ISSN:
1432-1041
Keywords:
amitriptyline
;
kidney function
;
uraemics
;
biotransformation
;
chronic renal failure
;
urinary metabolites
;
man
;
depression
;
nortryptyline
;
hydroxymetabolites
;
unconjugated metabolites
;
clinical efficacy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The metabolism of amitriptyline (AMT) has been studied in two groups of depressed in-patients on long term AMT therapy: 11 patients with no other major disease and 8 patients with chronic renal failure, who were being dialysed. The patients with renal insufficiency had decreased concentrations of AMT, nortriptyline (NT) and their unconjugated hydroxymetabolites compared to patients with normal kidney function. The plasma levels of conjugated products were extremely high in the uraemics. The latter metabolites are probably inert. The reduced concentration of unconjugated hydroxymetabolites, which are active compounds, may decrease the clinical effectiveness of the drug.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00630290
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