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Distinct TCR δ repertoires are present in the cutaneous lesions and inflamed duodenum of patients with dermatitis herpetiformis (2002)

Holtmeier, Wolfgang ; Pfänder, Michael ; Zollner, Thomas M. ; [et al.]

Oxford, UK : Munksgaard International Publishers

Experimental dermatology 11 (2002), S. 0

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ISSN: 1600-0625

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract: Intraepithelial γδ T cells are increased in the inflamed small bowel and are also found in increased numbers in cutaneous lesions from patients with dermatitis herpetiformis (DH). Thus, these cells might play an important role in the pathogenesis of the disease. We investigated the T-cell receptor (TCR) δ repertoire in involved and non-involved skin and compared it with the TCR δ repertoire of the inflamed duodenum and peripheral blood of the same patients. An identical TCR δ repertoire in the small bowel and in the cutaneous lesions would suggest a migration of antigen-specific γδ T cells from the intestine to the skin which cross-react with cutaneous antigens. T-cell receptor DV1-DV3 transcripts were amplified by reverse transcriptase (RT)-PCR and analyzed by complementarity determining region 3 (CDR3) size spectratyping and nucleotide sequencing. Our results indicate that the cutaneous TCR δ repertoires were oligoclonal and identical dominant γδ T-cell clones were present in the involved and non-involved skin. Furthermore, the TCR δ repertoire of the skin was distinct from that in the small bowel. The peripheral blood exhibited a restricted TCR δ repertoire, which differed from that in the intestine and skin. Thus, cutaneous γδ T cells are not specifically expanded within the involved skin and are unlikely to be derived from the inflamed duodenum.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1034/j.1600-0625.2002.110605.x

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Anti-Markownikow-Addition bei der Oxymercurierung von 19-Hydroxy-5-cholesten-3β-ylacetat (1978)

Welzel, Peter ; Holtmeier, Wolfgang ; Weßling, Bernhard

Weinheim : Wiley-Blackwell

Liebigs Annalen 1978 (1978), S. 1327-1332

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ISSN: 0075-4617

Keywords: Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Description / Table of Contents: Anti-Markovnikov Addition in the Oxymercuration of 19-Hydroxy-5-cholesten-3β-yl AcetateOxymercuration of 19-hydroxy-5-cholesten-3β-yl acetate (1a) gives the anti-Markovnikov product 2. Reduction of 2 with sodium tetrahydroborate yields the C-5-epimers 3b and 6b.

Notes: 19-Hydroxy-5-cholesten-3β-ylacetat (1a) reagiert mit Quecksilber(II)-trifluoracetat zum Anti-Markownikow-Produkt 2. Reduktion von 2 mit Natriumtetrahydroborat führt zu den 5-Epimeren 3b und 6b.