and bleeding in GU by 200%. Dangerous bleeding from peptic ulcer has increased by 56%. Serious pyloric stenosis has increased by 56 % and stenosis of the duodenal bulb by 245 %. The number of patients with severely delayed gastric emptying shown by X-ray and scintiscanning has increased about 8-fold. Earlier surgery is indicated, to prevent the onset of complications.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-2451
    Keywords: Duodenal ulcer ; Gastric ulcer ; Recurrences ; Deterioration in clinical picture ; Rezidivrate ; Ulcus duodeni ; Ulcus ventriculi ; Verschlechterung des klinischen Bildes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Untersuchungen: Endoskopie (Histologie), Röntgen, Szintigraphie, Säuresekretion, S. Gastrin, OP-Bericht. UD 1199 präop. 1018 (85%) SPV + Pypl. + Ulc.Exc. 43% postop. (10% prospect.). UV 421 präop. 315 (75%) SPV + Pypl. + Ulc.Exc. 39% postop. (23% prospect.). Rezidivrate kalkuliert in Relation zu postop. Untersuchten: UD: 6,3% (5,4% von UD nach UD; 0,9% von UD nach UV). UV: 8,l% (6,5% von UV nach UV; 0,8% von UV nach Ca). Mögliche Ursachen für Rezidiv: UD in 79%, UV in 90% technische Fehler (inadaequate Vagotomie, Motilitätsstörungen). UD 18%, UV 10% nicht erklärbar. Ansteigende Rezidivrate verursacht durch Verschlechterung im klinischen Bild in den letzten 17 Jahren.
    Notes: Summary The examinations carried out were: endoscopy (histology), radiology, scintigraphy, acid secretion, serum-gastrrn, operative report. There were 1199 duodenal ulcers (DU), diagnosed preoperatively. 1018 (85%) had SPV + pyloroplasty + ulcer excision. 43% of them were examined postoperatively (10% in a prospective study). There were 421 gastric ulcers (GU) diagnosed preoperatively. 315 (75%) underwent SPV + pyloroplasty + ulcer excision. 39% of them were examined postoperatively (23% in a prospective study). The recurrences were calculated in relation to the patients examined postoperatively. DU: 6.3% (5.4% from DU to DU; 0.9% from DU to GU). GU: 8.1% (6.5% from GU to GU; 0.8% from GU to carcinoma). Possible reasons for the recurrence were explored: technical errors in 79% DU and 90% GU (inadequate vagotomy, motility disturbances). No cause could be found in 18% DU and 10% GU. An increase in recurrences is caused by a deterioration in the clinical picture in the last two decades.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 39 (1974), S. 1600-1603 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 39 (1974), S. 1597-1600 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 38 (1973), S. 2725-2727 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 47 (1982), S. 287-292 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Industrial relations journal 26 (1995), S. 0 
    ISSN: 1468-2338
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: The employment system of the former GDR–like that of other socialist countries–could be seen as an aggregation of ‘internal labour markets’ with long term employment, internal promotion and little external mobility. Consequently the rapid integration of the East German economy into the western market economy has led to structural problems of the labour market which combined with and intensified the general effects of the sharp decrease in the demand for labour.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 25 (1998), S. 0 
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. The aim of the present study was to compare the effects of guided tissue regeneration (GTR) with non-resorbable (ePTFE) and biodegradable barriers (Polyglactin 910). 23 patients provided 29 pairs of similar contralateral periodontal defects (12 pairs of interproximal intrabony lesions. 11 pairs of degree II and 6 pairs of degree III furcation defects). Each defect was randomly assigned to treatment with either non-resorbable (control [c]) or biodegradable (test [t]) devices. At baseline, 6, 12, 18, and 24 months after surgery, clinical measurements (P1I, GI, PPD, PAL-V, PAL-H) were performed. Standardized radiographs were obtained at baseline 12 and 24 months postsurgically. On the radiographs, the linear distances from the cemento-enamel junction (CEJ) to the alveolar crest (AC) and from the CEJ to bottom of the bony defect (BD) were measured using a computer-assisted analysing method (LMSRT). Both treatments revealed a significant (p 〈 0.05) PPD reduction [all defects: −2.97±1.90 mm (t). –2.21±1.73 mm (c); intrabony defects: –4.00±1.96 mm (t), –3.00 ± 1.87 mm (c); degree II furcations: –2.67 ± 0.97 mm (t), –2.08 ± 1.54 mm (c)], PAL-V gain [all defects: 2.02 ± 1.83 mm (t), 1.18 mm ± 1.50 (c): intrabony defects: 3.45 ± 1.48 mm (t), 1.95 ± 1.64 mm (c); degree II furcations: 1.33 ± 0.94 mm (t), 0.92 ± 1.47 mm (c)], PAL-H gain [degree II furcations: 2.22 ± 0.94 mm (t), 1.86 ± 0.60 mm (c)], and radiographic changes [CEJ-AC: −0.56 ± 1.98 mm (t), −0.06 ± 1.19 mm (c); CEJBD: 2.10 ± 1.92 mm (t), 1.24 ± 2.04 mm (c)] after 24 months. For degree III furcations, neither statistically significant PPD reduction nor PAL-V gain was observed. Similar clinical and radiographic results were found 12 and 24 months after surgical treatment using either non-resorbable or biodegradable barriers. More favorable results concerning PAL-V gain in interproximal intrabony defects could be observed with biodegradable barriers after 24 months than using nonresorbable membranes. Whereas interproximal intrabony lesions and degree 11 furcation defects responded favorably to GTR therapy, through-and-through furcations must be looked upon as a contraindication for this regenerative technique. Based on the results of the present study, the use of biodegradable barriers in GTR may be recommended and, thereby, a surgical re-entry to remove nonresorbable barriers can be avoided.
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