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  • 1
    Electronic Resource
    Electronic Resource
    Frequency distribution of plasma cells in the medullary cords of tumour-draining axillary and paracolic lymph nodes (1987)
    Springer
    Virchows Archiv 411 (1987), S. 239-243 
    Details
    ISSN: 1432-2307
    Keywords: Plasma cells ; Axillary lymph nodes ; Paracolic lymph nodes ; Medullary cords ; Breast cancer ; Adenocarcinoma of the large bowel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five hundred and ninety-seven axillary lymph nodes draining 104 invasive ductal breast cancers, and 94 paracolic lymph nodes draining 30 invasive adenocarcinomas of the large bowel were investigated immunohistologically to determine the frequency distribution of plasma cells (PC) in the medullary cords (MC). The degree of plasmacytic infiltration was calculated semiquantitatively using the 3-grade scale (0/+, ++, +++) of Cottier et al. (1973). Statistical analysis yielded the following results: While a marked reactive plasmacytosis (+++) was seen in 28.7% of the paracolic lymph nodes, only 1.5% of the axillary lymph nodes exhibited a comparable degree of plasmacytic infiltration (p〈0.0001). Conversely, low PC counts (0/+) were encountered in 51.1% of the paracolic lymph nodes, but in 83.9% of the axillary lymph nodes. A comparison of axillary lymph nodes with and without nodal metastastation revealed significant differences (nodal-negative cases: 0/+: 83.6%, ++: 14.3%, +++: 2.1%; nodal-positive cases: 0/+: 84.3%, ++: 14.9%, +++: 0.8%). However, significantly more (p〈0.001) paracolic lymph nodes of the nodal-negative group revealed a marked plasmacytosis, whereas in the nodal-positive group lymph nodes with low PC counts were more frequent (nodal-negative cases: 0/+: 27.7%, ++: 29.7%, +++: 42.6% ; nodal-positive cases: 0/+: 74.5%, ++: 10.6%, +++: 14.9%). The degree of plasmacytic reactions in the tumour-regional lymph nodes was not related to the stage of the primary tumour. Moreover, no correlation exists between the PC content of the MC and the amount of PC in metastatic deposits of the same lymph nodes. Altogether, these results do not support the concept that the plasmacytic reactions in the MC of tumour-draining lymph nodes are chiefly determined by effects (stimulating or suppressing) of the primary carcinomas. The topography of the lymph nodes, however, seems to be the main determinant influencing the PC content of MC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735029
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  • 2
    Electronic Resource
    Electronic Resource
    Solitary mastocytoma of the eyelid (1987)
    Springer
    Virchows Archiv 412 (1987), S. 31-36 
    Details
    ISSN: 1432-2307
    Keywords: Eyelid tumour ; Immunocytology ; Mastocytoma ; Tissue mast cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Solitary mastocytoma (mast cell naevus) of the skin represents a relatively rare dermal tumour. Its occurrence on the lower eyelid is exceptional. We report the case of a 4 month old male infant who exhibited a firm, yellowish nodule (1 cm in maximum diameter) on the lower lid of the right eye from birth. Histologically, the tumour consisted of strongly metachromatic tissue mast cells (TMC) infiltrating the whole dermis, the adjacent subcutaneous tissue and the lid muscle. Since comparable skin lesions in other sites were not observed, a diagnosis of solitary mastocytoma was made. Immunocytological investigations revealed strong reactivity of the TMC to antisera against vimentin, common leucocyte antigen (CLA),α1-antitrypsin (α1-AT) and α1-antichymotrypsin (α1-ACT). A minor proportion of the TMC reacted to antisera against lysozyme and KiB3. Surprisingly, the TMC also reacted to antisera against certain regulatory peptides (RP), namely adrenocorticotropic hormone (ACTH), peptide histidine isoleucine (PHI), leu-enkephalin and met-enkephalin. However, absorption controls revealed that the immunostaining for ACTH and the two enkephalins was non-specific. The immunocytological phenotype of TMC suggests a close relationship to the myeloid-monocytic lineage, but a possible relationship between TMC and the diffuse neuroendocrine system needs further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00750728
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  • 3
    Electronic Resource
    Electronic Resource
    Das desmoplastische Plattenepithelkarzinom der Haut und Unterlippe Eine morphologische Entität mit hohem Metastasierungs- und Rezidivierungsrisiko (1998)
    Springer
    Der Hautarzt 49 (1998), S. 104-108 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Plattenepithelkarzinom der Haut und Unterlippe ; desmoplastischer Typ ; Perineurale infiltration ; Neurotopes Plattenepithelkarzinom ; Histopathologie ; Histologische Schnittrandkontrolle ; Malignität ; Key words Squamous cell carcinoma of the skin and vermilion border ; Desmoplastic type ; perineural invasion ; Neurotropic ; Fine stranded squamous cell carcinoma ; Histopathology ; Micrographic surgery ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The desmoplastic type of the squamous cell carcinoma (DSCC) of the skin is an entity which is readily distinguished by light microscopy. The DSCC has fine branches surrounded by a desmoplastic stroma and shows in some cases typical perineural, perivascular and widespread intradermal invasion (maximum 6 cm!). This type accounts for 8.2% (n=44) of our collective of 594 squamous cell carcinomas (SCC) of the skin and vermilion border. Clinically DSCC look like other malignant epithelial tumors of the skin. All tumors were followed up for at least 3 years (maximum 10 years). The local recurrence rate was high (24.3%) even though micrographic surgery was carried out. The rate of local or regional metastasis was also very high (22.7%). In comparison the recurrence rate and the rate of metatasis of the remaining common 91.8% SCC’s (n=550) was low: 2.6% and 3.8%, respectively. The DSCC seems to be identical with the so called neurotropic SCC, the fine stranded SCC or the SCC with perineural invasion which have a high rate of local recurrence and metastasis as well, but DSCC is a better generic histopathologic term for the entire group. The DSCC is best treated with micrographic surgery and wider safety margins than any other type and should be followed up very frequently.
    Notes: Zusammenfassung Der desmoplastische Typ des Plattenepithelkarzinoms der Haut (DPEK) wurde bisher in der Literatur einmal erwähnt. Der Tumor zeigt in schmalen Strängen wachsende atypische Plattenepithelien, z.T. mit Verhornungszeichen und einer auffallenden desmoplastischen Stromareaktion. In unserem Kollektiv der Plattenepithelkarzinome (PEK) der Haut und Unterlippe (n=594) ist das DPEK mit 8,2% vertreten. Klinisch läßt er sich von anderen epithelialen Tumoren nicht unterscheiden. Bei einer Nachbeobachtungszeit von minimal 3 und maximal 10 Jahren fanden wir sowohl eine hohe Lokalrezidivierungsrate (24,3%) trotz durchgeführter lückenloser histologischer Schnittrandkontrolle im Paraffinschnittverfahren als auch eine sehr hohe lokoregionäre Metastasierung (22,7%). Fälle mit perineuraler bzw. auch perivaskulärer und ausgedehnter intradermaler (Maximum 6 cm!) Infiltration kommen vor. Der gewöhnliche Typ des PEK unseres untersuchten Kollektives (91,8%) zeigt dagegen sowohl eine niedrige Lokalrezidivierungsrate (2,6%) als auch eine niedrige Metastasierungsrate (3,8%). Das DPEK scheint identisch zu sein mit dem sog. neurotopen, bzw. dem perineural infiltrierenden und dem feinstrangigen („fine stranded”) Typ des PEK, welche ebenfalls eine hohe Lokalrezidiv- und Metastsierungsrate aufweisen. Die Bezeichnung desmoplastisches Plattenepithelkarzinom stellt den histopathologisch besser definierten Oberbegriff dar. Das DPEK benötigt eine deutlich radikalere lokale Therapie sowie eine engmaschigere Nachkontrolle als die gewöhnlichen Typen des PEK der Haut.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050708
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  • 4
    Electronic Resource
    Electronic Resource
    Lectin-binding studies of a human skin mastocytoma (1989)
    Springer
    Journal of molecular histology 21 (1989), S. 44-46 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A solitary mastocytoma of the skin was investigated to assess the lectin-binding pattern of human mast cells. Of 18 Fluorescein-labelled lectins tested, nine reacted with mast cell granules. While lectins recognizingN-acetylgalactosamine or fucose residues did not stain mast cells, lectins with binding sites forN-acetylglucosamine, α-methyl mannopyranoside, galactose, complex carbohydrates ofN-acetyl-lactosamine type and sialic acid gave a positive reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01002470
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  • 5
    Electronic Resource
    Electronic Resource
    Lectin histochemistry of human bone marrow: investigation of trephine biopsy specimens in normal and reactive states and neoplastic disorders (1991)
    Springer
    Journal of molecular histology 23 (1991), S. 215-220 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The lectin binding pattern of bone marrow cells in normal and reactive states and in various neoplastic disorders was investigated using trephine biopsy specimens taken from the iliac crest. The tissue samples were routinely processed (fixed in formalin and embedded in paraffin wax) and subjected to mild decalcification with EDTA. The following results were obtained. (1) More than half of the 23 fluoresceinated lectins used reacted with normal blood cells and/or their neoplastic derivatives. Inhibition tests with the appropriate sugars confirmed the specificity of binding for the majority, but not all, of the lectins. (2) WGA, Con A, PSA, STA and RCA60 and RCA120 produced a particularly intense reaction with normal, reactive and neoplastic myeloid cells. Erythroblasts exhibited weak staining in a few cases by a few lectins (WGA producing the strongest staining), while megakaryocytes nearly always remained unstained. Neoplastic lymphoid cells in various lymphoproliferative disorders and plasmacytoma cells generally reacted with the same lectins as the myeloid cells. (3) Since neoplastic myeloid cells in various myelodysplastic and myeloproliferative disorders exhibited a lectin binding pattern similar to that of myeloid cells in normal and reactive bone marrow, it is unlikely that lectin histochemistry of the bone marrow will prove of great value in the diagnosis of myelodysplastic—myeloproliferative disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01462243
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